Lisa J. Frey^1,*, Nina Lache¹, Nikita D. Fischer¹, Niklas Rölz¹, Lisa Frey¹, Maximilian Haack¹, Gregor Duwe¹, Stefan Porubsky², Axel Haferkamp¹, Daniel-C. Wagner^2,3, Maximilian P. Brandt¹

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.078954 - 16 July 2026

Abstract Objectives: Squamous cell carcinoma (SCC) of the bladder is an aggressive histologic subtype with distinct clinical behavior and limited treatment options after platinum-based chemotherapy. This study aimed to evaluate potential therapeutic targets in bladder SCC. Methods: A retrospective cohort of 790 patients who underwent radical cystectomy for bladder cancer between 2011 and 2021 was screened to identify cases with histologically confirmed SCC. All SCC cases in the pathology department from 2003 to 2011 were also reviewed. Clinical and pathological data from 54 patients were analyzed. A tissue microarray (TMA) was constructed, and immunohistochemical (IHC) analyses… More >

Bungo Ochiai^*, Yuji Kamachi, Yoshimasa Matsumura^#

Journal of Polymer Materials, Vol.43, No.2, 2026, DOI:10.32604/jpm.2026.078288 - 30 June 2026

Abstract Epoxy-acrylate hybrid systems are extensively employed in adhesives, coatings, and composites; however, conventional formulations often rely on toxic monomers such as glycidyl methacrylate (GMA). This study introduces a sequentially curable epoxy-acrylate hybrid system based on novel hybrid monomers containing both glycidate and acrylate groups, synthesized via the partial oxidation of a diacrylate. Radical polymerization of monomers with a glycidate content exceeding 80% yielded viscous prepolymers consisting of epoxy-functionalized polymers and residual low-molecular-weight glycidates. These prepolymers were subsequently cured with amines at ambient temperature to form crosslinked networks. The gel fraction exceeded 90% when cured with More > Graphic Abstract

Yin-Lun Chang^1,2, Hao-Lun Luo¹, Jei-Ming Peng^3,*, Chang-Chun Hsiao^2,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.070837 - 23 March 2026

Abstract Background: Upper tract urothelial carcinoma (UTUC) is an aggressive malignancy with high recurrence rates. Lymphovascular invasion (LVI) predicts a poor prognosis, yet its molecular drivers remain unclear. BOC cell adhesion-associated, oncogene-regulated (BOC, also known as Brother of CDO [Cell adhesion molecule-Related/Down-regulated by Oncogenes]), a hedgehog-related cell surface receptor, may serve as a biomarker for tumor progression and chemotherapy response. The study aimed to investigate the role of BOC in UTUC and its potential to predict LVI and chemotherapy response. Methods: Sequencing (RNA-seq) of 10 stage III UTUC, treatment-naïve, fresh tissue samples identified BOC as a… More >

Xiaoyu Zhang^1,#, RenFei Zong^1,#, Yan Sun¹, Nan Chen², Kunyao Zhu¹, Hang Tong¹, Tinghao Li¹, Junlong Zhu¹, Zijia Qin¹, Linfeng Wu¹, Aimin Wang¹, Weiyang He^1,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.072084 - 19 January 2026

Abstract Objective: While cisplatin-based chemotherapy is pivotal for advanced bladder cancer, acquired resistance remains a major obstacle. This study investigates key molecular drivers of this resistance and potential reversal strategies. Methods: We established GC (Gemcitabine and Cisplatin)-resistant T24-R and UC3-R cell lines from T24 and UM-UC-3 (UC3) cells. Transcriptomic and proteomic analyses identified differentially expressed molecules. Apoptosis and cell viability were assessed by flow cytometry and CCK-8 (Cell Counting Kit-8) assays, while RT-qPCR (Reverse Transcription Quantitative Polymerase Chain Reaction) and Western blot analyzed gene and protein expression. Immunofluorescence evaluated FAK (Focal Adhesion Kinase) phosphorylation, and a… More >

Nanpu Cao¹, Huan Luo¹, Song Yue¹, Yong Chen¹, Mao Xu¹, Pu Cao¹, Tao Xin¹, Hongying Luo¹, Fa Zhang^2,*

Journal of Polymer Materials, Vol.42, No.3, pp. 661-675, 2025, DOI:10.32604/jpm.2025.067313 - 30 September 2025

Abstract This review systematically summarizes recent advancements in the design of antibacterial hydrogels and the surface-related factors influencing microbial adhesion to polymeric materials. Hydrogels, characterized by their three-dimensional porous architecture and ultra-high water content, serve as ideal platforms for incorporating antibacterial agents (e.g., metal ions, natural polymers) through physical/chemical interactions, enabling sustained release and enhanced antibacterial efficacy. For traditional polymers, surface properties (e.g., roughness, charge, superhydrophobicity, free energy, nanoforce gradients) play critical roles in microbial adhesion. Modifying the surface properties of polymers through surface treatment can regulate antibacterial performance. In particular, by referencing the micro/nanostructures found More >

Yi Zhang¹, Wenliang Zhu^1,*, Hanbin Wang¹, Chun Tian², Jiajun Zhou²

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 2873-2891, 2025, DOI:10.32604/cmes.2025.068951 - 30 September 2025

Abstract Aiming to address the challenge of directly measuring the real-time adhesion coefficient between wheels and rails, this paper proposes an online estimation algorithm for the adhesion coefficient based on parameter estimation. Firstly, a force analysis of the single-wheel pair model of the train is conducted to derive the calculation relationship for the wheel-rail adhesion coefficient in train dynamics. Then, an estimator based on parameter estimation is designed, and its stability is verified. This estimator is combined with the wheelset force analysis to estimate the wheel-rail adhesion coefficient. Finally, the approach is validated through joint simulations… More >

Ksenia Saerova^*, Ruslan Safin

Journal of Renewable Materials, Vol.13, No.9, pp. 1829-1840, 2025, DOI:10.32604/jrm.2025.02025-0076 - 22 September 2025

Abstract This article presents research focused on developing and scientifically substantiating a technology for producing environmentally friendly glued structures from wood treated through a two-stage process. The methodology involves preliminary thermal modification followed by high-frequency low-temperature plasma treatment. Thermal modification enhances performance characteristics such as resistance to rot, lowers hygroscopicity, and increases dimensional stability. However, it can diminish the adhesive properties of wood, complicating the bonding process. To address this challenge, the study introduces high-frequency low-temperature plasma treatment, which activates the wood surface, improving wettability and adhesion while minimizing glue consumption. Experimental results indicate that plasma More >

WENZHUO YANG^1,#, HAODONG CHEN^2,#, ZHILAN ZHANG³, ZHIYONG XIA³, YUANYUAN JIN^1,*, ZHAOYONG YANG^1,*

Oncology Research, Vol.33, No.6, pp. 1485-1494, 2025, DOI:10.32604/or.2025.059426 - 29 May 2025

Abstract Background: Human natural killer (NK) cells have attracted widespread attention as a potential adoptive cell therapy (ACT). However, the therapeutic effects of NK cell infusion in patients with solid tumors are limited. There is an urgent need to explore a suitable new treatment plan to overcome weaknesses and support the superior therapeutic activity of NK cells. Methods: In this study, the mechanisms underlying the susceptibility of gastric cancer (GC) cell lines AGS, HGC-27, and NCI-N87 to NK cell-mediated cytotoxicity were explored. Results: Lactic dehydrogenase (LDH) release assays showed that all three GC cell lines were susceptible… More >

Changhong Linghu^1,*, Huajian Gao^1,2, K. Jimmy Hsia^1,3

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.2, pp. 1-2, 2024, DOI:10.32604/icces.2024.011590

Abstract Shape memory polymers (SMPs), with unique properties such as tunable elastic modulus, temporary shape-locking, and shape-recovery upon external stimulations, are emerging as a new class of smart materials with switchable adhesion capabilities. A prominent feature of the adhesion between SMP and a spherical indenter is the so-called R2G adhesion, defined as making contact in the rubbery state to a certain indentation depth followed by detachment in the glassy state. While it has been demonstrated that the R2G adhesion with SMPs can achieve orders of magnitude higher adhesive strength compared to conventional elastic adhesive systems, the… More >

Bahareh Tajvidi Safa¹, Jordan Rosenbohm¹, Ruiguo Yang^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.011477

Abstract Cell-cell adhesions are often subjected to mechanical strains of different rates and magnitudes in normal tissue function and in disease conditions. To date, few strategies exist to directly and quantitatively investigate the effect of mechanical forces exerted by cell-cell adhesions, even less the effect of applied load on the transduction of these forces into biochemical signals. To address this knowledge gap, we designed and fabricated a platform that performs quantitative mechanical characterization of single cell-cell adhesion structures using two photon polymerization of multiple materials [1]. This microsystem provides interrogation and stimulation of cell-cell junctions through… More >