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  • Open Access

    ARTICLE

    Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

    Thean Heng Tan1, Najihah Mohd Hashim2, Wageeh Abdulhadi Yehya Dabdawb1, Mochamad Zakki Fahmi3,*, Hwei Voon Lee1,*

    Journal of Renewable Materials, Vol.12, No.1, pp. 29-43, 2024, DOI:10.32604/jrm.2023.043449

    Abstract The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose (NCC) as a potential drug delivery system for targeting folate receptor-positive cancer cells. The FA-functionalized NCCs were synthesized through a series of chemical reactions, resulting in nanoparticles with favorable properties for biomedical applications. The microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor tissues. Importantly, these nanoparticles possessed a negative surface charge, enhancing their stability and repelling potential aggregation. The binding specificity of FA-functionalized NCCs to folate… More > Graphic Abstract

    Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

  • Open Access

    VIEWPOINT

    Mesenchymal stem cells-derived extracellular vesicles as ‘natural’ drug delivery system for tissue regeneration

    KENJI TSUJI*, SHINJI KITAMURA, JUN WADA

    BIOCELL, Vol.46, No.4, pp. 899-902, 2022, DOI:10.32604/biocell.2022.018594

    Abstract Mesenchymal stem cells (MSCs) have abilities to mediate tissue protection through mechanisms of anti-apoptosis, anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferation, differentiation and angiogenesis. These effects by MSCs are mediated by a variety of factors, including growth factors, cytokines and extracellular vesicles (EVs). Among these factors, EVs, containing proteins, mRNA and microRNAs (miRNA), may carry their contents into distant tissues with high stability. Therefore, the treatment with MSC-derived EVs may be promising as ‘natural’ drug delivery systems (DDS). Especially, the treatment of MSC-derived EVs with the manipulation of specific miRNAs expression has been… More >

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