Delaram Molkara, Jose A. Silva Sepulveda, Thomas Do, Christopher Davis, Gregory P. Goldstein, John W. Moore, Howaida G El-Said
Congenital Heart Disease, Vol.12, No.3, pp. 270-274, 2017, DOI:10.1111/chd.12432
Abstract Objective: Neonatal coronary thrombosis is a rarely reported disorder, with variable outcomes
described. This study assessed the feasibility and safety of an institutional protocol using tissue
plasminogen activator (tPA) administration for the treatment of neonatal coronary artery thrombi.
Methods: They reviewed the outcome of three neonates with clinical evidence of myocardial
infarction secondary to coronary thrombosis. All three underwent the tPA treatment protocol.
Results: The three described cases presented at 5 hours, 15 hours, and 10 days of life. The
patients identified underwent the tPA protocol at least once. There was clinical evidence of
improvement in coronary flow, as well… More >
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