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    MafF Is Regulated via the circ-ITCH/miR-224-5p Axis and Acts as a Tumor Suppressor in Hepatocellular Carcinoma

    Minhua Wu*1, Xubin Deng†1, Yu Zhong‡1, Li Hu*, Xiujuan Zhang§, Yanqin Liang*, Xiaofang Li, Xiaoxia Ye*

    Oncology Research, Vol.28, No.3, pp. 299-309, 2020, DOI:10.3727/096504020X15796890809840

    Abstract MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. But the expression and function of MafF in hepatocellular carcinoma (HCC) remain unclear. In this study, we investigated the relationship between endogenous MafF expression and HCC progression and explored the regulatory mechanism of MafF expression in HCC. We found that MafF decreased in HCC tissues and cells. Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation and induced cell apoptosis. Bioinformatics analysis and luciferase assay identified MafF as a direct target of miR-224-5p. RNA pull-down assay More >

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