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  • Open Access

    REVIEW

    Design of Nanostructured Surfaces and Hydrogel Coatings for Anti-Bacterial Adhesion

    Nanpu Cao1, Huan Luo1, Song Yue1, Yong Chen1, Mao Xu1, Pu Cao1, Tao Xin1, Hongying Luo1, Fa Zhang2,*

    Journal of Polymer Materials, Vol.42, No.3, pp. 661-675, 2025, DOI:10.32604/jpm.2025.067313 - 30 September 2025

    Abstract This review systematically summarizes recent advancements in the design of antibacterial hydrogels and the surface-related factors influencing microbial adhesion to polymeric materials. Hydrogels, characterized by their three-dimensional porous architecture and ultra-high water content, serve as ideal platforms for incorporating antibacterial agents (e.g., metal ions, natural polymers) through physical/chemical interactions, enabling sustained release and enhanced antibacterial efficacy. For traditional polymers, surface properties (e.g., roughness, charge, superhydrophobicity, free energy, nanoforce gradients) play critical roles in microbial adhesion. Modifying the surface properties of polymers through surface treatment can regulate antibacterial performance. In particular, by referencing the micro/nanostructures found More >

  • Open Access

    ARTICLE

    Online Estimation Method of Train Wheel-Rail Adhesion Coefficient Based on Parameter Estimation

    Yi Zhang1, Wenliang Zhu1,*, Hanbin Wang1, Chun Tian2, Jiajun Zhou2

    CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 2873-2891, 2025, DOI:10.32604/cmes.2025.068951 - 30 September 2025

    Abstract Aiming to address the challenge of directly measuring the real-time adhesion coefficient between wheels and rails, this paper proposes an online estimation algorithm for the adhesion coefficient based on parameter estimation. Firstly, a force analysis of the single-wheel pair model of the train is conducted to derive the calculation relationship for the wheel-rail adhesion coefficient in train dynamics. Then, an estimator based on parameter estimation is designed, and its stability is verified. This estimator is combined with the wheelset force analysis to estimate the wheel-rail adhesion coefficient. Finally, the approach is validated through joint simulations… More >

  • Open Access

    ARTICLE

    Improving the Environmental Friendliness of Glued Structures Made of Thermal Wood by Preliminary Low-Temperature Plasma Treatment

    Ksenia Saerova*, Ruslan Safin

    Journal of Renewable Materials, Vol.13, No.9, pp. 1829-1840, 2025, DOI:10.32604/jrm.2025.02025-0076 - 22 September 2025

    Abstract This article presents research focused on developing and scientifically substantiating a technology for producing environmentally friendly glued structures from wood treated through a two-stage process. The methodology involves preliminary thermal modification followed by high-frequency low-temperature plasma treatment. Thermal modification enhances performance characteristics such as resistance to rot, lowers hygroscopicity, and increases dimensional stability. However, it can diminish the adhesive properties of wood, complicating the bonding process. To address this challenge, the study introduces high-frequency low-temperature plasma treatment, which activates the wood surface, improving wettability and adhesion while minimizing glue consumption. Experimental results indicate that plasma More >

  • Open Access

    ARTICLE

    Exploring the correlation and mechanism of natural killer cell cytotoxic sensitivity against gastric cancer

    WENZHUO YANG1,#, HAODONG CHEN2,#, ZHILAN ZHANG3, ZHIYONG XIA3, YUANYUAN JIN1,*, ZHAOYONG YANG1,*

    Oncology Research, Vol.33, No.6, pp. 1485-1494, 2025, DOI:10.32604/or.2025.059426 - 29 May 2025

    Abstract Background: Human natural killer (NK) cells have attracted widespread attention as a potential adoptive cell therapy (ACT). However, the therapeutic effects of NK cell infusion in patients with solid tumors are limited. There is an urgent need to explore a suitable new treatment plan to overcome weaknesses and support the superior therapeutic activity of NK cells. Methods: In this study, the mechanisms underlying the susceptibility of gastric cancer (GC) cell lines AGS, HGC-27, and NCI-N87 to NK cell-mediated cytotoxicity were explored. Results: Lactic dehydrogenase (LDH) release assays showed that all three GC cell lines were susceptible… More >

  • Open Access

    PROCEEDINGS

    Mechanics of Shape-Locking-Governed R2G Adhesion with Shape Memory Polymers

    Changhong Linghu1,*, Huajian Gao1,2, K. Jimmy Hsia1,3

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.2, pp. 1-2, 2024, DOI:10.32604/icces.2024.011590

    Abstract Shape memory polymers (SMPs), with unique properties such as tunable elastic modulus, temporary shape-locking, and shape-recovery upon external stimulations, are emerging as a new class of smart materials with switchable adhesion capabilities. A prominent feature of the adhesion between SMP and a spherical indenter is the so-called R2G adhesion, defined as making contact in the rubbery state to a certain indentation depth followed by detachment in the glassy state. While it has been demonstrated that the R2G adhesion with SMPs can achieve orders of magnitude higher adhesive strength compared to conventional elastic adhesive systems, the… More >

  • Open Access

    PROCEEDINGS

    A Platform to Examine the Mechanics and Mechanotransduction of Single Cell-Cell Adhesions

    Bahareh Tajvidi Safa1, Jordan Rosenbohm1, Ruiguo Yang1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.011477

    Abstract Cell-cell adhesions are often subjected to mechanical strains of different rates and magnitudes in normal tissue function and in disease conditions. To date, few strategies exist to directly and quantitatively investigate the effect of mechanical forces exerted by cell-cell adhesions, even less the effect of applied load on the transduction of these forces into biochemical signals. To address this knowledge gap, we designed and fabricated a platform that performs quantitative mechanical characterization of single cell-cell adhesion structures using two photon polymerization of multiple materials [1]. This microsystem provides interrogation and stimulation of cell-cell junctions through… More >

  • Open Access

    PROCEEDINGS

    Mechanics of Freezing-Empowered Self-Catapulting of Water Droplets

    Haimin Yao1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.012649

    Abstract Despite the remarkable progress of anti-icing and deicing technologies in the past decades, it remains a grand challenge to dislodge freezing water from a solid surface without consuming external energy. Herein, we propose a strategy to dislodge freezing water from solid surfaces just by leveraging its volume expansion resulting from the phase change from water to ice. The implementation of this energy-saving strategy relies on a simple micropillar-based gadget on the surface, termed freezing-empowered droplet catapult (FEDC), whereby the work done by the volume expansion of a freezing droplet accreted on it can be harvested… More >

  • Open Access

    COMMENTARY

    A commentary on the interplay of biomaterials and cell adhesion: new insights in bone tissue regeneration

    A. NOEL GRAVINA1,2, NOELIA D´ELÍA1,2, LUCIANO A. BENEDINI2,3,*, PAULA MESSINA1,2

    BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024

    Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >

  • Open Access

    PROCEEDINGS

    Collision-Induced Adhesion Behavior and Mechanism for Metal Particle and Graphene

    Haitao Hei1, Jian Wang1, Yonggang Zheng1, Hongfei Ye1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011298

    Abstract Micro- and nano-scale collisions are widely involved in molecular movement, drug delivery, the actuation of micro-nano devices, etc. They often exhibit extraordinary behaviour relative to the common macroscopic collisions. A deep understanding on the scale reduction-induced novel collision phenomenon and the related mechanism is rather crucial. In this work, the comprehensive impact behaviour of metal projectiles on graphene is investigated on the basis of molecular dynamics simulations. It is found that besides the common penetration and rebound behaviours, the impacting metal projectile can also be captured by the ultrasoft two-dimensional materials, i.e., the adhesion behaviour.… More >

  • Open Access

    PROCEEDINGS

    A Multiscale Dynamic Model of Cell–Substrate Interfaces

    Huiyan Liang1, Wei Fang1, Xiqiao Feng1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012719

    Abstract Cell–extracellular matrix (ECM) interactions play a pivotal role in many functions of cells, for example, sensing, signaling, migration, and gene expression. The spatial-temporal dynamic evolution of cell–substrate adhesions involves complicated mechano-bio-chemical coupling mechanisms of integrin, adaptor and signaling proteins, and the interplay between the cytoskeleton and ECM as well. In this paper, we establish a multiscale dynamic model of cell–substrate interfaces considering intermolecular force transmission pathways, i.e., intra- and extra-cellular bond dynamics, and mechanochemical coupling regulations. To illustrate its applications, this model is used to reproduce several adhesion-related experimental phenomena of cells, including substrate rigidity… More >

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