UMAPATHY PRAKASH1, SUBRAMANIAM RAJESH BHARATHIDEVI1,*, RAMYA R. NADIG2, RAJIV RAMAN2, GIRISH SHIV RAO2, MUNA BHENDE2
BIOCELL, Vol.47, No.7, pp. 1473-1482, 2023, DOI:10.32604/biocell.2023.027804
Abstract Zinc alpha 2 glycoprotein (ZAG) is a 41 KDa secretory soluble glycoprotein found in different body fluids like
the serum, saliva, sweat, breast milk, and urine. It is also found in tissues like the testis, epididymis, kidney, spleen, liver,
lungs, heart, and brain. ZAG is an adipokine with multiple roles, including lipid mobilization, modulating glucose
metabolisms, improving insulin sensitivity, inhibiting tumor proliferation through RNAse activity, and suppressing
inflammation. Low levels of zinc and ZAG are linked to metabolic syndrome and are also reported as potential
biomarkers for diabetic nephropathy. Interestingly zinc has been found to regulate the binding of ZAG… More >
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