Xiaoning Qin¹, Liqing Yuan², Hongxun Ruan¹, Lin Lin¹

BIOCELL, Vol.43, No.2, pp. 89-98, 2019, DOI:10.32604/biocell.2019.06352

Abstract Interleukin-22 (IL-22) is a member of IL-10 cytokine family which is expressed in activated T cells predominantly and in activated natural killer cells at lower levels. Previous studies have demonstrated the link between elevated levels of IL-22 and disease severity of psoriasis, Crohn’s disease, rheumatoid arthritis and interstitial lung diseases. However, the function of IL-22 in the development and progression of colorectal cancer (CRC) remains elusive. In this study, we first evaluated the IL-22/IL-22R1 level in CRC patients, and found that tumor tissues have more active expression of IL-22 and IL-22R1 than normal tissues, presenting correlation with the degree of… More >

Liqiang Lin¹, Xianqiao Wang², Xiaowei Zeng^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.2, pp. 203-220, 2014, DOI:10.3970/cmes.2014.098.203

Abstract The Voronoi tessellation is employed to describe cellular patterns and to simulate cell division and cell remodeling in epithelial tissue. First, Halton sequence is utilized to generate the random generators of Voronoi cell points. The centroidal Voronoi cell center is obtained by probabilistic Lloyd's method and polygonal structure of cell distribution is modeled. Based on the polygonal shape of cells, the instantaneous mechanism of cell division is applied to simulate the cell proliferation and remodeling. Four kinds of single-cell division algorithms are designed with the consideration of cleavage angle. From these simulations, we find that cell topological structure varies case… More >