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  • Open Access

    REVIEW

    Transforming Healthcare with State-of-the-Art Medical-LLMs: A Comprehensive Evaluation of Current Advances Using Benchmarking Framework

    Himadri Nath Saha1, Dipanwita Chakraborty Bhattacharya2,*, Sancharita Dutta3, Arnab Bera3, Srutorshi Basuray4, Satyasaran Changdar5, Saptarshi Banerjee6, Jon Turdiev7

    CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-56, 2026, DOI:10.32604/cmc.2025.070507 - 09 December 2025

    Abstract The emergence of Medical Large Language Models has significantly transformed healthcare. Medical Large Language Models (Med-LLMs) serve as transformative tools that enhance clinical practice through applications in decision support, documentation, and diagnostics. This evaluation examines the performance of leading Med-LLMs, including GPT-4Med, Med-PaLM, MEDITRON, PubMedGPT, and MedAlpaca, across diverse medical datasets. It provides graphical comparisons of their effectiveness in distinct healthcare domains. The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making, documentation, drug discovery, research, patient interaction, and public health. The paper addresses deployment challenges of Medical-LLMs, More >

  • Open Access

    ARTICLE

    Dynamic Knowledge Graph Reasoning Based on Distributed Representation Learning

    Qiuru Fu1, Shumao Zhang1, Shuang Zhou1, Jie Xu1,*, Changming Zhao2, Shanchao Li3, Du Xu1,*

    CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-19, 2026, DOI:10.32604/cmc.2025.070493 - 09 December 2025

    Abstract Knowledge graphs often suffer from sparsity and incompleteness. Knowledge graph reasoning is an effective way to address these issues. Unlike static knowledge graph reasoning, which is invariant over time, dynamic knowledge graph reasoning is more challenging due to its temporal nature. In essence, within each time step in a dynamic knowledge graph, there exists structural dependencies among entities and relations, whereas between adjacent time steps, there exists temporal continuity. Based on these structural and temporal characteristics, we propose a model named “DKGR-DR” to learn distributed representations of entities and relations by combining recurrent neural networks More >

  • Open Access

    ARTICLE

    Recurrent MAPPO for Joint UAV Trajectory and Traffic Offloading in Space-Air-Ground Integrated Networks

    Zheyuan Jia, Fenglin Jin*, Jun Xie, Yuan He

    CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-15, 2026, DOI:10.32604/cmc.2025.069128 - 10 November 2025

    Abstract This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks (SAGIN) through a novel Recursive Multi-Agent Proximal Policy Optimization (RMAPPO) algorithm. The exponential growth of mobile devices and data traffic has substantially increased network congestion, particularly in urban areas and regions with limited terrestrial infrastructure. Our approach jointly optimizes unmanned aerial vehicle (UAV) trajectories and satellite-assisted offloading strategies to simultaneously maximize data throughput, minimize energy consumption, and maintain equitable resource distribution. The proposed RMAPPO framework incorporates recurrent neural networks (RNNs) to model temporal dependencies in UAV mobility patterns and utilizes a decentralized multi-agent More >

  • Open Access

    EDITORIAL

    Current practices and future directions in prostate biopsy techniques: insights from a meta-analysis and european multicenter survey

    Xingkang Jiang*, Jing Tian, Yong Xu

    Canadian Journal of Urology, Vol.32, No.6, pp. 539-540, 2025, DOI:10.32604/cju.2025.073363 - 30 December 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Current and perceived optimal use of point-of-care ultrasound in urology

    Charles H. Schlaepfer1, Zubin Shetty1, Vignesh T. Packiam1, Chad R. Tracy1, Elizabeth B. Takacs1, Ruslan Korets2, Ryan L. Steinberg1,*

    Canadian Journal of Urology, Vol.32, No.6, pp. 643-649, 2025, DOI:10.32604/cju.2025.064818 - 30 December 2025

    Abstract Introduction: Point-of-care ultrasound (POCUS) is a valuable tool for clinicians, but little data exists regarding the perceptions of ideal POCUS utilization, as compared to actual use, amongst urologists. We aim to assess how perceptions align or diverge with actual practice. Methods: An institutional review board (IRB)-approved survey was developed and disseminated by email to 6 of 8 American Urologic Association Sections, program directors via the Society of Academic Urologists, and to 2 residency programs. The primary outcome was to assess differences in current and perceived optimal use. Data was collected via the University of Iowa… More >

  • Open Access

    MINI REVIEW

    Urinary Biomarkers for Parkinson’s Disease: Current Insights

    Ilhong Son1,2, Sun Jung Han2, Dong Hwan Ho1,3,*

    BIOCELL, Vol.49, No.12, pp. 2283-2297, 2025, DOI:10.32604/biocell.2025.071119 - 24 December 2025

    Abstract The potential of urinary biomarkers to facilitate non-invasive monitoring of Parkinson’s disease (PD) is a promising avenue, offering insights into the complex pathophysiology of the disease. The aggregation of α-synuclein, a central feature of PD, can be detected in urine, providing a diagnostic clue. Mutations in the LRRK2 gene, associated with increased kinase activity, can be estimated through the measurement of phosphorylated LRRK2 (pS1292) in urine. Oxidative stress, a hallmark of PD, is reflected in elevated levels of oxidized DJ-1 (oxDJ-1) in urine. Beyond these core biomarkers, other urinary components like DOPA decarboxylase, acetyl phenylalanine, More >

  • Open Access

    ARTICLE

    Attention-Enhanced CNN-GRU Method for Short-Term Power Load Forecasting

    Zheng Yin, Zhao Zhang*

    Journal on Artificial Intelligence, Vol.7, pp. 633-645, 2025, DOI:10.32604/jai.2025.074450 - 24 December 2025

    Abstract Power load forecasting load forecasting is a core task in power system scheduling, operation, and planning. To enhance forecasting performance, this paper proposes a dual-input deep learning model that integrates Convolutional Neural Networks, Gated Recurrent Units, and a self-attention mechanism. Based on standardized data cleaning and normalization, the method performs convolutional feature extraction and recurrent modeling on load and meteorological time series separately. The self-attention mechanism is then applied to assign weights to key time steps, after which the two feature streams are flattened and concatenated. Finally, a fully connected layer is used to generate More >

  • Open Access

    ARTICLE

    Investigation of temporal characteristics of photosensitive heterostructures based on gallium arsenide and silicon

    F. A. Giyasovaa, M. A. Yuldoshevb,d,*

    Chalcogenide Letters, Vol.22, No.2, pp. 123-129, 2025, DOI:10.15251/CL.2025.222.123

    Abstract The paper briefly describes the methodology for studying the temporal characteristics of near-IR photodiode structures under the influence of pulsed radiation from a semiconductor laser with a wavelength of 1100 and 1320 nm. The results of studying the response time of multilayer photosensitive Au-nCdS-nSi-pCdTe-Au and Au-nInP-nCdSνGaAs:O-Au structures with potential barriers are presented. It has been experimentally shown that the structures under study are not inferior in response time to known analogs based on gallium arsenide and silicon heterostructures, and can also be used in a wide optical range. More >

  • Open Access

    ARTICLE

    Influence of Ag content on direct current conductivity of Agx(As2(Te0.5Se0.5)3)100-x system

    G. R. Štrbaca,*, O. Bošákb, D. Štrbacc, R. Vigia, M. Kublihab, S. Minárikb

    Chalcogenide Letters, Vol.22, No.5, pp. 481-491, 2025, DOI:10.15251/CL.2025.225.481

    Abstract The temperature dependence of direct current (DC) conductivity, silver content, and the presence of crystalline phases in amorphous and annealed chalcogenides from the Agx(As2(Te0.5Se0.5)3)100-x system was investigated. Amorphous samples exhibited semiconducting behavior, with conductivity increase as the silver content raised. This increase was primarily attributed to electron transitions into delocalized states from states localized near the Fermi level. Percolation behavior in conductivity was observed in the samples containing 7 at.% or more silver. For annealed samples with silver content below 9 at.%, temperature-independent DC conductivity was identified, accompanied by a decrease in conductivity as the silver More >

  • Open Access

    ARTICLE

    Real-World Data on Stage III Non-Small Cell Lung Cancer in Vietnam

    Khanh Toan Nguyen1,*, Thi Huong Pham1,2, Van Lam Ngo1, Thi Thuy My Nguyen1, Thi Dao Nguyen1, Khanh Hung Truong1, Van Nhat Nguyen1, Van Thanh Le1, Ba Duc Ho1, Thi Phuong Thao Nguyen1, Thi Ha Phuong Nguyen1, Thi My Linh Dinh1, Thi Hong Anh Vo1, Thi Thuy Phan1, Thi Hai Yen Le1, Thi Nhung Ngo1, Khanh Ha Nguyen1

    Oncology Research, Vol.33, No.12, pp. 4013-4028, 2025, DOI:10.32604/or.2025.069281 - 27 November 2025

    Abstract Objective: Patients with stage III non-small cell lung cancer (NSCLC) present with a heterogeneous disease profile and often require multifaceted treatment strategies. This research aimed to investigate the demographic features, therapeutic patterns, and survival outcomes of such patients in Vietnam. Methods: A retrospective descriptive study was conducted on 731 patients diagnosed with stage III NSCLC American Joint Committee on Cancer (AJCC) 8th edition, at Nghe An Oncology Hospital from January 2018 to August 2024. Descriptive statistics summarized baseline and treatment characteristics. We calculated progression-free survival (PFS) and overall survival (OS) through the Kaplan–Meier approach and… More >

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