Manaliben Amin^*

Journal on Artificial Intelligence, Vol.8, pp. 1-18, 2026, DOI:10.32604/jai.2026.073895 - 07 January 2026

Abstract Artificial intelligence (AI) is steadily making its way into pharmaceutical validation, where it promises faster documentation, smarter testing strategies, and better handling of deviations. These gains are attractive, but in a regulated environment speed is never enough. Regulators want assurance that every system is reliable, that decisions are explainable, and that human accountability remains central. This paper sets out a Human-in-the-Loop (HITL) AI approach for Computer System Validation (CSV) and Computer Software Assurance (CSA). It relies on explainable AI (XAI) tools but keeps structured human review in place, so automation can be used without creating… More >

Eman Alsalmi, Abeer Alhuzali^*, Areej Alhothali

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-20, 2026, DOI:10.32604/cmc.2025.071012 - 09 December 2025

Abstract Log anomaly detection is essential for maintaining the reliability and security of large-scale networked systems. Most traditional techniques rely on log parsing in the reprocessing stage and utilize handcrafted features that limit their adaptability across various systems. In this study, we propose a hybrid model, BertGCN, that integrates BERT-based contextual embedding with Graph Convolutional Networks (GCNs) to identify anomalies in raw system logs, thereby eliminating the need for log parsing. The BERT module captures semantic representations of log messages, while the GCN models the structural relationships among log entries through a text-based graph. This combination More >

Muhammad Adil¹, Nadeem Javaid^1,*, Imran Ahmed², Abrar Ahmed³, Nabil Alrajeh^4,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-20, 2026, DOI:10.32604/cmc.2025.071215 - 10 November 2025

Abstract Heart disease remains a leading cause of mortality worldwide, emphasizing the urgent need for reliable and interpretable predictive models to support early diagnosis and timely intervention. However, existing Deep Learning (DL) approaches often face several limitations, including inefficient feature extraction, class imbalance, suboptimal classification performance, and limited interpretability, which collectively hinder their deployment in clinical settings. To address these challenges, we propose a novel DL framework for heart disease prediction that integrates a comprehensive preprocessing pipeline with an advanced classification architecture. The preprocessing stage involves label encoding and feature scaling. To address the issue of… More >

Amjad Rehman^1,*, Tanzila Saba¹, Mona M. Jamjoom², Shaha Al-Otaibi³, Muhammad I. Khan¹

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-15, 2026, DOI:10.32604/cmc.2025.068958 - 10 November 2025

Abstract Modern intrusion detection systems (MIDS) face persistent challenges in coping with the rapid evolution of cyber threats, high-volume network traffic, and imbalanced datasets. Traditional models often lack the robustness and explainability required to detect novel and sophisticated attacks effectively. This study introduces an advanced, explainable machine learning framework for multi-class IDS using the KDD99 and IDS datasets, which reflects real-world network behavior through a blend of normal and diverse attack classes. The methodology begins with sophisticated data preprocessing, incorporating both RobustScaler and QuantileTransformer to address outliers and skewed feature distributions, ensuring standardized and model-ready inputs.… More >

Jaeho Shin¹, Jaekwang Kim^2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-26, 2026, DOI:10.32604/cmc.2025.068767 - 10 November 2025

Abstract Network attacks have become a critical issue in the internet security domain. Artificial intelligence technology-based detection methodologies have attracted attention; however, recent studies have struggled to adapt to changing attack patterns and complex network environments. In addition, it is difficult to explain the detection results logically using artificial intelligence. We propose a method for classifying network attacks using graph models to explain the detection results. First, we reconstruct the network packet data into a graphical structure. We then use a graph model to predict network attacks using edge classification. To explain the prediction results, we… More >

Omar Darwish¹, Shorouq Al-Eidi², Abdallah Al-Shorman¹, Majdi Maabreh³, Anas Alsobeh⁴, Plamen Zahariev⁵, Yahya Tashtoush^6,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-21, 2026, DOI:10.32604/cmc.2025.068266 - 10 November 2025

Abstract Covert timing channels (CTC) exploit network resources to establish hidden communication pathways, posing significant risks to data security and policy compliance. Therefore, detecting such hidden and dangerous threats remains one of the security challenges. This paper proposes LinguTimeX, a new framework that combines natural language processing with artificial intelligence, along with explainable Artificial Intelligence (AI) not only to detect CTC but also to provide insights into the decision process. LinguTimeX performs multidimensional feature extraction by fusing linguistic attributes with temporal network patterns to identify covert channels precisely. LinguTimeX demonstrates strong effectiveness in detecting CTC across… More >

MD Hamid Borkot Tulla^1,*, MD Moniur Rahman Ratan², Rashid MD Mamunur³, Abdullah Hil Safi Sohan⁴, MD Matiur Rahman⁵

Journal of Cyber Security, Vol.7, pp. 675-691, 2025, DOI:10.32604/jcs.2025.074737 - 24 December 2025

Abstract Phishing is considered one of the most widespread cybercrimes due to the fact that it combines both technical and human vulnerabilities with the intention of stealing sensitive information. Traditional blacklist and heuristic-based defenses fail to detect such emerging attack patterns; hence, intelligent and transparent detection systems are needed. This paper proposes an explainable machine learning framework that integrates predictive performance with regulatory accountability. Four models were trained and tested on a balanced dataset of 10,000 URLs, comprising 5000 phishing and 5000 legitimate samples, each characterized by 48 lexical and content-based features: Decision Tree, XGBoost, Logistic… More >

Khulud Salem Alshudukhi^1,*, Sijjad Ali², Mamoona Humayun^3,*, Omar Alruwaili⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3029-3085, 2025, DOI:10.32604/cmes.2025.073705 - 23 December 2025

Abstract Problem: The integration of Artificial Intelligence (AI) into cybersecurity, while enhancing threat detection, is hampered by the “black box” nature of complex models, eroding trust, accountability, and regulatory compliance. Explainable AI (XAI) aims to resolve this opacity but introduces a critical new vulnerability: the adversarial exploitation of model explanations themselves. Gap: Current research lacks a comprehensive synthesis of this dual role of XAI in cybersecurity—as both a tool for transparency and a potential attack vector. There is a pressing need to systematically analyze the trade-offs between interpretability and security, evaluate defense mechanisms, and outline a… More >

Asma Batool¹, Fahad Ahmed¹, Naila Sammar Naz¹, Ayman Altameem², Ateeq Ur Rehman^3,4, Khan Muhammad Adnan^5,*, Ahmad Almogren^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4129-4152, 2025, DOI:10.32604/cmes.2025.073149 - 23 December 2025

Abstract Early and accurate cancer diagnosis through medical imaging is crucial for guiding treatment and enhancing patient survival. However, many state-of-the-art deep learning (DL) methods remain opaque and lack clinical interpretability. This paper presents an explainable artificial intelligence (XAI) framework that combines a fine-tuned Visual Geometry Group 16-layer network (VGG16) convolutional neural network with layer-wise relevance propagation (LRP) to deliver high-performance classification and transparent decision support. This approach is evaluated on the publicly available Kaggle kidney cancer imaging dataset, which comprises labeled cancerous and non-cancerous kidney scans. The proposed model achieved 98.75% overall accuracy, with precision, More >

Mubashir Ali^1,2, Jingzhen Li¹, Zedong Nie^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4153-4177, 2025, DOI:10.32604/cmes.2025.073048 - 23 December 2025

Abstract Diabetes imposes a substantial burden on global healthcare systems. Worldwide, nearly half of individuals with diabetes remain undiagnosed, while conventional diagnostic techniques are often invasive, painful, and expensive. In this study, we propose a noninvasive approach for diabetes detection using photoplethysmography (PPG), which is widely integrated into modern wearable devices. First, we derived velocity plethysmography (VPG) and acceleration plethysmography (APG) signals from PPG to construct multi-channel waveform representations. Second, we introduced a novel multiset spatiotemporal feature fusion framework that integrates hand-crafted temporal, statistical, and nonlinear features with recursive feature elimination and deep feature extraction using… More >