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  • Open Access

    ABSTRACT

    Automated Segmentation of Atherosclerotic Plaque Using Bayes Classifier for Multi-Contrast In Vivo and Ex Vivo MR Images

    Xueying Huang1, Chun Yang2, Jie Zheng3, Pamela K. Woodard3, Dalin Tang1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.1, No.1, pp. 29-34, 2007, DOI:10.3970/icces.2007.001.029

    Abstract Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. Accurate identification of plaque components will improve the accuracy and reliability of computational models. In this article, we present a segmentation method using a cluster analysis technique to quantify and classify plaque components from magnetic resonance images (MRI). 3D in vivo and ex vivo multi-contrast (T1-, proton density-, and T2-weighted) MR Images were acquired from a patient of cardiovascular disease. Normal distribution Bayes classifier was performed on ex vivo and in vivo MR Images respectively. The resulting segmentation More >

  • Open Access

    ARTICLE

    In Vivo/Ex Vivo MRI-Based 3D Non-Newtonian FSI Models for Human Atherosclerotic Plaques Compared with Fluid/Wall-Only Models

    Chun Yang1, Dalin Tang2, Chun Yuan3, Thomas S. Hatsukami4, Jie Zheng5, Pamela K. Woodard5

    CMES-Computer Modeling in Engineering & Sciences, Vol.19, No.3, pp. 233-246, 2007, DOI:10.3970/cmes.2007.019.233

    Abstract It has been recognized that fluid-structure interactions (FSI) play an important role in cardiovascular disease initiation and development. However, in vivo MRI multi-component FSI models for human carotid atherosclerotic plaques with bifurcation and quantitative comparisons of FSI models with fluid-only or structure-only models are currently lacking in the literature. A 3D non-Newtonian multi-component FSI model based on in vivo/ex vivo MRI images for human atherosclerotic plaques was introduced to investigate flow and plaque stress/strain behaviors which may be related to plaque progression and rupture. Both artery wall and plaque components were assumed to be hyperelastic,… More >

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