Manisha Choudhari¹, Shantanu Damle², Rajat Vashist¹, Ranendra Narayan Saha³, Sunil Kumar Dubey⁴, Gautam Singhvi^1,*

Journal of Polymer Materials, Vol.42, No.4, pp. 1199-1229, 2025, DOI:10.32604/jpm.2025.072987 - 26 December 2025

Abstract Abiraterone acetate (ABTA) was approved by the USFDA in 2011 for treating metastatic castration-resistant prostate cancer (mCRPC). ABTA exhibits poor aqueous solubility, inadequate dissolution, low oral bioavailability (<10%), and significant positive food effects. To overcome these limitations, in the present work, ABTA solid dispersions (SDs) were developed by using hot melt extrusion technology (HME) with various grades of hydroxypropyl methylcellulose HME (HPMC HME 15LV and 100LV) at different extrusion temperatures. HPMC HME demonstrated the ability to prevent drug precipitation for up to 120 min compared to the free drug (10 min), sustaining the supersaturation state… More > Graphic Abstract

Misbah Naz¹, Rubab Shabbir^2,17, Krishan K. Verma³, Anshu Rastogi⁴, Vishnu D. Rajput⁵, Talha Javed^2,6, Muhammad Ammar Raza⁷, Kainat Asif⁸, Muhammad Aamir Iqbal⁹, Muhammad Imran¹⁰, Mohammad Sohidul Islam¹¹, Khalid Rehman Hakeem^12,13,*, Mehmet Firat Baran¹⁴, Ayman EL Sabagh^15,16,*

Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 915-927, 2022, DOI:10.32604/phyton.2022.018688 - 24 January 2022

Abstract

Under changing climate, trace elements like selenium (Se) have emerged as vital constituent of agro-ecosystems enabling crop plants to off-set the adverse effects of suboptimal growth conditions. The available form of selenium is important for boosting its bioavailability to crop plants having varied agro-botanical traits and root architectural systems. As compared to selenite, the selenate has a weaker soil bonding, higher absorption in the soil solution which results in a comparatively absorption by plant roots. Various factors including dry climate, high pH, optimal ambient air temperature, less accumulation of water, and low concentration of organic

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Ramachandran Vinyagam¹, Pradeep Kumar², Kyung Eun Lee^1,3, Baojun Xu⁴, Muhammad Nurul Matin^5,*, Sang Gu Kang^1,3,*

Phyton-International Journal of Experimental Botany, Vol.90, No.1, pp. 1-15, 2021, DOI:10.32604/phyton.2020.013388 - 20 November 2020

Abstract Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and disorders. Wedelolactone (WDL), a major bioactive compound in Eclipta prostrata L (Eclipta alba L), has been reported with potential benefits in human health against chronic diseases. However, a comprehensive study on WDL pharmacological benefits in various ailments, to the best of our knowledge, is not yet reported. Thereof, the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases, including cardiovascular, More >