Sehrish Bibi^1,*, Vincenzo Minutolo², Obaid Ullah Mehmood³, Renato Zona²

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.10, pp. 2473-2493, 2025, DOI:10.32604/fdmp.2025.072470 - 30 October 2025

Abstract Arterial stenosis is a critical condition with increasing prevalence among pediatric patients and young adults, making its investigation highly significant. Despite extensive studies on blood flow dynamics, limited research addresses the combined effects of nanoparticles and arterial curvature on unsteady pulsatile flow through multiple stenoses. This study aims to analyze the influence of nanoparticles on blood flow characteristics in realistic curved arteries with mild to severe overlapped constrictions. Using curvilinear coordinates, the thermal energy and momentum equations for nanoparticle-laden blood were derived, and numerical results were obtained through an explicit finite difference method. Key findings More >

Yifan Li^1,#, Xu Huang^2,#, Bingyu Ma³, Ling Sun¹, Shushui Wang¹, Zhiwei Zhang¹, Yumei Xie^1,*

Congenital Heart Disease, Vol.20, No.4, pp. 463-475, 2025, DOI:10.32604/chd.2025.068286 - 18 September 2025

Abstract Objective: The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis (PAS) in pediatric patients after surgical repair of complicated congenital heart diseases (CHDs). Methods: All pediatric patients diagnosed with residual PAS after surgical repair of complicated CHDs between 1996 and 2020 were retrospectively enrolled in the study. Results: A total of 41 patients (30 males, 11 females; median age 5.0 years, median weight 17 kg) were followed-up for a median of 7.1 years. Follow-up echocardiography results demonstrated that the target vessel diameter increased from… More >

Guozhen Wang^1,2, Yong An^1,2,*

Congenital Heart Disease, Vol.20, No.3, pp. 347-355, 2025, DOI:10.32604/chd.2025.065354 - 11 July 2025

Abstract Background: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomalous coronary artery origin disorder. Objective: We sought to summarize the clinical experience and prognostic characteristics of surgical treatment of ALCAPA. Methods: We retrospectively analyzed clinical information on patients who had ALCAPA and underwent surgery at our center from February 2016 to October 2023. Results: This comparative study of 23 ALCAPA patients (9 infants <1 year; 14 children >1 year) demonstrated significant age-dependent outcomes. Infant patients exhibited markedly prolonged mechanical ventilation (183 ± 105.6 vs. 48.5 ± 62.2 min, p =… More >

Chenyu Jiang, Hao Zhang^*

Congenital Heart Disease, Vol.20, No.2, pp. 129-131, 2025, DOI:10.32604/chd.2025.064155 - 30 April 2025

Abstract This article has no abstract. More >

Yaqi Zhang^1,#, Liang Hu^1,#, Yuxi Zhang¹, Bo Qian¹, Jirong Qi^1,2, Wei Peng^1,2,*

Congenital Heart Disease, Vol.20, No.1, pp. 55-60, 2025, DOI:10.32604/chd.2025.063072 - 18 March 2025

Abstract Background: Carotid artery pseudoaneurysm in children is rare; typically caused by trauma; surgical interventions and infection. These aneurysms can lead to significant neurological and vascular risks; and their management remains challenging. While endovascular therapy has become the standard for giant pseudoaneurysms in adults; its use in children is limited. No established guidelines or long-term safety data exist for pediatric endovascular treatment. We present a child who developed a carotid artery pseudoaneurysm after venoarterial extracorporeal membrane oxygenation (VA-ECMO) support and heart transplantation; highlighting the management strategies and outcomes. Case Description: A 4-year-old boy with dilated cardiomyopathy was admitted… More >

Haris Alam Zuberi¹, Madan Lal¹, Amol Singh¹, Nurul Amira Zainal^2,3,*, Ali J. Chamkha⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1839-1864, 2025, DOI:10.32604/cmes.2024.056661 - 27 January 2025

Abstract Nanotechnology holds immense importance in the biomedical field due to its ability to revolutionize healthcare on a molecular scale. Motivated by the imperative of enhancing patient outcomes, a comprehensive numerical simulation study on the dynamics of blood flow in a stenosed artery, focusing on the effects of copper and alumina nanoparticles, is conducted. The study employs a 2-dimensional Newtonian blood flow model infused with copper and alumina nanoparticles, considering the influence of a magnetic field, thermal radiation, and various flow parameters. The governing differential equations are first non-dimensionalized to facilitate analysis and subsequently solved using… More >

Mohamed Aashiq Abdul Ghayum^1,*, Maria Kiaffas^1,2, Ashley Warta¹, Melanie Kathol¹, David C. Mundy², Kelsey Brattrud¹, Nitin Madan^1,2

Congenital Heart Disease, Vol.19, No.6, pp. 647-651, 2024, DOI:10.32604/chd.2025.058271 - 27 January 2025

Abstract Prominent coronary artery (CA) flow observed on a fetal echocardiogram has been associated with fetal growth restriction and myocardial dysfunction. We present two cases with this finding, in the presence of congenital heart disease (CHD) and absence of growth restriction or myocardial dysfunction. Both the cases rapidly progressed to extremis, necessitating emergent delivery. Our cases highlight the importance of recognizing prominent CA flow in fetuses with CHD as a potential marker for in utero distress. More >

Domenico Crea¹, Arben Dedja¹, Matteo Ponzoni^1,2, Stefania Rizzo³, Alberto Cipriani⁴, Riccardo Bariani⁴, Kalliopi Pilichou³, Maria Bueno Marinas³, Danila Azzolina⁵, Massimo A. Padalino^1,6,*

Congenital Heart Disease, Vol.19, No.5, pp. 473-487, 2024, DOI:10.32604/chd.2025.057014 - 31 December 2024

Abstract Background: Since 2015, the pulmonary artery banding (PAB), following the Giessen protocol, has treated end-stage heart failure in selected infants with preserved right ventricular function, acting as a bridge to transplant or recovery, as a result of ventricular-ventricular interaction. Objectives: To elucidate whether PAB is a feasible and reproducible procedure in a rodent model of pharmacologically induced dilated cardiomyopathy (DCM) and to evaluate PAB-induced ventricular rehabilitation. Methods: We used 49 Sprague-Dawley rats divided into four groups: a sham surgery control group, a healthy animal group undergoing PAB, a doxorubicin (DOX)- treated control group, and a DOX… More >

SAM SON¹, AKSHAAR BRAHMBHATT¹, KEN ZHAO¹, BRETT MARINELLI¹, JAMES HARDING², WILLIAM JARNAGIN³, GHASSAN K. ABOU-ALFA², HOOMAN YARMOHAMMADI^1,*

Oncology Research, Vol.32, No.12, pp. 1831-1836, 2024, DOI:10.32604/or.2024.052985 - 13 November 2024

Abstract Background: This article aims to present the single-institution outcomes of patients with Fibrolamellar Carcinoma (FLC) treated with liver-directed therapies (LDT). Methods: In this single-center retrospective study, all patients diagnosed with FLC who underwent LDT were identified. Between July 2012 and July 2023, six patients were identified. One patient was excluded due to bleeding. Demographic and clinical parameters were recorded. Complications within 30 days of the LDT were evaluated. Radiological treatment responses at 1, 6, and 12 months were assessed per mRECIST. Results: A total of five patients, which included three females and two males, were reviewed.… More >

Lei Wang^1,*, Blanca Rodriguez², Xiaoyu Luo³, Charles Augarde⁴

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.013350

Abstract Cardiovascular disease is the leading cause of death worldwide. Disease-specific software, like FFRct from HeartFlow, and high-fidelity computational models within a general-purpose software, like Living Heart Project within Abaqus, are essential to revolutionise diagnosis and treatment of cardiovascular disease for clinicians and design of medical devices for industries. This talk presents our past researches on computational modelling of tear propagation in the aortic dissection [1-2] and of electromechanical coupling in the human heart with the finite element method [3], and our current exploration on high-fidelity and efficient computation and software development for diagnosis and treatment More >