Caiping Huang^*, Zihan Huang, Wenfeng You

Structural Durability & Health Monitoring, Vol.18, No.3, pp. 299-320, 2024, DOI:10.32604/sdhm.2024.047850 - 15 May 2024

Abstract This paper presents an easily installed improved perfobond connector (PBL) designed to reduce the shear concentration of PBL. The improvement of PBL lies in changing the straight penetrating rebar to the Z-type penetrating rebar. To study the shear performance of improved PBL, two PBL test specimens which contain straight penetrating rebar and six improved PBL test specimens which contain Z-type penetrating rebars were designed and fabricated, and push-out tests of these eight test specimens were carried out to investigate and compare the shear behavior of PBL. Additionally, Finite Element Analysis (FEA) models of the PBL… More >

KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278 - 23 April 2024

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive More > Graphic Abstract

XUHUI ZHAO^1,2, XIAOMIN HUANG¹, CHUNYAN DANG², XIA WANG¹, YUJIAO QI³, HONGLING LI^2,*

Oncology Research, Vol.32, No.5, pp. 999-1009, 2024, DOI:10.32604/or.2024.046679 - 23 April 2024

Abstract Background: EBV-miR-BARTs exhibit significant relevance in epithelial tumors, particularly in EBV-associated gastric and nasopharyngeal cancers. However, their specific mechanisms in the initiation and progression of gastric cancer remain insufficiently explored. Material and Methods: Initially, EBV-miRNA-BART6-5p and its target gene SMAD4 expression were assessed in EBV-associated gastric cancer tissues and cell lines. Subsequent transfection induced overexpression of EBV-miRNA-BART6-5p in AGS and MKN-45, and downregulation in EBV-positive cells (SUN-719). The subsequent evaluation aimed to observe their impact on gastric cancer cell proliferation, migration, and glycolytic processes, with the TGF-β/SMAD4 signaling pathway value clarified using a TGF-β inhibitor. Results:… More >

Liliane Nga¹, Benoit Ndiwe^1,2, Achille Bernard Biwolé¹, Antonio Pizzi^3,*, Jean Jalin Eyinga Biwole¹, Joseph Zobo Mfomo¹

Journal of Renewable Materials, Vol.12, No.3, pp. 553-568, 2024, DOI:10.32604/jrm.2023.046568 - 11 April 2024

Abstract Extracts of plant origin, particularly tannins, are attracting growing interest for the sustainable development of materials in the industrial sector. The discovery of new tannins is therefore necessary. The aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALDI-TOF/MS and Carbon 13 Nuclear Magnetic Resonance (¹³C NMR). The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined, as was the mechanical strength of the resin hardened with Acacia nilotica extracts. Yield by successive water extraction was 35%. MALDI-TOF/MS… More >

Andrei Vasiliev, Andrei Sukhanovskii^*, Elena Popova

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 739-748, 2024, DOI:10.32604/fdmp.2024.048092 - 28 March 2024

Abstract The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is studied. Convection is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the sidewall. The horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex structure. The mean meridional circulation, consisting of three cells, provides a strongly non-uniform differential rotation. As a result of the instability of the main cyclonic zonal flow, the train of baroclinic waves appears… More >

HUAN HU^1,2,*, YUE HUANG¹, FANGZHOU LIU¹, QIAN WANG^1,2, YANZI YAO^3,*

BIOCELL, Vol.48, No.3, pp. 353-362, 2024, DOI:10.32604/biocell.2024.048311 - 15 March 2024

Abstract Increasing life expectancy and an aging population lead to age-related bone diseases like osteoporosis and low bone mass more prevalent. These conditions represent a common, costly and chronic burden, not only for elderly but also to society at large. Consequently, elucidating the pathophysiology and developing effective therapies for these diseases is of paramount importance. Recent advances in research have identified the gut as a novel and promising target for addressing bone disorders, giving rise to the concept of the “gut-bone axis”. An in-depth review of the latest insights into the effects of age-related physiological changes More >

Yu Huang¹, Beilei Liu¹, Dianlei Feng^2,*, Hao Shi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1679-1699, 2024, DOI:10.32604/cmes.2023.044094 - 29 January 2024

Abstract Rigid barrier deflectors can effectively prevent overspilling landslides, and can satisfy disaster prevention requirements. However, the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation. To date, few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention. To investigate the effect of rigid barrier deflectors on impact mechanisms, a numerical model using the smoothed particle hydrodynamics (SPH) method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors. This model was validated… More > Graphic Abstract

Ismail Shah^1,2, Jing Li^1,3,4,*, Nauman Khan⁵, Hamad R. Almujibah⁶, Muhammad Mudassar Rehman², Ali Raza⁷, Yun Peng^3,4

Journal of Renewable Materials, Vol.12, No.1, pp. 167-186, 2024, DOI:10.32604/jrm.2023.031503 - 23 January 2024

Abstract Recycled steel fiber reinforced concrete is an innovative construction material that offers exceptional mechanical properties and durability. It is considered a sustainable material due to its low carbon footprint and environmental friendly characteristics. This study examines the key influencing factors that affect the behavior of this material, such as the steel fiber volume ratio, recycled aggregate replacement rate, concrete strength grade, anchorage length, and stirrup constraint. The study investigates the bond failure morphology, bond-slip, and bond strength constitutive relationship of steel fiber recycled concrete. The results show that the addition of steel fibers at 0.5%,… More >

Francisco Zarate¹, Thibault Villette², Xavier Martinez^1,3, Fernando Rastellini Canela¹, David Cendón⁴, Carmen Andrade⁵, Eugenio Oñate^1,3

Revista Internacional de Métodos Numéricos para Cálculo y Diseño en Ingeniería, Vol.39, No.2, pp. 1-13, 2023, DOI:10.23967/j.rimni.2023.05.001 - 04 May 2023

Abstract We present a combination of three dimensional (3D) solid elements and rotation-free beam elements for non-linear analysis of fiber-reinforced polymer (FRP) of rebars. The matrix material is modelled by 3D solid elements while the fibers are modelled with rotation-free beam elements. The absence of rotation variables in the beam elements allows the straightforward coupling of 3D solid and beam elements using a formulation with displacement nodal degrees of freedom only. Both solid and beam elements are formulated in an updated Lagrangian description. The behavior of the matrix and the fiber material are modelled with an More >

Cesar Hernandez¹, Jhanie Rodriguez²

Revista Internacional de Métodos Numéricos para Cálculo y Diseño en Ingeniería, Vol.39, No.2, pp. 1-6, 2023, DOI:10.23967/j.rimni.2023.05.006 - 31 May 2023

Abstract "This work aims to develop a computational tool for synthesizing a four-bar linkage mechanism that can generate a prescribed path for a point coupler link to follow. The dimensional synthesis of the mechanism involves determining the lengths of each of its links. In this case, two possible configurations are evaluated: crank-rocker and/or double crank. The prescribed path consists of an arbitrary number of points contained in a plane, along with the corresponding rotation degrees of the driver element.'' Dimensioning the mechanism involves many variables, and it is possible to obtain various configurations that generate paths… More >