S.J. Mousavi∗, M.H. Doweidar∗,†, M. Doblaré∗
Molecular & Cellular Biomechanics, Vol.10, No.1, pp. 1-25, 2013, DOI:10.3970/mcb.2013.010.001
Abstract Although there are several computational models that explain the trajectory that cells take during migration, till now little attention has been paid to the integration of the cell migration in a multi-signaling system. With that aim, a generalized model of cell migration and cell-cell interaction under multisignal environments is presented herein. In this work we investigate the spatio-temporal cell-cell interaction problem induced by mechano-chemo-thermotactic cues. It is assumed that formation of a new focal adhesion generates traction forces proportional to the stresses transmitted by the cell to the extracellular matrix. The cell velocity and polarization direction are calculated based on… More >
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