Deborah Joyce1, Wan Muhammad Farhan Syafiq Wan Mohd Nor2, Ivy Chung2, Amira Hajirah Abd Jamil1, Nur Akmarina Mohd Said1,*
BIOCELL, Vol.50, No.8, 2026, DOI:10.32604/biocell.2026.077378
- 27 July 2026
Abstract Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various aspects of cancer cell behaviour, including metabolic reprogramming, proliferation, migration, and intercellular communication. Concurrently, dysregulated cholesterol metabolism has emerged as a hallmark of cancer, influencing tumour growth, immune evasion, chemoresistance, and metastasis. While numerous studies have explored the role of ncRNAs like long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in modulating cholesterol metabolism within either cancer cells or immune cells, the mechanism of their action largely depends on the involvement of microRNAs (miRNAs). However, the… More >