Jing Zeng^*1, Tianping Du^†1, Yafeng Song^‡, Yan Gao^‡, Fuyan Li^‡, Ruimin Wu^‡, Yijia Chen^‡, Wei Li^‡, Hong Zhou^‡, Yi Yang^‡, Zhijun Pei^‡

Oncology Research, Vol.28, No.5, pp. 551-552, 2020, DOI:10.3727/096504020X16032056440085

Abstract Long noncoding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) has been demonstrated to play an important role in diverse tumorigenesis. However, the biological function of lncRNAs in glioma is still unknown. In this study, we found that lncRNA CCAT2 was overexpressed in glioma tissues and cell lines and associated with tumor grade and size. Furthermore, patients with high levels of lncRNA CCAT2 had poorer survival than those with lower levels of lncRNA CCAT2. Knocking down lncRNA CCAT2 expression significantly suppressed the glioma cell growth, migration, and invasion, as well as induced early apoptosis of glioma cells in vitro. Moreover, lncRNA… More >

Fei Han¹, Jianghong Qu², Fengyue Li¹, Dapeng Zhang³, Jiangming Qu⁴, Guanghua Li^5,*

Oncologie, Vol.23, No.1, pp. 131-140, 2021, DOI:10.32604/Oncologie.2021.014153

Abstract Aim: This study aims to explore the role of serum long non-coding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) as a diagnostic marker for gastric cancer (GC). Methods: We recruited 76 patients with GC admitted to our hospital (the observation group, OG) and 83 healthy volunteers undergoing physical examinations during the same period (the control group, CG). CCAT2 expression was tested and its correlation with clinicopathological characteristics of GC was analyzed. We also explored the value of CCAT2 in assessing the treatment efficacy, predicting the fatality, and evaluating the prognosis of patients. Results: We detected higher CCAT2 levels in OG… More >