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Search Results (126)
  • Open Access

    ARTICLE

    Anemarsaponin B mitigates acute pancreatitis damage in mice through apoptosis reduction and MAPK pathway modulation

    YI HU1,#, ZHONGYANG REN2,#, ZHENGZHONG ZHAO1, YONGJIA HUANG3, WANTING HUANG3, JIE LIU3,*, LING DING3,*

    BIOCELL, Vol.48, No.5, pp. 745-758, 2024, DOI:10.32604/biocell.2024.049140

    Abstract Background: Acute pancreatitis (AP), known for its rapid onset and significant incidence and mortality rates, presents a clinical challenge due to the limited availability of effective treatments and preventive measures. Anemarsaponin B (ASB) has emerged as a potential therapeutic agent, demonstrating capabilities in reducing immune inflammation, positioning it as a promising candidate for AP treatment. Methods: We investigated the effects of ASB on AP in mice, induced by caerulein and lipopolysaccharide (LPS). Peripheral blood samples were collected 24 h post-induction with caerulein to assess of key biomarkers including lipase, amylase, TNF-α, IL-1β, IL-6, SOD, and… More >

  • Open Access

    ARTICLE

    3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

    XIAOQI WU1,2,#, YECHUAN HE1,2,#, YEQIN YUAN4, XIAN TAN1,2, LIN ZHU1,2, DANLING WANG1,2,4, BINYUAN JIANG3,4,*

    BIOCELL, Vol.48, No.5, pp. 861-872, 2024, DOI:10.32604/biocell.2024.048758

    Abstract Background: Nasopharyngeal carcinoma (NPC) exhibits a significant prevalence in the southern regions of China, and paclitaxel (PTX) is frequently employed as a medication for managing advanced NPC. However, drug resistance is typically accompanied by a poor prognosis. Exploring the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment efficacy. Methods: This study investigated whether 3-Methyladenine (3-MA) could potentiated the effect of PTX and its potential molecular mechanism. Samples were divided into the following categories: Negative control (NC) with the solvent dimethyl sulfoxide (DMSO, 0.5% v/v), PTX (400 nM), 3-MA… More >

  • Open Access

    ARTICLE

    Knockdown of RCN1 contributes to the apoptosis of colorectal cancer via regulating IP3R1

    XUAN SHI1,2, YUFEN WANG1, CHENYU LI1, WANGSHU FU3, XINYUE ZHANG3, AIXIA GONG1,*

    BIOCELL, Vol.48, No.5, pp. 835-845, 2024, DOI:10.32604/biocell.2024.048076

    Abstract Background: The incidence of colorectal cancer (CRC) has been increasing in recent years. Thus, the discovery of factors that can assist in alleviating CRC is urgently warranted. Methods: To identify a potential factor involved in the development of CRC, we screened the upregulated genes in tumor tissues through four datasets from an online database. The expression of reticulocalbin 1 (RCN1), a Ca-binding protein, was upregulated in the four datasets. Based on loss-of-function experiments, the effect of RCN1 on cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay. The regulatory effect of RCN1 on apoptosis… More > Graphic Abstract

    Knockdown of RCN1 contributes to the apoptosis of colorectal cancer via regulating IP3R1

  • Open Access

    ARTICLE

    Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

    JINGJING CHEN1, DAN WANG2, ZEQUN WANG2, MENGYUAN HAN4, HOUQING YIN2, WENTING ZHOU4, RIBAI YAN5, YAN PAN2,3,*

    Oncology Research, Vol.32, No.5, pp. 911-923, 2024, DOI:10.32604/or.2023.042384

    Abstract Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-PDT. Our results show that DTP-PDT inhibited cell growth and induced ROS… More > Graphic Abstract

    Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

  • Open Access

    ARTICLE

    Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma

    YANAN MA1, SHANSHAN WANG2,*, HUIGUO DING1,*

    BIOCELL, Vol.48, No.3, pp. 463-471, 2024, DOI:10.32604/biocell.2024.048244

    Abstract Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality worldwide. Although cystathionine-gamma-lyase (CSE) plays an important role in the development of multiple tumors, the clinical implication and potential mechanisms of CSE in HCC development remain elusive. Methods: In our study, the CSE expression in HCC was analyzed in Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets and further confirmed by RT-qPCR and immunohistochemistry assays in HCC samples. Furthermore, the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated… More >

  • Open Access

    ARTICLE

    SENEX-mediated CDK4/6 inhibition promotes senescence and confers apoptosis resistance in B-cell non-Hodgkin lymphoma

    JIYU WANG1,#, LIUYING YI2,#, KEKE HUANG1, YANGYANG WANG1, HUIPING WANG1, ZHIMIN ZHAI1,*

    BIOCELL, Vol.48, No.3, pp. 453-462, 2024, DOI:10.32604/biocell.2024.047871

    Abstract Background: The primary cause of treatment failure in patients with refractory or relapsed B-cell non-Hodgkin lymphoma (r/r B-NHL) is resistance to current therapies, and therapy-induced senescence (TIS) stands out as a crucial mechanism contributing to tumor drug resistance. Here, we analyzed SENEX/Rho GTPase Activating Protein 18 (ARHGAP18) expression and prognostic significance in doxorubicin-induced B-NHL-TIS model and r/r B-NHL patients, investigating its target in B-NHL cell senescence and the effect of combining specific inhibitors on apoptosis resistance in B-NHL-TIS cells. Methods: Raji cells were transfected with the human SENEX shRNA recombinant lentiviral vector (Sh-SENEX) and the empty vector… More >

  • Open Access

    ARTICLE

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

    JINGLONG CAO1,#, SHUMEI LI2,#, TONG ZHANG1,#, JIAN LIU1, WENSHUANG HOU1, ANQI WANG1, CHANG WANG3,4,*, CHENGHAO JIN1,3,5,*

    BIOCELL, Vol.48, No.2, pp. 313-325, 2024, DOI:10.32604/biocell.2023.043474

    Abstract Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity. However, its precise molecular mechanism in cancer cells was still unclear. This study investigated the effect of Val on gastric cancer (GC) cells and its potential molecular mechanism. Methods: Cell viability was examined by CCK-8 assay. Cell cycle, apoptosis, and Reactive oxygen species (ROS) level were analyzed by flow cytometry. The migration effect of Val on AGS cells was analyzed by transwell and wound-healing assay. The expression levels of proteins were analyzed by western blot. Results: The cell viability assay results demonstrated… More > Graphic Abstract

    Valtrate exerts anticancer effects on gastric cancer AGS cells by regulating reactive oxygen species-mediated signaling pathways

  • Open Access

    ARTICLE

    Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

    ZHI ZHANG1,#, XIAOSONG LI1,2,#, YING ZHANG1,2,#, HAO ZHU1,2, ZHENGUO QIAO3, YANG LU4, XIUWEI MI4, HUIHUA CAO5, GENHAI SHEN1,*, SONGBING HE4,*

    Oncology Research, Vol.32, No.2, pp. 353-360, 2024, DOI:10.32604/or.2023.042986

    Abstract Colorectal cancer (CRC) stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally. Absent in melanoma 2 (AIM2), a constituent of the interferon-inducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family, contributes to both cancer progression and inflammasome activation. Despite this understanding, the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive. Consequently, this study endeavors to assess AIM2’s expression levels, explore its potential antitumor effects, elucidate associated cancer-related processes, and decipher the underlying signaling pathways in CRC. More > Graphic Abstract

    Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

  • Open Access

    ARTICLE

    Inhibition of Ehrlich ascites carcinoma growth by melatonin: Studies with micro-CT

    SEHER YILMAZ1,2,*, ZÜLEYHA DOĞANYIĞIT3, MERT OCAK4, EVRIM SUNA ARIKAN SÖYLEMEZ5, ASLI OKAN OFLAMAZ3, SÜMEYYE UÇAR6, ŞÜKRÜ ATEŞ1, AMMAD AHMAD FAROOQI7

    Oncology Research, Vol.32, No.1, pp. 175-185, 2024, DOI:10.32604/or.2023.042350

    Abstract Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling pathway. Melatonin has many benefits, such as organizing circadian rhythms and acting as a powerful hormone. We aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin (mTOR) signaling pathway and the Argyrophilic Nucleolar Regulatory Region (AgNOR), using the Microcomputed Tomography (Micro CT). Ehrlich ascites carcinoma (EAC) cells were administered into the mice by subcutaneous injection. Animals with solid tumors were injected… More > Graphic Abstract

    Inhibition of Ehrlich ascites carcinoma growth by melatonin: Studies with micro-CT

  • Open Access

    ARTICLE

    Anti-proliferative effect of Annona extracts on breast cancer cells

    MARIA-LUISA VEISAGA1,2, MARIAM AHUMADA2, STACY SORIANO2, LEONARDO ACUNA3, WEI ZHANG3, IVY LEUNG2, ROBERT BARNUM2, MANUEL A. BARBIERI1,2,3,4,5,*

    BIOCELL, Vol.47, No.8, pp. 1835-1852, 2023, DOI:10.32604/biocell.2023.029076

    Abstract Backgorund: Fruits and seed extracts of Annona montana have significant cytotoxic potential in several cancer cells. This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. Methods: MTT assay was performed to determine the proliferation of cancer cells. Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. Protein expression and phosphorylation were determined by western blotting analysis to examine the underlying cellular mechanism… More >

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