MIRIAM TERUEL1,2, JAQUELINE D’ERCOLE1 AND RODOLFO CATALANO2
BIOCELL, Vol.35, No.1, pp. 29-34, 2011, DOI:10.32604/biocell.2011.35.029
Abstract Benzimidazole compounds are used in both humans and animals for controlling helminth
parasites. Albendazole has teratogenic effects attributed to its active metabolite albendazole sulphoxide. The
aim of this work was to evaluate the effect of the latter compound when administered to pregnant CF1 mice
during the preimplantation period. Females were superovulated by intraperitoneal injection of 10 IU of eCG
and 10 IU of hCG (48h later) and were paired with males of proven fertility. Albendazole sulphoxide (200
mg/kg) was orally administered by gavages at day 1, 2 or 3 of pregnancy; the control group received only the
vehicle (carboxymethylcellulose). Females… More >
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