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  • Open Access

    ARTICLE

    Landscape of Sequence Variations in Homologous Copies of FAD2 and FAD3 in Rapeseed (Brassica napus L.) Germplasm with High/Low Linolenic Acid Trait

    Haoxue Wu#, Xiaohan Zhang§,#, Xiaoyu Chen, Kang Li, Aixia Xu, Zhen Huang, Jungang Dong, Chengyu Yu*

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 627-640, 2024, DOI:10.32604/phyton.2024.050321

    Abstract Genetic manipulation (either restraint or enhancement) of the biosynthesis pathway of α-linolenic acid (ALA) in seed oil is an important goal in Brassica napus breeding. B. napus is a tetraploid plant whose genome often harbors four and six homologous copies, respectively, of the two fatty acid desaturases FAD2 and FAD3, which control the last two steps of ALA biosynthesis during seed oil accumulation. In this study, we compared their promoters, coding sequences, and expression levels in three high-ALA inbred lines 2006L, R8Q10, and YH25005, a low-ALA line A28, a low-ALA/high-oleic-acid accession SW, and the wildtype ZS11. The expression levels of… More >

  • Open Access

    ARTICLE

    Intrusion Detection Model Using Chaotic MAP for Network Coding Enabled Mobile Small Cells

    Chanumolu Kiran Kumar, Nandhakumar Ramachandran*

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3151-3176, 2024, DOI:10.32604/cmc.2023.043534

    Abstract Wireless Network security management is difficult because of the ever-increasing number of wireless network malfunctions, vulnerabilities, and assaults. Complex security systems, such as Intrusion Detection Systems (IDS), are essential due to the limitations of simpler security measures, such as cryptography and firewalls. Due to their compact nature and low energy reserves, wireless networks present a significant challenge for security procedures. The features of small cells can cause threats to the network. Network Coding (NC) enabled small cells are vulnerable to various types of attacks. Avoiding attacks and performing secure “peer” to “peer” data transmission is a challenging task in small… More >

  • Open Access

    ARTICLE

    Role of oncogenic long noncoding RNA KCNQ1OT1 in colon cancer

    GANG LIU1,#, LEI SHI1,#, BIN WANG1, ZEHUI WU1, HAIYUAN ZHAO1, TIANYU ZHAO2, LIANGHUI SHI1,*

    Oncology Research, Vol.32, No.3, pp. 585-596, 2024, DOI:10.32604/or.2023.029349

    Abstract The role of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) in colon cancer involves various tumorigenic processes and has been studied widely. However, the mechanism by which it promotes colon cancer remains unclear. Retroviral vector pSEB61 was retrofitted in established HCT116-siKCN and SW480-siKCN cells to silence KCNQ1OT1. Cellular proliferation was measured using CCK8 assay, and flow cytometry (FCM) detected cell cycle changes. RNA sequencing (RNA-Seq) analysis showed differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out to analyze enriched functions and signaling pathways. RT-qPCR, immunofluorescence, and western blotting… More >

  • Open Access

    ARTICLE

    A Video Captioning Method by Semantic Topic-Guided Generation

    Ou Ye, Xinli Wei, Zhenhua Yu*, Yan Fu, Ying Yang

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1071-1093, 2024, DOI:10.32604/cmc.2023.046418

    Abstract In the video captioning methods based on an encoder-decoder, limited visual features are extracted by an encoder, and a natural sentence of the video content is generated using a decoder. However, this kind of method is dependent on a single video input source and few visual labels, and there is a problem with semantic alignment between video contents and generated natural sentences, which are not suitable for accurately comprehending and describing the video contents. To address this issue, this paper proposes a video captioning method by semantic topic-guided generation. First, a 3D convolutional neural network is utilized to extract the… More >

  • Open Access

    ARTICLE

    An Encode-and CRT-Based Scalability Scheme for Optimizing Transmission in Blockchain

    Qianqi Sun, Fenhua Bai*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1733-1754, 2024, DOI:10.32604/cmes.2023.044558

    Abstract Blockchain technology has witnessed a burgeoning integration into diverse realms of economic and societal development. Nevertheless, scalability challenges, characterized by diminished broadcast efficiency, heightened communication overhead, and escalated storage costs, have significantly constrained the broad-scale application of blockchain. This paper introduces a novel Encode-and CRT-based Scalability Scheme (ECSS), meticulously refined to enhance both block broadcasting and storage. Primarily, ECSS categorizes nodes into distinct domains, thereby reducing the network diameter and augmenting transmission efficiency. Secondly, ECSS streamlines block transmission through a compact block protocol and robust RS coding, which not only reduces the size of broadcasted blocks but also ensures transmission… More >

  • Open Access

    ARTICLE

    Long non-coding RNA DPP10-AS1 represses the proliferation and invasiveness of glioblastoma by regulating miR-24-3p/CHD5 signaling pathway

    JIWEI SUN1,2,#, LIANG XU1,#, YESEN ZHANG2, HAORAN LI1, JIE FENG2, XUEFENG LU2, JUN DONG1,*

    BIOCELL, Vol.47, No.12, pp. 2721-2733, 2023, DOI:10.32604/biocell.2023.043869

    Abstract Objective: This investigation aimed to unveil new prospective diagnosis-related biomarkers together with treatment targets against glioblastoma. Methods: The expression levels of long non-coding RNA (lncRNA) DPP10-AS1 were assessed using real-time quantitative polymerase chain reaction (RT-qPCR) within both the patient tissue specimens and glioblastoma cell lines. The relationship between lncRNA DPP10-AS1 expression in glioblastoma and patient prognosis was investigated. Cell Counting Kit-8 (CCK-8), transwell, and clonogenic experiments were utilized to assess tumor cells’ proliferation, invasiveness, and migratory potentials after lncRNA DPP10-AS1 expression was up or down-regulated. Using an online bioinformatics prediction tool, the intracellular localization of lncRNA DPP10-AS1 and its target… More >

  • Open Access

    ARTICLE

    A Lightweight Road Scene Semantic Segmentation Algorithm

    Jiansheng Peng1,2,*, Qing Yang1, Yaru Hou1

    CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 1929-1948, 2023, DOI:10.32604/cmc.2023.043524

    Abstract In recent years, with the continuous deepening of smart city construction, there have been significant changes and improvements in the field of intelligent transportation. The semantic segmentation of road scenes has important practical significance in the fields of automatic driving, transportation planning, and intelligent transportation systems. However, the current mainstream lightweight semantic segmentation models in road scene segmentation face problems such as poor segmentation performance of small targets and insufficient refinement of segmentation edges. Therefore, this article proposes a lightweight semantic segmentation model based on the LiteSeg model improvement to address these issues. The model uses the lightweight backbone network… More >

  • Open Access

    ARTICLE

    Diagnostic and classification value of immune-related lncRNAs in dilated cardiomyopathy

    CONGCHEN BAI1, QIHANG KONG2, HAO TANG2, SHUWEN ZHANG2, JUNTENG ZHOU3,*, XIAOJING LIU2,4,*

    BIOCELL, Vol.47, No.11, pp. 2517-2533, 2023, DOI:10.32604/biocell.2023.043864

    Abstract Background: Various physiological mechanisms are linked to dilated cardiomyopathy (DCM) development, including oxidative stress, immune irregularities, inflammation, fibrosis, and genetic changes. However, precise molecular drivers of DCM, especially regarding abnormal immune responses, remain unclear. This study investigates immune-related long non-coding RNAs (lncRNAs) in DCM’s diagnostic and therapeutic potential. Methods: GSE141910, GSE135055, and GSE165303 datasets were acquired from the GEO database. LASSO, SVM-RFE, and random forest algorithms identified DCM-associated immune-related lncRNAs. Diagnostic capabilities were assessed by Nomogram and receiver operating characteristic (ROC) curves. Multivariate linear regression explored lncRNA correlations with ejection fraction. Single-sample gene set enrichment analysis (ssGSEA) gauged immune cell… More > Graphic Abstract

    Diagnostic and classification value of immune-related lncRNAs in dilated cardiomyopathy

  • Open Access

    ARTICLE

    Long non-coding RNA-ATB induces trastuzumab resistance and aggravates the progression of gastric cancer by repressing miR- 200c via ZNF217 elevation

    JIAZHUANG LI*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU

    BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860

    Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell functions and trastuzumab resistance of… More >

  • Open Access

    ARTICLE

    Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis

    ARCHITTAPON NOKKEAW1,2,3,#, PANNATHON THAMJAMRASSRI1,2,3,#, NAPHAT CHANTARAVISOOT1,4, PISIT TANGKIJVANICH1,2,*, CHAIYABOOT ARIYACHET1,2,*

    Oncology Research, Vol.31, No.6, pp. 989-1005, 2023, DOI:10.32604/or.2023.030395

    Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer death worldwide; nevertheless, current therapeutic options are limited or ineffective for many patients. Therefore, elucidation of molecular mechanisms in HCC biology could yield important insights for the intervention of novel therapies. Recently, various studies have reported dysregulation of long non-coding RNAs (lncRNAs) in the initiation and progression of HCC, including H19; however, the biological function of H19 in HCC remains unclear. Here, we show that knockdown of H19 disrupted HCC cell growth, impaired the G1-to-S phase transition, and promoted apoptosis, while overexpression of H19 yielded the opposite results. Screening for expression… More > Graphic Abstract

    Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis

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