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Search Results (16)
  • Open Access


    Long-Term Outcomes of Systemic-to-Pulmonary Artery Shunt in Patients with Functional Single Ventricle and Heterotaxy Syndrome

    Shota Kawai1, Takashi Kido1,*, Yuta Teguri1, Koji Miwa1, Tomomitsu Kanaya1, Yoichiro Ishii2, Hisaaki Aoki2, Futoshi Kayatani2, Sanae Tsumura1

    Congenital Heart Disease, Vol.18, No.4, pp. 399-411, 2023, DOI:10.32604/chd.2023.042243

    Abstract Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-to-pulmonary artery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed all patients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January 2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiring early modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonary blood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank: p = 0.04), but the statistical significance… More >

  • Open Access


    Exercise Catheterization for Hemodynamic Evaluation of Adults with Coarctation of the Aorta

    Irene Martin de Miguel1, C. Charles Jain1, Alexander C. Egbe1, Jason H. Anderson2, Heidi M. Connolly1, William R. Miranda1,*

    Congenital Heart Disease, Vol.17, No.6, pp. 605-615, 2022, DOI:10.32604/chd.2022.023969

    Abstract Background: Coarctation of the aorta (CoA) is associated with a generalized arteriopathy and long-term complications despite repair. Data on invasive exercise hemodynamics in this population are lacking. Accordingly, we reviewed adults with CoA undergoing exercise catheterization to assess 1. hemodynamic profile; 2. feasibility for assessment of CoA severity. Methods: Twenty patients undergoing exercise cardiac catheterization (12 arm adduction and 8 supine cycle ergometry) at a quaternary care center between 2004 and 2021 were identified. Resting and exercise hemodynamic data were abstracted from the procedure logs. Results: Mean age was 43.6 ± 12.0 years. Eleven patients (55%) had resting pulmonary arterial wedge pressure… More >

  • Open Access


    Predictors and Effects of Persistent Hypertension after Successful Treatment of Coarctation of the Aorta

    Mohamed Saber Hafez*, Alaa Roushdy, Dina Ezzeldin

    Congenital Heart Disease, Vol.17, No.3, pp. 325-333, 2022, DOI:10.32604/chd.2022.019025

    Abstract Background: Coarctation of the aorta is a congenital heart disease that sometimes remains clinically silent until adulthood, usually presenting with arterial hypertension. It is well known that after coarctation treatment, many patients remain hypertensive despite successful repair. In this study we approached the predictors and effects of residual hypertension after successful coarctation therapy. Methods: It was a cross sectional observational study involving 50 patients who underwent Coarctation repair/angioplasty in Ain Shams university hospitals. We divided the patients into two groups (hypertensive and normotensive) and we studied their demographic data (e.g., age, gender, age at first repair, follow up period, etc.)… More >

  • Open Access


    The Impact of a Bicuspid Aortic Valve on Aortic Geometry and Function in Patients with Aortic Coarctation: A Comprehensive CMR Study

    Laura Schweikert1, Dominik Gabbert1, Sylvia Krupickova2, Inga Voges1,*

    Congenital Heart Disease, Vol.16, No.6, pp. 551-560, 2021, DOI:10.32604/CHD.2021.016635

    Abstract Background: An isolated bicuspid aortic valve (BAV) is associated with structural and functional abnormalities of the aorta and the left ventricle (LV). Although ~50% of patients with aortic coarctation (CoA) have a BAV, less is known about its impact on LV function and aortic geometry and function in CoA patients. In this cardiovascular magnetic resonance imaging (CMR) study, we analysed markers of LV and aortic function as well as aortic geometry in a large cohort of CoA patients with a BAV and compared them with CoA patients with a tricuspid aortic valve (TAV). Methods: We included 48 patients with a… More >

  • Open Access


    When the Blood Pressure Misleads You: A Diagnostic Conundrum in an Unusual Case of Coarctation

    Eva Kapravelou1, Hugo Issa2, Gordon Culham3, Martin Hosking1, Sanjiv K. Gandhi2, Shubhayan Sanatani1,*

    Congenital Heart Disease, Vol.16, No.6, pp. 675-680, 2021, DOI:10.32604/CHD.2021.016548

    Abstract A 4-month-old previously healthy baby was found to be in congestive heart failure with LV dysfunction and a right aortic arch with severe coarctation, undetectable by blood pressure measurements. A cardiac CT and central blood pressure led to the diagnosis of a unique anatomic variant of aortic coarctation. Once diagnosed the patient underwent surgery with an uncomplicated recovery. More >

  • Open Access


    Surgical Versus Percutaneous Stenting Treatment of Isolated Aortic Coarctation: Long-Term Follow-Up

    Marie Laure Yammine#,*, Camilla Calvieri#, Marcello Chinali, Salvatore Giannico, Giulia Cafiero, Ugo Giordano

    Congenital Heart Disease, Vol.16, No.5, pp. 457-467, 2021, DOI:10.32604/CHD.2021.015896

    Abstract Background: In recent decades, aortic stenting has become a promising alternative to surgery for both native aortic coarctation and re-stenosis in children and adults. However, comparative long-term outcomes have poorly been investigated. Methods: We included 212 patients with previous aortic repair (19 ± 8.7 years) divided into 3 groups: 139 with single-time surgical repair (CoA-S group); 18 with single-time percutaneous stenting (CoA-PS group); and 55 hybrid patients with multiple aortic procedures because of re-coarctation occurrence (CoA-H group). All patients underwent 24-hour ambulatory blood pressure monitoring and trans-thoracic echocardiography. Results: After a median follow-up of 17 years after aortic repair, antihypertensive… More >

  • Open Access


    Screening Coarctation of Aorta with Clinical and Echocardiographic Profiles in Infants: A Pilot Study

    Ruikun Zou1, Yifei Wang1,*, Chengcheng Pang2, Yunxia Sun1, Chen Chen1, Jian Zhuang3

    Congenital Heart Disease, Vol.16, No.2, pp. 159-170, 2021, DOI:10.32604/CHD.2021.015050

    Abstract Aim: To determine the profiles of clinical features including four-limb blood pressure (BP), saturations of peripheral oxygen (SpO2), and echocardiographic features in infants with coarctation of aorta (CoA) to facilitate congenital heart diseases screening. Methods: The charts of infants with CoA were retrospectively reviewed. All in-hospital infants suspected of congenital heart diseases by clinical teams were prospectively measured of four limbs BPs and SpO2 in a regional cardiac transferring center during 2013 and 2019. Echocardiography as a gold standard test was followed within 2 days after suspicion. All infants were divided into non-significant CoA group or significant CoA group based… More >

  • Open Access


    Important Newborn Cardiac Diagnostic Dilemmas for the Neonatologist and Cardiologist–A Clinical Perspective

    Samuel Menahem1,2,*, Arvind Sehgal3,4

    Congenital Heart Disease, Vol.16, No.2, pp. 189-196, 2021, DOI:10.32604/CHD.2021.014903

    Abstract Most congenital heart disease (CHD) is readily recognisable in the newborn. Forewarned by previous fetal scanning, the presence of a murmur, tachypnoea, cyanosis and/or differential pulses and saturations all point to a cardiac abnormality. Yet serious heart disease may be missed on a fetal scan. There may be no murmur or clinical cyanosis, and tachypneoa may be attributed to non-cardiac causes. Tachypnoea on day 1 is usually non-cardiac except arising from ventricular failure or a large systemic arteriovenous fistula. A patent ductus arteriosus (PDA) may support either pulmonary or systemic duct dependent circulations. The initially high pulmonary vascular resistance (PVR)… More >

  • Open Access


    Cardiovascular risk factors in adults with coarctation of the aorta

    Maria Fedchenko, Zacharias Mandalenakis, Helena Dellborg, Görel Hultsberg‐Olsson, Anna Björk, Peter Eriksson, Mikael Dellborg

    Congenital Heart Disease, Vol.14, No.4, pp. 549-558, 2019, DOI:10.1111/chd.12785

    Abstract Background: The aging patient with adult congenital heart disease (ACHD) faces the risk of developing atherosclerotic disease. Patients with coarctation of the aorta (CoA) are especially vulnerable because of an inherent high risk of developing hy‐ pertension. However, data on the prevalence of other cardiovascular risk factors are scarce. Therefore, this study aimed to describe the prevalence of traditional cardio‐ vascular risk factors (diabetes, hypertension, hyperlipidemia, smoking, obesity, and sedentary lifestyle) in adult patients with CoA.
    Methods: Patients with CoA who were registered at the ACHD clinic in Gothenburg were asked to participate in a comprehensive cardiovascular risk assessment. This… More >

  • Open Access


    Long-term outcomes after aortic coarctation repair in Maltese patients: A population-based study

    Maryanne Caruana1, Victor Grech2

    Congenital Heart Disease, Vol.12, No.5, pp. 588-595, 2017, DOI: 10.1111/chd.12488

    Abstract Objectives: To investigate survival and freedom from reintervention after aortic coarctation repair in Maltese patients and to compare cardiovascular mortality in coarctation repair survivors with that in the general population.
    Design: All 72 aortic coarctation patients with any type of repair, born by end-1997 and logged in the local database were included. Trends in timing and type of repair were determined by comparing patients born before and after 1985. Kaplan-Meier analyses of survival and reintervention-free survival were performed on the 59 repair survivors with complete follow-up data (mean follow-up 26.13 ± 9.62 (range 1.05–44.55 years). Cardiovascular mortality in repair survivors… More >

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