JIALIN WU^1,2,#, ZEHONG CHEN³, WENWEI LIU^1,#, YONGXIN ZHANG¹, WEI FENG¹, YUJIE YUAN¹, JINNING YE¹, LIANG WANG¹, SHIRONG CAI¹, YULONG HE¹, SUIJING WU^4,*, WU SONG^1,*

Oncology Research, Vol.29, No.2, pp. 119-128, 2021, DOI:10.32604/or.2022.03178

Abstract Objective: MicroRNA-188-5p (miR-188) enhances oncologic progression in various human malignancies. This study aimed to explore its role in colorectal cancer (CRC). Materials and Methods: Human CRC tissues paired with normal tissues, and several CRC cell lines were utilized. Real-time quantitative PCR was applied to measure the expression of miR-188. Overexpression and knockdown were used to access the function of miR-188 and to investigate whether FOXL1/Wnt signaling mediates such function. The proliferation, migration and invasion of cancer cells were evaluated by CCK8, wound-healing and transwell assays, respectively. Whether FOXL1 acted as a direct target of miR-188 was verified by dual-luciferase reporter… More >

Meng Wang^*1, Xin Wang^†1, Yuan Li^‡1, Qiang Xiao^§, Xiao-Hai Cui^*, Guo-Dong Xiao^*, Ji-Chang Wang^¶, Chong-Wen Xu^#, Hong Ren^*, Dapeng Liu^*

Oncology Research, Vol.27, No.9, pp. 987-995, 2019, DOI:10.3727/096504018X15424918479652

Abstract The aim of this study was to investigate the potential biological activities of nutlin-3 in the regulation of growth and proliferation of non-small cell lung cancer (NSCLC) stem cells (CSCs), which may help in sensitizing to axitinib-induced apoptosis. Nutlin-3 induction of p53 expression was used to test its role in controlling the cell division pattern and apoptosis of NSCLC cells. A549 cells and H460 cells were pretreated with nutlin-3 and then treated with either an Akt1 activator or shRNA-GSK3 , to investigate the potential role of p53 sensitization in the biological effects of axitinib. We also determined the expression levels… More >

TING LI^1,#, XINHUI SUN^2,#, NANNAN LI¹, HONGMIN GUO^2,*

BIOCELL, Vol.45, No.4, pp. 985-994, 2021, DOI:10.32604/biocell.2021.012371

Abstract Fibroblast growth factors (FGFs) play pivotal roles in cell migration and proliferation. However, the identity of the FGF that plays a dominant role in kidney cell proliferation remains unclear. Therefore, in this study, we investigated the dominant FGF among all FGFs. To this end, RNA-sequencing, qRT-PCR, western blotting, and ChIP assays were performed. FGF9 showed the highest expression among all FGFs, and its overexpression significantly promoted proliferation in the mouse kidney cell line C57BL/6 and increased JNK and AKT phosphorylation levels. Further, RNA-seq analysis identified 365 upregulated and 276 downregulated genes in FGF9-overexpressed cells. These differentially expressed genes were classified… More >

J. B. Kim¹, P. Leucht^1,2, K. Lam¹, C. A. Luppen¹, D. ten Berg³, R. Nusse³, J. A. Helms¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 201-201, 2006, DOI:10.32604/mcb.2006.003.201

Abstract This article has no abstract. More >