Lining Arnold Ju^*

Molecular & Cellular Biomechanics, Vol.20, No.2, pp. 95-96, 2023, DOI:10.32604/mcb.2023.042338

Abstract This article has no abstract. More >

Taiji Adachi^1,*, Yoshitaka Kameo¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 88-88, 2019, DOI:10.32604/mcb.2019.07417

Abstract Bone adaptation by remodeling is a process to change its outer shape and internal structure to the changing mechanical environment by osteoclastic bone resorption and osteoblastic bone formation. These cellular activities are regulated by mechanosensory network of osteocytes embedded in bone matrix. An imbalance between bone resorption and formation due to low loadings or disuse results in metabolic bone disorders such as osteoporosis. Many studies have identified various signaling pathways that regulate these cellular activities; however, the physiological and pathological conditions of bone as a system remain difficult to understand because of the complexity of the signaling networks including mechano-biochemical… More >

Karol Miller

The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.4, pp. 188-188, 2019, DOI:10.32604/icces.2019.06116

Abstract The field of Biomechanics is in the most exiting state of transition from the theoretical subject of the 20th century to a practical discipline providing patient-specific solutions in the 21st century. Computational biomechanics is becoming instrumental in enabling a new era of personalized medicine based on patient-specific scientific computations. The Finite Element Method is used by almost all members of computational biomechanics community to analyze mathematical models described by sets of partial differential equations. FEM, however, has a number of fairly serious theoretical and practical deficiencies when applied to highly deformable objects of very complicated shapes, such as human soft… More >

T. Yamaguchi¹, T. Ishikawa², Y. Imai²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.2, pp. 79-80, 2009, DOI:10.3970/icces.2009.009.079

Abstract Human cardiovascular system is always under the integrated nervous and humoral control of the whole body, i.e. in homeostasis. Multiple feedback mechanisms with mutual interactions among systems, organs, and even tissues provide integrated control of the entire body. These control mechanisms have different spatial coverages, from the micro- to macroscale, and different time constants, from nanoseconds to decades. We think that these variations in spatial as well as temporal scales should be taken into account in discussing phenomena in the cardiovascular system.
In this background,we have been investigatingthe cardiovascular system over micro to macro levels by using conjugated computational mechanics… More >

Yoshitaka Shimada^∗,†, Taiji Adachi^∗,†,‡, Yasuhiro Inoue^∗,†, Masaki Hojo^∗

Molecular & Cellular Biomechanics, Vol.6, No.3, pp. 161-174, 2009, DOI:10.3970/mcb.2009.006.161

Abstract The actin filament, which is the most abundant component of the cytoskeleton, plays important roles in fundamental cellular activities such as shape determination, cell motility, and mechanosensing. In each activity, the actin filament dynamically changes its structure by polymerization, depolymerization, and severing. These phenomena occur on the scales ranging from the dynamics of actin molecules to filament structural changes with its deformation due to the various forces, for example, by the membrane and solvent. To better understand the actin filament dynamics, it is important to focus on these scales and develop its mathematical model. Thus, the objectives of this study… More >