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  • Open Access

    ARTICLE

    Numerical Exploration of Asymmetrical Impact Dynamics: Unveiling Nonlinearities in Collision Problems and Resilience of Reinforced Concrete Structures

    AL-Bukhaiti Khalil1, Yanhui Liu1,*, Shichun Zhao1, Daguang Han2

    Structural Durability & Health Monitoring, Vol.18, No.3, pp. 223-254, 2024, DOI:10.32604/sdhm.2024.044751

    Abstract This study provides a comprehensive analysis of collision and impact problems’ numerical solutions, focusing on geometric, contact, and material nonlinearities, all essential in solving large deformation problems during a collision. The initial discussion revolves around the stress and strain of large deformation during a collision, followed by explanations of the fundamental finite element solution method for addressing such issues. The hourglass mode’s control methods, such as single-point reduced integration and contact-collision algorithms are detailed and implemented within the finite element framework. The paper further investigates the dynamic response and failure modes of Reinforced Concrete (RC)… More >

  • Open Access

    ARTICLE

    Predicting Age and Gender in Author Profiling: A Multi-Feature Exploration

    Aiman1, Muhammad Arshad1,*, Bilal Khan1, Sadique Ahmad2,*, Muhammad Asim2,3

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 3333-3353, 2024, DOI:10.32604/cmc.2024.049254

    Abstract Author Profiling (AP) is a subsection of digital forensics that focuses on the detection of the author’s personal information, such as age, gender, occupation, and education, based on various linguistic features, e.g., stylistic, semantic, and syntactic. The importance of AP lies in various fields, including forensics, security, medicine, and marketing. In previous studies, many works have been done using different languages, e.g., English, Arabic, French, etc. However, the research on Roman Urdu is not up to the mark. Hence, this study focuses on detecting the author’s age and gender based on Roman Urdu text messages.… More >

  • Open Access

    ARTICLE

    Genome-Wide Exploration of the Grape GLR Gene Family and Differential Responses of VvGLR3.1 and VvGLR3.2 to Low Temperature and Salt Stress

    Honghui Sun1,2,#, Ruichao Liu1,2,#, Yueting Qi1, Hongsheng Gao1, Xueting Wang1, Ning Jiang1,2, Xiaotong Guo1,2, Hongxia Zhang1, Chunyan Yu1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 533-549, 2024, DOI:10.32604/phyton.2024.049417

    Abstract Grapes, one of the oldest tree species globally, are rich in vitamins. However, environmental conditions such as low temperature and soil salinization significantly affect grape yield and quality. The glutamate receptor (GLR) family, comprising highly conserved ligand-gated ion channels, regulates plant growth and development in response to stress. In this study, 11 members of the VvGLR gene family in grapes were identified using whole-genome sequence analysis. Bioinformatic methods were employed to analyze the basic physical and chemical properties, phylogenetic trees, conserved domains, motifs, expression patterns, and evolutionary relationships. Phylogenetic and collinear analyses revealed that the VvGLRs… More >

  • Open Access

    ARTICLE

    Evaluation of combined detection of nuclear factor erythroid 2-related factor 2 and glutathione peroxidase 4 in primary hepatic carcinoma and preliminary exploration of pathogenesis

    JIE DUAN, AIDONG GU*, WEI CHEN, CHANGHAO CHEN, FANGNAN SONG, FAXI CHEN, FANGFANG JIANG, HUIWEN XING

    BIOCELL, Vol.47, No.12, pp. 2609-2615, 2023, DOI:10.32604/biocell.2023.042472

    Abstract Objective: This study aims to analyze the clinical significance and mechanism of nuclear factor erythroid 2-related factor 2 (NRF2) and glutathione peroxidase 4 (GPX4) in primary hepatic carcinoma (PHC). Methods: The expression of NRF2 and GPX4 in peripheral blood of patients with PHC was determined to analyze the diagnostic value of the two combined for PHC. The prognostic significance of NRF2 and GPX4 was evaluated by 3-year follow-up. Human liver epithelial cells THLE-2 and human hepatocellular carcinoma cells HepG2 were purchased, and the expression of NRF2 and GPX4 in the cells was determined. NRF2 and GPX4… More > Graphic Abstract

    Evaluation of combined detection of nuclear factor erythroid 2-related factor 2 and glutathione peroxidase 4 in primary hepatic carcinoma and preliminary exploration of pathogenesis

  • Open Access

    ARTICLE

    A New Exploration of Artificially Induced Spalted Wood of Two Fungi: Hypoxylon and Sistotrema

    Yan Yan, Junpeng Dong, Haibo Hu, Susu Yang, Lin Liu, Lei Qin*

    Journal of Renewable Materials, Vol.11, No.11, pp. 3907-3916, 2023, DOI:10.32604/jrm.2023.028099

    Abstract One strain of Hypoxylon sp. CXM-3 and one strain of Sistotrema brinkmannii CXM-4 were inoculated onto sterilized cherry, poplar, birch, and basswood sheets in a certain shape and incubated at constant temperature and humidity for 4, 8, 12, and 16 weeks, respectively, to analyze whether the grain pattern formed by the zone lines was consistent with the predetermined pattern. The results showed that the zone lines of CXM-3 of Hypoxylon were free, delicate, and soft, with brown lines and black staining, mostly accompanied by black and brown dots, facets, and clusters, while the zone lines of CXM-4 of… More > Graphic Abstract

    A New Exploration of Artificially Induced Spalted Wood of Two Fungi: <i>Hypoxylon</i> and <i>Sistotrema</i>

  • Open Access

    ARTICLE

    An Effective Runge-Kutta Optimizer Based on Adaptive Population Size and Search Step Size

    Ala Kana, Imtiaz Ahmad*

    CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3443-3464, 2023, DOI:10.32604/cmc.2023.040775

    Abstract A newly proposed competent population-based optimization algorithm called RUN, which uses the principle of slope variations calculated by applying the Runge Kutta method as the key search mechanism, has gained wider interest in solving optimization problems. However, in high-dimensional problems, the search capabilities, convergence speed, and runtime of RUN deteriorate. This work aims at filling this gap by proposing an improved variant of the RUN algorithm called the Adaptive-RUN. Population size plays a vital role in both runtime efficiency and optimization effectiveness of metaheuristic algorithms. Unlike the original RUN where population size is fixed throughout… More >

  • Open Access

    REVIEW

    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, Mpro, and PLpro: A review

    MOHAMAD ZULKEFLEE SABRI1, JOANNA BOJARSKA2, FAI-CHU WONG3,4, TSUN-THAI CHAI3,4,*

    BIOCELL, Vol.47, No.8, pp. 1727-1742, 2023, DOI:10.32604/biocell.2023.029272

    Abstract Molecular dynamics (MD) simulation is a computational technique that analyzes the movement of a system of particles over a given period. MD can provide detailed information about the fluctuations and conformational changes of biomolecules at the atomic level over time. In recent years, MD has been widely applied to the discovery of peptides and peptide-like molecules that may serve as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors. This review summarizes recent advances in such explorations, focusing on four protein targets: angiotensin-converting enzyme 2 (ACE2), spike protein (S protein), main protease (Mpro), and papain-like protease (PLpro).… More > Graphic Abstract

    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, M<sup>pro</sup>, and PL<sup>pro</sup>: A review

  • Open Access

    ARTICLE

    Migration Algorithm: A New Human-Based Metaheuristic Approach for Solving Optimization Problems

    Pavel Trojovský*, Mohammad Dehghani

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.2, pp. 1695-1730, 2023, DOI:10.32604/cmes.2023.028314

    Abstract This paper introduces a new metaheuristic algorithm called Migration Algorithm (MA), which is helpful in solving optimization problems. The fundamental inspiration of MA is the process of human migration, which aims to improve job, educational, economic, and living conditions, and so on. The mathematical modeling of the proposed MA is presented in two phases to empower the proposed approach in exploration and exploitation during the search process. In the exploration phase, the algorithm population is updated based on the simulation of choosing the migration destination among the available options. In the exploitation phase, the algorithm… More >

  • Open Access

    ARTICLE

    Exploration of the oxidative-inflammatory potential targets of Coicis Semen in osteoarthritis: Data mining and systematic pharmacology

    QIAO ZHOU2,3,4, JIAN LIU1,2,*, LING XIN1, YANYAN FANG1,2, LEI WAN1,2, DAN HUANG1,2, JIANTING WEN1,2

    BIOCELL, Vol.47, No.7, pp. 1623-1643, 2023, DOI:10.32604/biocell.2023.028331

    Abstract Objective: On the basis of data mining, systematic pharmacology, molecular docking, and experiment validation, the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis (OA) were explored. Methods: The association rule analysis was effectively applied to highlight the correlation between Coicis Semen and oxidative inflammation indices. The random walk model was subsequently used to evaluate the clinical efficacy of Coicis Semen. Network pharmacology was used to predict network targets. The binding affinity of the active ingredient in Coicis Semen to the key target of OA was also successfully predicted. Results: Coicis Semen showed a significant reduction in oxidative-inflammatory indicators… More >

  • Open Access

    ARTICLE

    DRUG RELEASE IN TRANSDERMAL DEVICES: A BRIEF PARAMETRIC STUDY

    F.C.C. Almeidaa , P.M. da Silvab,c, M.N.C. Coelho Pinheiroa,d,*

    Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-9, 2019, DOI:10.5098/hmt.12.16

    Abstract In the last decades, polymeric systems were essayed and applied successfully as vehicles for transdermal delivery devices of active principles. Applications in contraception, pain control, and smoking cessation are already frequent. A crucial aspect in the development of new formulations is the maintenance of the therapeutic drug concentration range for long periods. Recognizing this topic as interesting and challenging, simple models to describe drug release from a transdermal device were developed with the purpose to perform a parametric sensitivity analysis. Assuming drug diffusion within the polymeric delivery system as the dominant mechanism the models were More >

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