LAZAR S. POPOVIC^1,2,*, GORANA MATOVINA-BRKO¹, MAJA POPOVIC^1,2, KEVIN PUNIE³, ANA CVETANOVIC^4,5, MATTEO LAMBERTINI^6,7

Oncology Research, Vol.31, No.3, pp. 221-238, 2023, DOI:10.32604/or.2023.028525

Abstract Triple-negative breast cancer (TNBC) is a disease with often an aggressive course and a poor prognosis compared to other subtypes of breast cancer. TNBC accounts for approximately 10%–15% of all diagnosed breast cancer cases and represents a high unmet need in the field. Up to just a few years ago, chemotherapy was the only systemic treatment option for this subtype (1). To date, TNBC is considered a heterogeneous disease. One of the existing classifications is based on the analysis of mRNA expression in 587 TNBC cases, in which Lehman et al. proposed six subtypes of TNBC as follows: two basal-like… More > Graphic Abstract

SHUIZHONG CEN^1,#, XIAOJIE PENG^2,#, JIANWEN DENG^3,#, HAIYUN JIN⁴, ZHINAN DENG⁵, XIAOHUA LIN³, DI ZHU³, MING JIN⁶, YANWEN ZHU³, PUSHENG ZHANG³, YUNFENG LUO³, HONGYAN HUANG^3,*

Oncology Research, Vol.31, No.3, pp. 375-388, 2023, DOI:10.32604/or.2023.028256

Abstract Triple-negative breast cancer (TNBC) is characterized by fast growth, high metastasis, high invasion, and a lack of therapeutic targets. Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression. It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors, but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown. In this study, we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1 (PLK1) activation and participating in mitosis of TNBC cells. We detected the expression of AFAP1-AS1 in the TNBC patient cohort and… More > Graphic Abstract

FRANCISCO RAÚL BORZONE^1,*, MARÍA BELÉN GIORELLO¹, LEANDRO MARCELO MARTINEZ², MARÍA CECILIA SANMARTIN^1,3, LEONARDO FELDMAN⁴, FEDERICO DIMASE⁵, EMILIO BATAGELJ⁶, GUSTAVO YANNARELLI³, NORMA ALEJANDRA CHASSEING^1,*

Oncology Research, Vol.31, No.3, pp. 361-374, 2023, DOI:10.32604/or.2023.028104

Abstract Breast cancer is the predominant form of carcinoma among women worldwide, with 70% of advanced patients developing bone metastases, with a high mortality rate. In this sense, the bone marrow (BM) mesenchymal stem/stromal cells (MSCs) are critical for BM/bone homeostasis, and failures in their functionality, transform the BM into a pre-metastatic niche (PMN). We previously found that BM-MSCs from advanced breast cancer patients (BCPs, infiltrative ductal carcinoma, stage III-B) have an abnormal profile. This work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.… More >

T. Normandin, A. Stulz

Psycho-Oncologie, Vol.16, No.3, pp. 295-302, 2022, DOI:10.3166/pson-2022-0210

Abstract This paper presents our research thesis with the aim of obtaining the interuniversity diploma of sexology.
Aim: The objective of our research is to observe the link between the sense of “we-ness, we-disease” and the sexual resilience of the couple facing breast cancer.
Procedure: The methodology was qualitative and observational. Five couples were included in the study and participated in a couple interview. The transcription of research interviews was analyzed using the “We-ness coding scale” (Reid) and a thematic content analysis of intimate and sexual life of the five couples.
Results: For three couples, the content analysis of the interviews… More >

KAIMIN FAN, JUNWEI WENG^*

BIOCELL, Vol.47, No.6, pp. 1199-1211, 2023, DOI:10.32604/biocell.2023.028516

Abstract Immunotherapy targets the dysfunctional immune system to induce cancer cell killing by CD8-positive T cells. Immune checkpoint inhibitors (ICIs), specifically anti-PD-1 antibodies, anti-PD-L1 antibodies, and anti-CTLA4 antibodies, have revolutionized the management of many malignancies due to their significant role in generating a durable clinical response. However, clinical data suggest that response rates to ICI monotherapy are low due to the immunologically silent characteristics of breast cancer (BC). Chemotherapy, surgery, radiotherapy, and targeted therapy were recently reported to alter the tumor microenvironment and enhance the ICI response. Some clinical studies supported that ICIs, in combination with other treatment strategies, show superior… More >

A. Guité-Verret, M. Vachon

Psycho-Oncologie, Vol.17, No.1, pp. 44-50, 2023, DOI:10.3166/pson-2022-0220

Abstract The aim of this study is to better understand the experience of breast cancer through the analysis of the metaphors in the narratives of women with breast cancer. The blogs of two women were selected and processed according to an interpretative phenomenological analysis. This analysis highlights three metaphors in light of which these women seemed to understand their experience: the body as a medical battlefield, the fragmented body, and the cancer journey. These findings underline the violent changes in the boundaries of the body and the subject that can occur during cancer treatment, as well as the need to integrate… More >

M. Karoui, R. Kamoun, H. Nefzi, N. Marrakchi, H. Raies, A. Mezlini, K. Meddeb, F. Ellouze

Psycho-Oncologie, Vol.17, No.1, pp. 31-37, 2023, DOI:10.3166/pson-2022-0211

Abstract Aim: The objective of this study is to investigate the prevalence of depression and anxiety in women Tunisian population followed for breast cancer and to identify the socio-demographic, clinical, and of couple relationship factors associated with them.
Procedure: Cross-sectional study on 100 patients followed for confirmed breast cancer. A questionnaire on the sociodemographic, clinical, therapeutic, conjugal, and sexual characteristics of the couple was completed. The HADS (Hospital Anxiety and Depression Scale) was used for the detection of anxiety and depressive symptoms.
Results: A clinical score was found in 48% of cases for anxiety and 37% of cases for depression. Patients… More >

Alia Alshehri, Duaa AlSaeed^*

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 939-970, 2023, DOI:10.32604/iasc.2023.037096

Abstract One of the most prevalent cancers in women is breast cancer. Early and accurate detection can decrease the mortality rate associated with breast cancer. Governments and health organizations emphasize the significance of early breast cancer screening since it is associated to a greater variety of available treatments and a higher chance of survival. Patients have the best chance of obtaining effective treatment when they are diagnosed early. The detection and diagnosis of breast cancer have involved using various image types and imaging modalities. Breast “infrared thermal” imaging is one of the imaging modalities., a screening instrument used to measure the… More >

E. Jenifer Sweetlin^*, S. Saudia

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 343-367, 2023, DOI:10.32604/iasc.2023.036742

Abstract This paper proposes a hybrid feature selection sequence complemented with filter and wrapper concepts to improve the accuracy of Machine Learning (ML) based supervised classifiers for classifying the survivability of breast cancer patients into classes, living and deceased using METABRIC and Surveillance, Epidemiology and End Results (SEER) datasets. The ML-based classifiers used in the analysis are: Multiple Logistic Regression, K-Nearest Neighbors, Decision Tree, Random Forest, Support Vector Machine and Multilayer Perceptron. The workflow of the proposed ML algorithm sequence comprises the following stages: data cleaning, data balancing, feature selection via a filter and wrapper sequence, cross validation-based training, testing and… More >

JINGYUE FU, RUI CHEN, ZHIZHENG ZHANG, JIANYI ZHAO, TIANSONG XIA^*

Oncology Research, Vol.31, No.2, pp. 157-167, 2023, DOI:10.32604/or.2023.027972

Abstract Background: Breast cancer has become the most common malignant tumor in the world. It is vital to discover novel prognostic biomarkers despite the fact that the majority of breast cancer patients have a good prognosis because of the high heterogeneity of breast cancer, which causes the disparity in prognosis. Recently, inflammatory-related genes have been proven to play an important role in the development and progression of breast cancer, so we set out to investigate the predictive usefulness of inflammatory-related genes in breast malignancies. Methods: We assessed the connection between Inflammatory-Related Genes (IRGs) and breast cancer by studying the TCGA database.… More > Graphic Abstract