Cheng-Hsun Chuang^1,2,3,#, Ping-Kun Tsai^3,4,5,6,#, Shih-Wen Kao^7,8, Yu-Hsun Wang^8,9,*, Chao-Bin Yeh^1,2,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072875 - 30 December 2025

Abstract Background: To determine whether initiating a glucagon-like peptide-1 receptor agonist (GLP-1 RA) within 3 months of type 2 diabetes (T2DM) diagnosis alters the subsequent risk of overall and site-specific cancer and whether this association differs by baseline body-mass index (BMI). Methods: This retrospective cohort study used electronic health records from the TriNetX U.S. research network. Adults aged 20 years or older diagnosed with T2DM between 2016 and 2024 were included if they received any hypoglycemic agents within 3 months before and after diagnosis. Following 1:1 propensity score matching, both the GLP-1 RA user and non-user… More > Graphic Abstract

Shun Maki^1,*, Satoshi Nakano¹, Taiki Haga², Takehiro Niitsu¹, Ikuya Ueta¹

Congenital Heart Disease, Vol.20, No.5, pp. 547-558, 2025, DOI:10.32604/chd.2025.072277 - 30 November 2025

Abstract Background: Considering the limited evidence for acute postoperative nutritional therapy for congenital heart disease (CHD), this study evaluated the effects of achieving enteral nutrition (EN) targets in the acute postoperative phase on clinical outcomes in infants after congenital heart surgery. Methods: This retrospective cohort study, conducted in a multivalent pediatric intensive care unit (PICU), enrolled infants aged ≤6 months following congenital heart surgery between April 2021 and March 2023. Based on the American Society for Parenteral and Enteral Nutrition guidelines, the EN target was defined as two-thirds of the resting energy expenditure with a protein intake… More >

Hande İştar^1,#,*, Buğra Harmandar¹, Melike Korkmaz Toker², Fulden Cantaş Türkiş³

Congenital Heart Disease, Vol.20, No.4, pp. 503-517, 2025, DOI:10.32604/chd.2025.068540 - 18 September 2025

Abstract Background: The neutrophil–lymphocyte ratio (NLR) is a simple, cost-effective marker of systemic inflammation. This study aims to evaluate the association between perioperative NLR and postoperative outcomes in pediatric patients undergoing congenital heart surgery with cardiopulmonary bypass (CPB). Methods: We retrospectively reviewed 70 patients under 18 years of age who underwent surgery between 2018 and 2023. NLR was measured preoperatively and on postoperative days (POD) 0, 1, 2, 3, and 6. Receiver operating characteristic analysis identified optimal cutoffs, and associations with postoperative outcomes were assessed. Results: The preoperative NLR cutoff of 1.14 (AUC = 0.75) was associated with More >

Hui Yi^1,2,#, Hongjian Shi^2,3,#, Fuquan Kan^2,4,#, Fan Han², Lei Wan⁵, Xiaoyang Hong¹, Zhe Zhao¹, Junjie Shao², Gang Wang¹, Hui Wang¹, Hua Yan⁵, Xiujuan Shi¹, Ran Zhang^2,6,*, Gengxu Zhou^1,*

Congenital Heart Disease, Vol.20, No.4, pp. 519-530, 2025, DOI:10.32604/chd.2025.067164 - 18 September 2025

Abstract Background: To investigate the impact of preoperative extracorporeal membrane oxygenation (ECMO) on clinical outcomes in pediatric heart transplantation (PHT). Methods: This retrospective cohort analysis was conducted on 19 pediatric heart transplant recipients, divided into two groups: ECMO and non-ECMO, based on whether preoperative ECMO was utilized. We evaluated the patients’ surgical conditions, postoperative complications, and survival rates. Additionally, the analysis focused on the differences and correlations in clinical characteristics, inflammatory markers, and long-term survival outcomes. Results: There was no statistically significant difference in perioperative survival rates between the ECMO group (85.7%) and the non-ECMO group (83.3%). However,… More >

Jing Ling¹, Naijimuding Abudurexiti¹, Jiaxiong Wu¹, Runzhang Liang¹, Zirui Peng¹, Yuting Huang², Haiyun Yuan^1,3,4,*, Shusheng Wen^1,3,4,*

Congenital Heart Disease, Vol.20, No.1, pp. 13-25, 2025, DOI:10.32604/chd.2025.063437 - 18 March 2025

Abstract Background: Although Cone reconstruction has been shown to improve biventricular function over time, postoperative right ventricular dysfunction (RVD) is frequently observed, signiffcantly affecting reoperation and long-term prognosis. This study aims to identify the predictors for postoperative RVD. Methods: This retrospective cohort study included 51 patients with Ebstein’s anomaly who underwent the Cone reconstruction. RVD was deffned as right ventricular fractional area change (RV-FAC) less than 35% and tricuspid annular plane systolic excursion (TAPSE) less than 17 mm through pre-discharge echocardiography. Univariate and multivariate analyses were used to analyze the pre-operative predictors. Results: The median age at surgery… More >

Ibrahim M. Gosadi^*

International Journal of Mental Health Promotion, Vol.27, No.1, pp. 41-49, 2025, DOI:10.32604/ijmhp.2024.059822 - 31 January 2025

Abstract Objective: There is conflicting evidence suggesting an association between Ramadan and mental health. Aim: This study aims to assess changes in depression, anxiety, and stress levels during Ramadan among university students from Saudi Arabia and to measure the magnitude of change in these levels according to gender. Methods: This study is a prospective cohort study. Data was collected using a structured questionnaire that measured demographic data of the students, and levels of depression, anxiety, and stress utilizing the short form of the Depression Anxiety Stress Scales questionnaire (DASS 21). The assessments were performed starting from the… More >

Laortip Rattanapittayaporn, Maliwan Oofuvong^*, Jutarat Tanasansuttiporn, Thavat Chanchayanon

Congenital Heart Disease, Vol.18, No.1, pp. 23-39, 2023, DOI:10.32604/chd.2023.026026 - 09 January 2023

Abstract Background: Prolonged preoperative fasting can cause hypoglycemia, hyperglycemia, and intravascular volume depletion in children. We aimed to examine whether prolonged preoperative fasting is associated with in-hospital mortality and other morbidities in pediatric cardiothoracic surgery. Methods: This retrospective cohort study included children aged 0–3 years who underwent cardiac surgery between July 2014 and October 2020. The patient demographic data, surgery-related and anesthesia-related factors, and postoperative outcomes, including hypoglycemia, hyperglycemia, sepsis, length of intensive care unit stay, and in-hospital mortality, were recorded. The main exposure and outcome variables were prolonged fasting and time-to-death after surgery, respectively. The associations between… More > Graphic Abstract

Yang Wang¹, Jinlong Lin^1,*, M. James C. Crabbe^2,3,4, Xiao-Guang Yue⁵

International Journal of Mental Health Promotion, Vol.24, No.3, pp. 385-398, 2022, DOI:10.32604/ijmhp.2022.020664 - 17 March 2022

Abstract Health status is widely regarded as a correlate of depressive symptoms. However, health assessments based on clinical diagnosis in rural areas with poor medical conditions are very limited. Self-rated health (SRH) serves as a simple and convenient evaluation indicator, which may be used as an independent predictor of depressive symptoms. To confirm the relationship between SRH and depressive symptoms in rural adults, a longitudinal survey of rural households in China was conducted using the China Family Panel Studies (CFPS) from 2012 to 2016. Propensity score matching and logistic regression analysis were used to explore the… More >

Zhiyi Peng^*1, Guohong Cao^†1, Qinming Hou^‡, Ling Li^§, Shihong Ying^*, Junhui Sun^¶, Guanhui Zhou^¶, Jian Zhou^#, Xin Zhang^*, Wenbin Ji^**, Zhihai Yu^††, Tiefeng Li^‡‡, Dedong Zhu^§, Wenhao Hu^§§, Jiansong Ji^¶¶, Haijun Du^##, Changsheng Shi^***, Xiaohua Guo^†††, Jian Fang^‡‡‡, Jun Han^§§§, Wenjiang Gu^¶¶¶, Xiaoxi Xie^###, Zhichao Sun^****, Huanhai Xu^††††, Xia Wu^‡‡‡‡, Tingyang Hu^§§§§, Jing Huang^¶¶¶¶, Hongjie Hu^‡‡‡‡, Jiaping Zheng^####, Jun Luo^####, Yutang Chen^####, Wenqiang Yu^§§§§, Guoliang Shao^####

Oncology Research, Vol.28, No.3, pp. 249-271, 2020, DOI:10.3727/096504019X15766663541105

Abstract This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres^® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR),… More >

Jiachen Li, Xianchao Jiang, Sim-eng Zhang, Jinyang Liu, Yajuan Zhang, Jun Yan, Shoujun Li, Qiang Wang^*

Congenital Heart Disease, Vol.15, No.5, pp. 387-397, 2020, DOI:10.32604/CHD.2020.013127 - 23 September 2020

Abstract Background: Ebstein’s anomaly (EA) is a malformation of the tricuspid valve (TV) and myopathy of the right ventricle (RV). Surgery is now the main treatment for the defect. Objective: To summarize our surgical results and experience based on patients with EA who were under 7 years of age and treated with different surgical treatments. Design: Single-center cohort study of Ebstein’s anomaly. Setting: China. Participants: 80 patients under 7 years old who were diagnosed of EA and underwent different surgical treatments were consecutively enrolled in our research from January 2010 to December 2019. Results: The median age of the… More >