Eduard Belskikh^1,*, Yuliya Marsyanova², Denis Melnikov³, Oleg Uryasev¹, Valentina Zvyagina²

BIOCELL, Vol.49, No.11, pp. 2093-2123, 2025, DOI:10.32604/biocell.2025.069272 - 24 November 2025

Abstract Elevated homocysteine is a clinically relevant metabolic signal in chronic obstructive pulmonary disease (COPD). Higher circulating levels track with oxidative stress, endothelial dysfunction, mitochondrial impairment, and pulmonary vascular remodeling, rise with disease severity, and may contribute to the excess cardiovascular risk—although effect sizes and causality remain uncertain. This review centers on the homocysteine–carnitine relationship in COPD pathophysiology. Carnitine deficiency, prevalent in COPD, can worsen mitochondrial bioenergetics, promote accumulation of acyl intermediates, and reduce nitric oxide bioavailability via endothelial nitric oxide synthase uncoupling (eNOS). Conversely, restoring carnitine status in experimental and early clinical settings has been… More >

Stanislav Kotlyarov^1,*, Dmitry Oskin²

BIOCELL, Vol.49, No.9, pp. 1631-1661, 2025, DOI:10.32604/biocell.2025.066675 - 25 September 2025

Abstract Chronic obstructive pulmonary disease (COPD) and respiratory tuberculosis are important respiratory problems. Meeting together, these diseases can mutually worsen the severity of clinical manifestations and negatively affect prognosis. COPD and tuberculosis share a number of common risk factors and pathogenetic mechanisms involving various immune and non-immune cells. Inflammation, hypoxia, oxidative stress, and lung tissue remodeling play an important role in the comorbid course of COPD and respiratory tuberculosis. These mechanisms are of diagnostic interest and are promising therapeutic targets. Thus, the aim of the current review is to discuss the mechanisms of the comorbid course More >

Fahad Ahmad^1,2,*, Saad Awadh Alanazi³, Kashaf Junaid⁴, Maryam Shabbir⁵, Asim Ali¹

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 381-405, 2025, DOI:10.32604/cmc.2025.062452 - 26 March 2025

Abstract Image processing plays a vital role in various fields such as autonomous systems, healthcare, and cataloging, especially when integrated with deep learning (DL). It is crucial in medical diagnostics, including the early detection of diseases like chronic obstructive pulmonary disease (COPD), which claimed 3.2 million lives in 2015. COPD, a life-threatening condition often caused by prolonged exposure to lung irritants and smoking, progresses through stages. Early diagnosis through image processing can significantly improve survival rates. COPD encompasses chronic bronchitis (CB) and emphysema; CB particularly increases in smokers and generally affects individuals between 50 and 70… More >

Saad Awadh Alanazi^*

CMC-Computers, Materials & Continua, Vol.72, No.1, pp. 37-55, 2022, DOI:10.32604/cmc.2022.020118 - 24 February 2022

Abstract Melanoma, also called malignant melanoma, is a form of skin cancer triggered by an abnormal proliferation of the pigment-producing cells, which give the skin its color. Melanoma is one of the skin diseases, which is exceptionally and globally dangerous, Skin lesions are considered to be a serious disease. Dermoscopy-based early recognition and detection procedure is fundamental for melanoma treatment. Early detection of melanoma using dermoscopy images improves survival rates significantly. At the same time, well-experienced dermatologists dominate the precision of diagnosis. However, precise melanoma recognition is incredibly hard due to several factors: low contrast between… More >

LING GONG¹, HUAJUN YANG¹, YING HUANG², ZHU LI¹, JIN NIE³, MENG YE⁴, PENG XIE⁵, DAISHUN LIU^2,*

BIOCELL, Vol.46, No.4, pp. 1025-1032, 2022, DOI:10.32604/biocell.2022.018248 - 15 December 2021

Abstract Respiratory syncytial virus (RSV) infection is known as a risk factor for chronic obstructive pulmonary disease (COPD). RSV infection induces the upregulation of Toll-like receptor 3 (TLR3). This study aimed to investigate the association of TLR3 with RSV induced acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Serum/sputum samples from AECOPD patients, stable chronic obstructive pulmonary disease (SCOPD) patients, and healthy controls were collected. Nested PCR was used to detect RSV. The lung function parameters were assessed by blood gas and lung function analysis. The expression levels of inflammatory factors in sputum and serum samples… More >