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    Endothelial Tight Junction Protein ZO-1 Response to Multiple-Mechanical Stimulations After Stent Implamtation

    Yang Wang1, Shuang Ge1, Junyang Huang1, Ruolin Du1, Tieying Yin1, Guixue Wang1,*, Yazhou Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 140-141, 2019, DOI:10.32604/mcb.2019.07300

    Abstract Zonula occludens-1 (ZO-1) is a peripheral membrane protein belongs to the family of zona occludens proteins and plays an important role as a scaffold protein which cross-links and anchors tight junction (TJ) strand proteins, within the lipid bilayer, to the actin cytoskeleton[1-2]. Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy junctions of endothelial cells, the functions of the tight junction were also affected. However, the role of ZO-1 before and after stent implantation has not been fully understood. In this study, the expression of ZO-1 were analyzed by qPCR, western blot and… More >

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