YOHKO YAMAZAKI^1,*, MANABU KAWADA², ISAO MOMOSE¹

Oncology Research, Vol.31, No.6, pp. 845-853, 2023, DOI:10.32604/or.2023.030266

Abstract The androgen receptor (AR) is a critical target in all the clinical stages of prostate cancer. To identify a new AR inhibitor, we constructed a new screening system using the androgen-dependent growth of prostate cancer cell lines as a screening indicator. We screened 50,000 culture broths of microorganisms using this screening system and found that the fermentation broth produced by a fungus inhibited androgen-dependent growth of human prostate cancer LNCaP cells without cytotoxicity. Purification of this culture medium was performed, and this resulted in deoxynortryptoquivaline (DNT) being identified as a novel inhibitor of AR function. DNT showed potent inhibition of… More > Graphic Abstract

Abraham Lamboro^1,3,*, Songnan Yang¹, Xueying Li¹, Dan Yao², Jun Zhang^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.9, pp. 2489-2501, 2023, DOI:10.32604/phyton.2023.029492

Abstract The effect of beta-lactam antibiotics on shoot induction and plantlet regeneration from cotyledonary nodes was tested using two peanut cultivars. The culture media contained 4 mg/L 6-benzylaminopurine (BAP) as the main growth regulator. Various concentrations (100–600 mg/L) of cefotaxime, carbenicillin, and timentin were applied in the culture media. In all the tested media, there were no significant differences in the shoot induction as compared to the control. However, little phytotoxic effect was observed at higher concentrations of these antibiotics in the shoot elongation media. Under shoot elongation medium, shoots turned brownish and partly died at higher concentrations where shooting rates… More >

MOHAMED SALEM^1,2, MOHAMMAD EL-METWALLY³, WESAMELDIN SABER^4,*, SALLY NEGM^5,6, ATTALLA EL-KOTT^7.8, YASSER MAZROUA^9,10, ABEER MAKHLOUF¹¹, MAHMOUD MOUSTAFA^7,12

BIOCELL, Vol.46, No.8, pp. 1979-1988, 2022, DOI:10.32604/biocell.2022.019301

Abstract Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various systems. Because of the emergence of novel viruses all the time and the inadequate of vaccines and antivirals, viral contagions are amongst the most causative diseases affecting people worldwide. Fungi exemplify a massive source of bioactive molecules as, many fungal secondary metabolities like Oxoglyantrypine, Carneic acid F, Scedapin C, Asteltoxin E, Phomanolide, Norquinadoline A and Quinadoline B have antiviral activity. This review deals with how secondary metabolites of fungi can help in the war against viruses in general and especially… More >

Mercedes Georgina Ramírez-Aragón¹, Victoria Jared Borroel-García¹, Ramón Valenzuela-Soto¹, Ricardo David Valdez-Cepeda², Francisco Javier Wong-Corral³, José Luis García-Hernández^4,*

Phyton-International Journal of Experimental Botany, Vol.90, No.2, pp. 533-541, 2021, DOI:10.32604/phyton.2021.013166

Abstract The extraction of bioactive compounds has become one of the most interesting areas of modern chemistry. For therapeutic reasons, it´s important to obtain antimicrobial agents from natural origin. The objective of the present study was to determine the inhibitory effect of ethanolic extract of basil (Ocimum basilicum L. var. Red Rubin) subjected to different concentrations of potassium (K⁺) on the activity of three bacterial strains that are pathogens in humans. Susceptibility was evaluated by inhibition surface and these results were compared to two antibiotics: Gentamicin (GE) and Ciprofloxacin (CPF) for their efficacy against each bacterial strain. Analyzed variables presented significant… More >