Prabhakaran Mathialagan^*, Malathy Chidambaranathan

Intelligent Automation & Soft Computing, Vol.31, No.2, pp. 929-946, 2022, DOI:10.32604/iasc.2022.020163

Abstract Nasal cavity and paranasal sinus tumours that occur in the respiratory tract are the most life-threatening disease in the world. The human respiratory tract has many sites which has different mucosal lining like frontal, parred, sphenoid and ethmoid sinuses. Nasal cavity tumours can occur at any different mucosal linings and chances of prognosis possibility from one nasal cavity site to another site is very high. The paranasal sinus tumours can metastases to oral cavity and digestive tracts may lead to excessive survival complications. Grading the respiratory tract tumours with dysplasia cases are more challenging using manual pathological procedures. Manual microscopic… More >

Afzan Adam^1,*, Abdul Hadi Abd Rahman¹, Nor Samsiah Sani¹, Zaid Abdi Alkareem Alyessari¹, Nur Jumaadzan Zaleha Mamat², Basela Hasan³

CMC-Computers, Materials & Continua, Vol.67, No.1, pp. 761-777, 2021, DOI:10.32604/cmc.2021.014599

Abstract Boundary effect in digital pathology is a phenomenon where the tissue shapes of biopsy samples get distorted during the sampling process. The morphological pattern of an epithelial layer is greatly affected. Theoretically, the shape deformation model can normalise the distortions, but it needs a 2D image. Curvatures theory, on the other hand, is not yet tested on digital pathology images. Therefore, this work proposed a curvature detection to reduce the boundary effects and estimates the epithelial layer. The boundary effect on the tissue surfaces is normalised using the frequency of a curve deviates from being a straight line. The epithelial… More >

Kinjal Parikh^1,2,*, Juan Carlos Muniz^1,2, Elizabeth Welch^1,2, Abdul Aldousany^1,3, Nao Sasaki^1,2

Congenital Heart Disease, Vol.15, No.5, pp. 339-346, 2020, DOI:10.32604/CHD.2020.012910

Abstract This is a newborn male prenatally diagnosed with severe right ventricular (RV) hypertrophy and depressed function, aneurysmal dilation of the main pulmonary artery and tachyarrhythmia. Postnatally, he required immediate intubation and inotropic support. Echocardiogram revealed a large dysplastic RV, absent pulmonary valve syndrome (APVS), markedly dilated pulmonary arteries and tricuspid atresia (TA). The trabecular portion of the RV was excessively trabeculated and severely dilated. Inflow and infundibular walls were thin, with multiple infundibular aneurysms. There was APVS with free regurgitation and massively dilated pulmonary arteries. The RV bulged into the LV, though there was no outflow tract obstruction. The LV… More >

Kailyn Anderson¹, James Cnota^2,3, Jeanne James^4,5, Erin M. Miller^2,3, Ashley Parrott³, Valentina Pilipenko^1,2, Kathryn Nicole Weaver^1,2, Amy Shikany³

Congenital Heart Disease, Vol.14, No.2, pp. 264-273, 2019, DOI:10.1111/chd.12721

Abstract Objective: To evaluate the prevalence of Noonan spectrum disorders (NSD) in a pediatric population with valvar pulmonary stenosis (vPS) and identify the clinical characteristics that differentiate those with NSD from those without NSD.
Design: A retrospective chart review of 204 patients diagnosed with vPS between 9/1/2012 and 12/1/2016 at a pediatric medical center was performed. The quantitative features of vPS, genetic diagnosis information, and phenotypic characteristics of Noonan syndrome were collected. Chi‐square test, Fisher’s exact test, t test, Wilcoxon rank‐sum test, and ANOVA were used for comparisons among the groups. Logistic regression was used to test for the association between… More >

Meera N. Sankar, Shazia Bhombal, William E. Benitz

Congenital Heart Disease, Vol.14, No.1, pp. 46-51, 2019, DOI:10.1111/chd.12708

Abstract Management of patent ductus arteriosus in extremely preterm infants remains a topic of debate. Treatment to produce ductal closure was widely practiced until the past decade, despite lack of evidence that it decreases morbidities or mortality. Meta‐analyses of trials using nonsteroidal anti‐inflammatory drugs have shown ef‐ fectiveness in accelerating ductal closure, but no reduction in neonatal morbidities, regardless of agent used, indication, timing, gestational age, or route of administra‐ tion. Surgical ligation closes the ductus but is associated with adverse effects. Recent experience with conservative approaches to treatment suggest improved neonatal outcomes and a high rate of spontaneous ductal closure… More >

Kent A. Willis, Mark F. Weems

Congenital Heart Disease, Vol.14, No.1, pp. 27-32, 2019, DOI:10.1111/chd.12691

Abstract Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been linked to the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication of premature birth. Although a causal relationship has not been proven, the link is greatest among infants born at lower gestational age who are treated with mechanical ventilation in the presence of a large ductal shunt. Despite strong association in epidemiological studies, treatment of a patent ductus arteriosus has not been shown to prevent BPD, and some therapies may increase the risk of BPD. We describe preclinical and clinical data demonstrating the association of a PDA… More >