WENLI JIANG^1,#, JUNYI SHEN^1,#, XIAOQIANG DU^1,#, YAN QIU¹, JIAN ZHONG¹, ZHI OUYANG¹, BINGMEI M. FU², YE ZENG^1,*

BIOCELL, Vol.47, No.10, pp. 2255-2263, 2023, DOI:10.32604/biocell.2023.030880

Abstract Background: Anisodine hydrobromide (AT3), an anti-cholinergic agent, could be delivered to the brain across the blood-brain barrier and has been used clinically for the treatment of cerebral ischemia/reperfusion injury. Endothelial dysfunction can be caused by hypoxia/reoxygenation (H/R) via oxidative stress and metabolic alterations. The present study investigated whether AT3 regulates the production of nitric oxide (NO) and reactive oxygen species (ROS), and the HIF-1α pathway via regulation of muscarinic acetylcholine receptors (mAChRs) in brain microvascular endothelial cells after H/R exposure. Methods: Under H/R conditions, hCMEC/D3 cerebral microvascular endothelial cells were treated with AT3. Specific inhibitors of M2- and M4- mAChRs… More > Graphic Abstract

Dariimaa Ganbat^1,2, Bat-Erdene Jugder³, Lkhamaa Ganbat⁴, Miki Tomoeda⁵, Erdenetsogt Dungubat^2,6, Ambaga Miyegombo⁷, Gantsetseg Garmaa⁸, Yoshihisa Takahashi⁶, Ryuji Fukuzawa⁶, Ichiro Mori⁶, Takayuki Shiomi⁶, Akinori Nakata⁹, Yasuhiko Tomita^6,*

Oncologie, Vol.24, No.2, pp. 195-225, 2022, DOI:10.32604/oncologie.2022.022299

Abstract Most cancer cells overexpress the anti-apoptotic protein survivin and display redox dysregulation originating from genotypic and phenotypic alterations. These disturbances contribute to the uncontrolled proliferation, invasion, and chemoresistance of cancer cells, yet they also represent a specific vulnerability that could be exploited therapeutically in selected tumors. YM155 (sepantronium bromide) is a naphthoquinone-containing imidazolebased compound that selectively inhibits survivin expression at the transcriptional and post-transcriptional levels. Here, we performed a systematic review and meta-analysis of clinical studies in which YM155 was administered as monotherapy or combination therapy for patients with cancer. We assessed fully or partially reported clinical outcomes and pharmacological… More >

Wen Xu¹, Dongdong Ren², Biyi Yi¹, Haoqing Zhen¹, Youbing Zhang^2,*, Xuesong Zhang³

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.2, pp. 1101-1123, 2022, DOI:10.32604/cmes.2022.019564

Abstract The Regional Integrated Energy System (RIES) has brought new modes of development, utilization, conversion, storage of energy. The introduction of Soft Open Point (SOP) and the application of Power to Gas (P2G) technology will greatly deepen the coupling of the electricity-gas integrated energy system, improve the flexibility and safety of the operation of the power system, and bring a deal of benefits to the power system. On this background, an optimal dispatch model of RIES combined cold, heat, gas and electricity with SOP is proposed. Firstly, RIES architecture with SOP and P2G is designed and its mathematical model also is… More >

NING LI^1,#, YANG CHEN^2,#, YONGJIE YANG^3,4, SHUHAN LYU¹, YUE PAN^1,5,*

BIOCELL, Vol.46, No.6, pp. 1473-1482, 2022, DOI:10.32604/biocell.2022.018278

Abstract Breast cancer is a highly aggressive cancer in females. Metastasis is a major obstacle to the efficient and successful treatment of breast cancer. Cetyltrimethylammonium bromide (CTAB) has anti-tumor effects on a variety of tumors. We showed that CTAB inhibits the metastasis of breast cancer to the lungs both in vitro and in vivo. Epithelial-mesenchymal transition (EMT) is thought to be one of the major processes mediating breast cancer metastasis. We found that CTAB suppressed EMT and regulated the levels of the classical EMT markers E-cadherin, N-cadherin, vimentin, Snail and Twist1. Moreover, as a candidate anti-tumor agent, CTAB showed primary safety… More >

ALI H. ABU ALMAATY¹, BASMA M. HENDAM², FAYEZ ALTHOBAITI³, EMAN FAYAD^3,*, YASMIN M. ABD EL-AZIZ¹

BIOCELL, Vol.46, No.1, pp. 219-234, 2022, DOI:10.32604/biocell.2022.017623

Abstract The hepatotoxic effect of potassium bromide (KBr) on rat liver tissues were determined, as well as the potential protective effect of Tegillaraca granosa (T. granosa) flesh body extract. Twenty adult male albino rats were equally distributed into four groups; Group (I) treated with physiological saline (control group), Group (II) was orally gavaged by 200 mg/kg of T. granosa body extract day after day, Group (III) was intoxicated by KBr (150 mg/kg bwt day after day orally) and finally, Group (IV) was given a combination of T. granosa flesh body extract plus KBr with similar doses in the second and third… More >

Mingyu Yu¹, Mengyuan Liu¹, Guangqian Luo^1,2,*, Ruize Sun¹, Jingyuan Hu¹, Hailu Zhu¹, Li Zhong³, Lipeng Han³, Xian Li¹, Hong Yao¹

Energy Engineering, Vol.118, No.5, pp. 1277-1286, 2021, DOI:10.32604/EE.2021.014810

Abstract The application of forced mercury oxidation technology would lead to an increase of Hg²⁺ concentration in the flue gas. Although Hg²⁺ can be easily removed in the WFGD, the mercury re-emission in the WFGD can decrease the total removal of mercury from coal-fired power plants. Hence, it is necessary to control Hg²⁺ concentration in the devices before the WFGD. Fly ash adsorbent is considered as a potential alternative for commercial activated carbon adsorbent. However, the adsorption efficiency of the original fly ash is low. Modification procedure is needed to enhance the adsorption performance. In this study, the adsorption of Hg²⁺… More >