Martina Nassif1, Reindert P. van Steenwijk2, Jacqueline M. Hogenhout2, Huangling Lu1, Rianne H.A.C.M. de Bruin‐Bon B Health1, Alexander
Hirsch1,3, Peter J. Sterk MD, PhD2 | Berto J. Bouma MD, PhD1 | Bart Straver
MD, PhD4 | Jan G.P. Tijssen1, Barbara J.M. Mulder1,5, Robbert J. de
Winter1
Congenital Heart Disease, Vol.13, No.6, pp. 959-966, 2018, DOI:10.1111/chd.12665
Abstract Objective: The association between secundum atrial septal defects (ASD) and asthma‐
like dyspnea with consequent long‐term pulmonary inhalant use, is poorly understood
in adult ASD patients. Airway hyperresponsiveness is suggested to be the underlying
mechanism of cardiac asthma from mitral valve disease and ischemic cardiomyopathy.
We hypothesized that airway hyperresponsiveness may also be found in adult ASD
patients. Our aim was to study airway responsiveness in adult ASD patients before
percutaneous closure and at short‐and long‐term postprocedural follow‐up.
Methods: This prospective study included 31 ASD patients (65% female, mean age
49 ± 15y) who underwent spirometry and bronchoprovocation testing pre‐and… More >
Login
Register
