Guangyu Zhu¹, Yuan Wei¹, Qi Yuan^1,*, Ge Yan², Jian Yang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 55-56, 2019, DOI:10.32604/mcb.2019.05730

Abstract This article has no abstract. More >

Stéphane Avril^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 17-18, 2019, DOI:10.32604/mcb.2019.05705

Abstract The fluid mechanics community has been interested for many years in hemodynamics. More recently, significant endeavours of the solid mechanics community have permitted to establish constitutive equations and to achieve stress analyses in arterial lesions (atheromatous plaque in coronary or carotid arteries, aneurysms of the aorta). The mechanical properties of blood vessels have often been characterized ex vivo, but medical imaging, including MRI, now allows non-intrusive identifications in vivo. The spatial heterogeneity of these mechanical properties, even at the macroscopic scale, remains poorly explored despite its undeniable interest in understanding the mechanisms of remodeling and degeneration of… More >

Petit Claudie¹, Guignandon Alain², Avril Stéphane^1,*

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 87-108, 2019, DOI:10.32604/mcb.2019.06415

Abstract The contractile behavior of smooth muscle cells (SMCs) in the aorta is an important determinant of growth, remodeling, and homeostasis. However, quantitative values of SMC basal tone have never been characterized precisely on individual SMCs. Therefore, to address this lack, we developed an in vitro technique based on Traction Force Microscopy (TFM). Aortic SMCs from a human lineage at low passages (4-7) were cultured 2 days in conditions promoting the development of their contractile apparatus and seeded on hydrogels of varying elastic modulus (1, 4, 12 and 25 kPa) with embedded fluorescent microspheres. After complete… More >

Jia-Wang Xiao, Qi-Guang Wang, Duan-Zhen Zhang, Chun-Sheng Cui, Xiumin Han, Po Zhang, Chuangju Hou, Xian-Yang Zhu

Congenital Heart Disease, Vol.13, No.2, pp. 305-310, 2018, DOI:10.1111/chd.12572

Abstract Objective: To evaluate the clinical efficacy, safety, and long-term outcomes of percutaneous closure (PC) and surgical repair of ruptured sinus of Valsalva aneurysm (RSVA).
Methods: Eighty-five consecutive patients with RSVA were included in this study. Patients were considered candidates for PC if they met the criterion, surgical repair was performed on patients who were unsuitable or failed PC. Of them, 30 patients underwent PC, while the other 55 patients had surgical repair.
Results: RSVA was successfully occluded in 29 of 30 patients who were treated by PC. The mean narrowest diameter at the ruptured site was 6.45 ±… More >

Lizhong Mu^{1, *}, Qingzhuo Chi¹, Changjin Ji², Ying He¹, Ge Gao³

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 175-197, 2018, DOI:10.31614/cmes.2018.04191

Abstract To improve aneurysm treatment, this study examined the influence of clip locations on hemodynamic factors in patient-specific anterior communicating artery (ACoA) aneurysms with different aneurysmal angle. We proposed a simplified classification of ACoA aneurysms using aneurysmal angle, defined by the angle of pivot of the aneurysmal dome and the virtual two-dimensional plane created by both proximal A2 segments of anterior cerebral artery (ACA). ACoA aneurysms with three different aneurysmal angles, which are 15°, 80° and 120°, were analyzed in our study. In this work, we obtained hemodynamics before and after clipping surgery with three… More >

LINGFENG CHEN^1,2,3, ZHIPENG GAO^1,2,3, BAIMEI LIU^1,2,3, YING LV^1,2,3, MEIWEN AN^1,2,3,*, JILING FENG^4,*

BIOCELL, Vol.42, No.1, pp. 25-34, 2018, DOI:10.32604/biocell.2018.06114

Abstract Arterial characterization of healthy descending thoracic aorta (DTA) is indispensable in determining stress distributions across wall thickness and different regions that may be responsible for aorta inhomogeneous dilation, rupture, and dissection when aneurysm occurs. Few studies have shown the inhomogeneity of DTA along the aorta tree considering changes in circumferential direction. The present study aims to clarify the circumferential regional characterization of DTA. Porcine DTA tissues were tested according to region and orientation using uniaxial tension. For axial test, results show that the difference in circumferential direction was mainly in collagen fiber modulus, where the… More >

Eric Schommer, Julio Gundian, David D. Thiel

Canadian Journal of Urology, Vol.24, No.2, pp. 8773-8775, 2017

Abstract A65-year-old female presented to clinic requesting follow up for a history of right robotic partial nephrectomy done at an outside institution 2 years prior. Initial pathology demonstrated a grade 2/4 3.4 cm clear cell renal cell carcinoma with negative margins. There was no tumor necrosis, sarcomatoid differentiation, or lymphovascular invasion. High quality follow up imaging initially revealed a pseudoaneurysm in the central portion of the right kidney. The patient was sent to interventional radiology for angioembolization. Angiography identifed the abnormality to be a recurrent or residual mass in the renal hilum. MRI confrmed these fndings, More >

Jane W. Newburger

Congenital Heart Disease, Vol.12, No.5, pp. 633-635, 2017, DOI:10.1111/chd.12498

Abstract Kawasaki disease is an acute febrile arteritis of childhood that can result in coronary artery aneurysms if untreated in the first 10 and ideally 7 days of illness. Kawasaki disease begins as a necrotizing arteritis with neutrophilic infiltrate, followed by subacute/chronic changes and luminal myofibroblastic proliferation that can cause coronary artery stenosis. Manifestations include the presence of ≥5 days of fever, together with clinical criteria of extremity changes, rash, conjunctivitis, oral changes, and unilateral cervical lymphadenopathy. Echocardiography should be performed at the time of diagnosis, then 1–2 weeks and 4–6 weeks later, with more frequent More >

Carolyn A. Altman^1,2

Congenital Heart Disease, Vol.12, No.5, pp. 636-640, 2017, DOI:10.1111/chd.12496

Abstract Echocardiography is an excellent noninvasive imaging modality for evaluation and follow-up of cardiac lesions, especially coronary artery changes occurring as a result of Kawasaki disease. The information obtained has prognostic implications and can be complemented with other modes of imaging for risk stratification and optimization of both medical and interventional therapy. The aim of this article is to describe the time line of echocardiographic follow-up of patients affected with Kawasaki disease. The classification of coronary artery changes and transthoracic echocardiographic views recommended for detailed evaluation of the coronary arteries are delineated in detail in this More >

Zhen Liu¹, Yan Cai¹, Guo-Zhong Chen², Guang-Ming Lu, Zhi-Yong Li^1,3,*

Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 19-31, 2017, DOI:10.3970/mcb.2017.014.019

Abstract Background: Intracranial aneurysm (IA) can be commonly found in the circle of Willis (CoW), and a higher morbidity of IA is found to be associated with a higher percentage of an incomplete CoW. Hemodynamic factors are believed to play an important role in aneurysm formation. However, how the anatomical variations in CoW lead to hemodynamic difference and what hemodynamic parameters play important roles in aneurysm formation have not been quantified and assessed. Methods and Results: Thirty patients were included and based one computed tomography angiography, they were divided into three groups (10 patients per group):… More >