Rafl M. Kamil¹, Shaik Nyamathulla^1,*, Syed Mahmood^1,2,3,4,*

Journal of Polymer Materials, Vol.42, No.4, pp. 959-992, 2025, DOI:10.32604/jpm.2025.072005 - 26 December 2025

Abstract With the global diabetes epidemic, diabetic foot ulcers (DFUs) have become a major health burden, affecting approximately 18 million people worldwide each year, and account for about 80% of diabetes-related amputations. Five-year mortality among DFU patients approaches 30%, which is comparable to that of many malignancies. Yet despite standard wound care, only about 30%–40% of chronic DFUs achieve complete healing within 12 weeks. This persistent failure shows that conventional dressings remain passive supports. They do not counteract underlying pathologies such as ischemia, prolonged inflammation, and infection. Recent advances in polymeric nanofiber scaffolds, particularly electrospun matrices,… More > Graphic Abstract

Huaao Jiang^#, Bianyifan Xu^#, Yang Gui, Ying Xia, Xu Yin, Chao Zhang, Yue Meng, Xin Yu, Yan Wang, Hongmei Xia^*

Journal of Polymer Materials, Vol.42, No.4, pp. 993-1033, 2025, DOI:10.32604/jpm.2025.071740 - 26 December 2025

Abstract Traditional Chinese medicine (TCM) has a long history and is widely used to prevent and treat various diseases. With the development of modern technology, an increasing number of active ingredients—such as curcumin, berberine, and baicalin—have been identified and validated within TCM. Concurrently, the emergence of nanotechnology has led to the discovery of numerous nanomedicines based on the self-assembly of active ingredients from TCM. Polymer materials can enhance the bioavailability of these active compounds and reduce their toxic side effects. Moreover, compared to synthetic polymers, natural polymer materials offer advantages such as non-toxicity and high biosafety… More >

Shaojian Zou^1,#, Lipeng Zhang^2,#, Xiang Chen^3,#, Zhuomin Wang², Xinhui Zhu², Dandong Luo⁴, Shengxun Mao^2,*, Zhen Zong^2,*

Oncology Research, Vol.33, No.12, pp. 3753-3788, 2025, DOI:10.32604/or.2025.067586 - 27 November 2025

Abstract Traditional cancer therapies have limitations like poor efficacy on advanced tumors, healthy tissue damage, side effects, and drug resistance, creating an urgent need for new strategies. Hydrogels have good biocompatibility and controlled release, while extracellular vesicles (EVs) enable targeting and bioactive transport. This review systematically summarizes hydrogels and EVs, focusing on the construction of hydrogel-EV delivery system, key influencing factors, drug delivery mechanisms, and tumor therapy apps, clarifying their synergies. The system overcomes single-carrier flaws, construction methods/key factors affect performance, preclinical studies have confirmed efficacy in multiple therapies, but large-scale production and in vivo stability challenges More >

Yifei Wang, Xiaoxiao Han^*, Miaomiao Yuan, Yangguang Zhao, Wei Zhu, Feng Chen

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-1, 2025, DOI:10.32604/icces.2025.012585

Abstract With the advancement of the personalised medicine industry, multi-material targeted drug delivery systems have garnered significant attention due to the higher drug bioavailability and synergistic effects of combined drug therapies. However, the fabrication throughput of such systems often fails to satisfy the demands of clinical applications. Volumetric printing, distinguished by its remarkable capability for rapid fabrication, presents a promising approach for fabricating these systems. Nevertheless, during volumetric printing, formed parts are prone to displacement relative to their intended locations due to variations in ink density, viscosity, and other factors, resulting in geometric distortion and complicating… More >

Livanshee Gupta¹, Nouha Haoudi^2,3,*, Lanjelina Oinam¹, Ananya Mahajan¹, Sonia Morya^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2669-2700, 2025, DOI:10.32604/phyton.2025.065058 - 30 September 2025

Abstract The trends of consuming or using eco-friendly, biodegradable products due to the change in the lifestyle of the people have led to the exploration of new sources from plants or animals. Seed mucilage (SeM) is an underexplored component of plants that can be brought into play to deal with such problems. Mucilage, a viscous polysaccharide that can be obtained when seeds like chia, flax, garden cress, and tomato get hydrated and form a slimy, gel-like substance around the seed coat, can be utilized due to its unique characteristics. It has been used in developing many… More >

CHIOMA C. EZEUKO^#, SANDANI V. T. WIJERATHNE^#, QIANA L. MATTHEWS^*

BIOCELL, Vol.49, No.9, pp. 1605-1629, 2025, DOI:10.32604/biocell.2025.065474 - 25 September 2025

Abstract Extracellular vesicles (EVs) have arisen as potential therapeutic tools in managing infectious diseases because EVs can regulate cell-to-cell signaling, function as drug transport mechanisms, and influence immune reactions. They are obtained from a myriad of sources, such as plants, humans, and animal cells. EVs like exosomes and ectosomes can be utilized in their native form as therapeutics or engineered to encompass antimicrobials, vaccines, and oligonucleotides of interest with a targeted delivery strategy. An in-depth understanding of host-pathogen dynamics provides a solid foundation for exploiting its full potential in therapeutics against infectious diseases. This review mainly More >

Tri Susanti^1,2, Syahnur Haqiqoh¹, Pratiwi Pudjiastuti^2,*, Siti Wafiroh^2,*, Esti Hendradi³, Oktavia Eka Puspita⁴, Nashriq Jailani⁵

Journal of Renewable Materials, Vol.13, No.9, pp. 1841-1857, 2025, DOI:10.32604/jrm.2025.02024-0084 - 22 September 2025

Abstract This study aims to enhance the mechanical properties, disintegration, and dissolution rates of cross-linked carrageenan (CRG) capsule shells by shortening the long chains of CRG through a hydrolysis reaction with citric acid (CA). The hydrolysis of CRG was carried out using varying concentrations of CA, resulting in hydrolyzed CRG (HCRG). This was followed by cross-linking with xanthan gum (XG) and the addition of sorbitol (SOR) as a plasticizer. The results indicated that the optimal swelling capacity of HCRG-XG/SOR hard-shell capsules occurred at a CA concentration of 0.5%, achieving a maximum swelling rate of 445.39% after… More >

Wan Mohd Faizal^1,2,*, Nurul Musfirah Mazlan^1,*, Shazril Imran Shaukat^3,4, Chu Yee Khor², Ab Hadi Mohd Haidiezul², Abdul Khadir Mohamad Syafiq²

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 1335-1369, 2025, DOI:10.32604/cmes.2025.068660 - 31 August 2025

Abstract Conventional oncology faces challenges such as suboptimal drug delivery, tumor heterogeneity, and therapeutic resistance, indicating a need for more personalized, and mechanistically grounded and predictive treatment strategies. This review explores the convergence of Computational Fluid Dynamics (CFD) and Machine Learning (ML) as an integrated framework to address these issues in modern cancer therapy. The paper discusses recent advancements where CFD models simulate complex tumor microenvironmental conditions, like interstitial fluid pressure (IFP) and drug perfusion, and ML enhances simulation workflows, automates image-based segmentation, and enhances predictive accuracy. The synergy between CFD and ML improves scalability and More >

MERYEM A. ABDESSALEM, SIRIN A. ADHAM^*

Oncology Research, Vol.33, No.1, pp. 27-44, 2025, DOI:10.32604/or.2024.056955 - 20 December 2024

Abstract Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously. Despite these benefits, challenges remain in patient-specific responses and regulatory approvals for cell-based or nanoparticle therapies. Cell-based drug delivery systems (DDSs) that primarily utilize the immune-recognition principle between… More > Graphic Abstract

NOELIA L. D´ELĺA^1,2, A. NOEL GRAVINA^1,2, LUCIANO A. BENEDINI^2,3,*, PAULA V. MESSINA^1,2

BIOCELL, Vol.48, No.10, pp. 1401-1403, 2024, DOI:10.32604/biocell.2024.055512 - 02 October 2024

Abstract This work shows relevant interactions between cells and drug-delivery systems based on vesicles crucial for therapeutic activity. This interplay drives strategies for the design of new drug-carry. Among the described systems are found liposomes, extracellular vesicles, and hybrid systems. The text details their properties, advantages, and constraints, and eventually, a perspective about the future of these formulations is proposed. More >