Matthew Lewis¹, William Whang², Angelo Biviano², Kathleen Hickey², Hasan Garan², Marlon Rosenbaum¹

Congenital Heart Disease, Vol.14, No.2, pp. 207-212, 2019, DOI:10.1111/chd.12695

Abstract Background: Catheter ablation is commonly performed to treat atrial arrhythmias in adult congenital heart disease (ACHD). Despite the frequency of ablations in the ACHD population, predictors of recurrence remain poorly defined.
Objective: We sought to determine predictors of arrhythmia recurrence in ACHD patients following catheter ablation for atrial arrhythmias.
Methods: We performed a retrospective study of all catheter ablations for atrial arrhythmias performed in ACHD patients between January 12, 2005 and February 11, 2015 at our institution. Prespecified exposures of interest and time from ablation to recurrence were determined via chart review.
Results: Among 124 patients (mean age: 45 years)… More >

Nan Shen^1,2, Dabajyoti Datta¹, Chris B. Schaffer^1,3,4,5, Eric Mazur^1,6

Molecular & Cellular Biomechanics, Vol.2, No.1, pp. 17-26, 2005, DOI:10.3970/mcb.2005.002.017

Abstract Analysis of cell regulation requires methods for perturbing molecular processes within living cells with spatial discrimination on the nanometer-scale. We present a technique for ablating molecular structures in living cells using low-repetition rate, low-energy femtosecond laser pulses. By tightly focusing these pulses beneath the cell membrane, we ablate cellular material inside the cell through nonlinear processes. We selectively removed sub-micrometer regions of the cytoskeleton and individual mitochondria without altering neighboring structures or compromising cell viability. This nanoscissor technique enables non-invasive manipulation of the structural machinery of living cells with several-hundred-nanometer resolution. Using this approach, we unequivocally demonstrate that mitochondria are… More >

T.I. Zohdi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.3, pp. 261-277, 2014, DOI:10.32604/cmes.2014.098.261

Abstract A widespread use of lasers is for the ablation of biological tissue, in particular for dermal applications involving the removal of cancerous tissue, skin spots, aged skin and wrinkles. For a laser to ablate tissue, the power intensity must be sufficiently high to induce vaporization/burning of the target material. However, if performed improperly, the process can cause excessive microscale thermal injuries to surrounding healthy tissue. This motivates the present work, which attempts to develop and assemble simple models for the primary heat transfer mechanisms that occur during the process. First, in order to qualitatively understand the system, the terms that… More >

Leonid V. Zhigilei¹, Avinash M. Dongare¹

CMES-Computer Modeling in Engineering & Sciences, Vol.3, No.5, pp. 539-556, 2002, DOI:10.3970/cmes.2002.003.539

Abstract Computational modeling has a potential of making an important contribution to the advancement of laser-driven methods in nanotechnology. In this paper we discuss two computational schemes developed for simulation of laser coupling to organic materials and metals and present a multiscale model for laser ablation and cluster deposition of nanostructured materials. In the multiscale model the initial stage of laser ablation is reproduced by the classical molecular dynamics (MD) method. For organic materials, the breathing sphere model is used to simulate the primary laser excitations and the vibrational relaxation of excited molecules. For metals, the two temperature model coupled to… More >