EFFAT ALEMZADEH¹, LEILA ALLAHQOLI², AFROOZ MAZIDIMORADI³, ESMAT ALEMZADEH^1,4, FAHIMEH GHASEMI^4,5, HAMID SALEHINIYA⁶, IBRAHIM ALKATOUT^7,*

Oncology Research, Vol.32, No.5, pp. 831-847, 2024, DOI:10.32604/or.2024.031006

Abstract Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for maintenance therapy. However, resistance to these new drugs has emerged. Therefore, understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective… More >

Yanzhong Sun¹, Xiaoni Du^1,*, Shufen Niu², Xiaodong Yang²

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3287-3310, 2024, DOI:10.32604/cmes.2023.043589

Abstract Traditional email systems can only achieve one-way communication, which means only the receiver is allowed to search for emails on the email server. In this paper, we propose a blockchain-based certificateless bidirectional authenticated searchable encryption model for a cloud email system named certificateless authenticated bidirectional searchable encryption (CL-BSE) by combining the storage function of cloud server with the communication function of email server. In the new model, not only can the data receiver search for the relevant content by generating its own trapdoor, but the data owner also can retrieve the content in the same way. Meanwhile, there are dual… More >

Sunil Kumar¹, Dilip Kumar¹, Ramraj Dangi², Gaurav Choudhary³, Nicola Dragoni⁴, Ilsun You^5,*

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 31-63, 2024, DOI:10.32604/cmc.2023.047084

Abstract The widespread and growing interest in the Internet of Things (IoT) may be attributed to its usefulness in many different fields. Physical settings are probed for data, which is then transferred via linked networks. There are several hurdles to overcome when putting IoT into practice, from managing server infrastructure to coordinating the use of tiny sensors. When it comes to deploying IoT, everyone agrees that security is the biggest issue. This is due to the fact that a large number of IoT devices exist in the physical world and that many of them have constrained resources such as electricity, memory,… More >

Mohammad Mazyad Hazzazi¹, Muhammad Sajjad², Zaid Bassfar³, Tariq Shah^2,*, Ashwag Albakri⁴

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3659-3675, 2023, DOI:10.32604/cmc.2023.039013

Abstract In block ciphers, the nonlinear components, also known as substitution boxes (S-boxes), are used with the purpose to induce confusion in cryptosystems. For the last decade, most of the work on designing S-boxes over the points of elliptic curves, chaotic maps, and Gaussian integers has been published. The main purpose of these studies is to hide data and improve the security levels of crypto algorithms. In this work, we design pair of nonlinear components of a block cipher over the residue class of Eisenstein integers (EI). The fascinating features of this structure provide S-boxes pair at a time by fixing… More >

Abid Mahboob¹, Muhammad Asif², Rana Muhammad Zulqarnain^3,*, Imran Saddique⁴, Hijaz Ahmad⁵, Sameh Askar⁶

CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 2565-2578, 2023, DOI:10.32604/cmc.2023.040371

Abstract Nowadays, one of the most important difficulties is the protection and privacy of confidential data. To address these problems, numerous organizations rely on the use of cryptographic techniques to secure data from illegal activities and assaults. Modern cryptographic ciphers use the non-linear component of block cipher to ensure the robust encryption process and lawful decoding of plain data during the decryption phase. For the designing of a secure substitution box (S-box), non-linearity (NL) which is an algebraic property of the S-box has great importance. Consequently, the main focus of cryptographers is to achieve the S-box with a high value of… More >

Osama S. Younes^1,2,*, Abdulmohsen Alharbi¹, Ali Yasseen¹, Faisal Alshareef¹, Faisal Albalawi¹, Umar A. Albalawi^1,3

Computer Systems Science and Engineering, Vol.47, No.3, pp. 2895-2920, 2023, DOI:10.32604/csse.2023.040162

Abstract Due to their significant correlation and redundancy, conventional block cipher cryptosystems are not efficient in encrypting multimedia data. Stream ciphers based on Cellular Automata (CA) can provide a more effective solution. The CA have recently gained recognition as a robust cryptographic primitive, being used as pseudorandom number generators in hash functions, block ciphers and stream ciphers. CA have the ability to perform parallel transformations, resulting in high throughput performance. Additionally, they exhibit a natural tendency to resist fault attacks. Few stream cipher schemes based on CA have been proposed in the literature. Though, their encryption/decryption throughput is relatively low, which… More >

Yi-Li Huang¹, Fang-Yie Leu^1,2,*, Ruey-Kai Sheu¹, Jung-Chun Liu¹, Chi-Jan Huang^2,3

CMC-Computers, Materials & Continua, Vol.77, No.1, pp. 1143-1164, 2023, DOI:10.32604/cmc.2023.037161

Abstract Currently, data security mainly relies on password (PW) or system channel key (SK_CH) to encrypt data before they are sent, no matter whether in broadband networks, the 5th generation (5G) mobile communications, satellite communications, and so on. In these environments, a fixed password or channel key (e.g., PW/SK_CH) is often adopted to encrypt different data, resulting in security risks since this PW/SK_CH may be solved after hackers collect a huge amount of encrypted data. Actually, the most popularly used security mechanism Advanced Encryption Standard (AES) has its own problems, e.g., several rounds have been solved. On the other hand, if… More >

Mingxing Zhou^1,2, Peng Xiao³, Qixu Wang^1,2,*, Shuhua Ruan^1,2, Xingshu Chen^1,2, Menglong Yang⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 957-979, 2024, DOI:10.32604/cmes.2023.028612

Abstract Due to the need for massive device connectivity, low communication latency, and various customizations in 6G architecture, a distributed cloud deployment approach will be more relevant to the space-air-ground-sea integrated network scenario. However, the openness and heterogeneity of the 6G network cause the problems of network security. To improve the trustworthiness of 6G networks, we propose a trusted computing-based approach for establishing trust relationships in multi-cloud scenarios. The proposed method shows the relationship of trust based on dual-level verification. It separates the trustworthy states of multiple complex cloud units in 6G architecture into the state within and between cloud units.… More >

MUNEEBA MALIK¹, MAMOONA MAQBOOL², TOOBA NISAR³, TAZEEM AKHTER⁴, JAVED AHMED UJAN^5,6, ALANOOD S. ALGARNI⁷, FAKHRIA A. AL JOUFI⁸, SULTAN SHAFI K. ALANAZI⁹, MOHAMMAD HADI ALMOTARED¹⁰, MOUNIR M. SALEM BEKHIT¹¹, MUHAMMAD JAMIL^12,*

Oncology Research, Vol.31, No.6, pp. 899-916, 2023, DOI:10.32604/or.2023.030760

Abstract The low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer greater insight into drug resistance. To this end, a series of in silico and in vitro experiments were conducted to identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes involved in cisplatin resistance across KIRC were retrieved from the National Center for Biotechnology Information (NCBI) database using search terms as “Kidney renal clear cell carcinoma” and “Cisplatin resistance”. The genes retrieved were analyzed… More >

Mohammad Mazyad Hazzazi¹, Hafeez Ur Rehman^2,*, Tariq Shah², Hajra Younas²

CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 2033-2060, 2023, DOI:10.32604/cmc.2023.040629

Abstract Protecting the integrity and secrecy of digital data transmitted through the internet is a growing problem. In this paper, we introduce an asymmetric key algorithm for specifically processing images with larger bit values. To overcome the separate flaws of elliptic curve cryptography (ECC) and the Hill cipher (HC), we present an approach to picture encryption by combining these two encryption approaches. In addition, to strengthen our scheme, the group laws are defined over the rational points of a given elliptic curve (EC) over a Galois field (GF). The exclusive-or (XOR) function is used instead of matrix multiplication to encrypt and… More >