Osama M. Alshehri¹, Ahmad Shaf^2,*, Muhammad Irfan^3,*, Mohammed M. Jalal⁴, Malik A. Altayar⁴, Mohammed H. Abu-Alghayth⁵, Humood Al Shmrany⁶, Tariq Ali⁷, Toufique A. Soomro⁸, Ali G. Alkhathami⁹

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 1165-1196, 2025, DOI:10.32604/cmes.2025.067150 - 31 July 2025

Abstract Background: Accurate classification of normal blood cells is a critical foundation for automated hematological analysis, including the detection of pathological conditions like leukemia. While convolutional neural networks (CNNs) excel in local feature extraction, their ability to capture global contextual relationships in complex cellular morphologies is limited. This study introduces a hybrid CNN-Transformer framework to enhance normal blood cell classification, laying the groundwork for future leukemia diagnostics. Methods: The proposed architecture integrates pre-trained CNNs (ResNet50, EfficientNetB3, InceptionV3, CustomCNN) with Vision Transformer (ViT) layers to combine local and global feature modeling. Four hybrid models were evaluated on… More >

Abdel Nasser H. Zaied¹, Ehab Rushdy², Mona Gamal^3,*

Computer Systems Science and Engineering, Vol.47, No.2, pp. 1349-1364, 2023, DOI:10.32604/csse.2023.033596 - 28 July 2023

Abstract Acute leukemia is an aggressive disease that has high mortality rates worldwide. The error rate can be as high as 40% when classifying acute leukemia into its subtypes. So, there is an urgent need to support hematologists during the classification process. More than two decades ago, researchers used microarray gene expression data to classify cancer and adopted acute leukemia as a test case. The high classification accuracy they achieved confirmed that it is possible to classify cancer subtypes using microarray gene expression data. Ensemble machine learning is an effective method that combines individual classifiers to… More >

Khadija Khan, Samabia Tehsin^*

Journal on Artificial Intelligence, Vol.4, No.1, pp. 1-13, 2022, DOI:10.32604/jai.2022.028092 - 16 May 2022

Abstract Leukemia is the cancer that starts in the blood cells due to the excess production of immature leucocytes that replace the cells with normal blood cells. Physicians rely on their experience to determine the type and subtype of Leukemia from the blood sample. Most people are misdiagnosed when it comes to its subtypes, the error rates can be up to 40% during the classification process. That too depends on the expertise of the physician. This research represents a Convolutional Neural Network based medical image classifier. The proposed technique can classify Leukemia and its five subtypes. More >