Honghui Sun^1,2,#, Ruichao Liu^1,2,#, Yueting Qi¹, Hongsheng Gao¹, Xueting Wang¹, Ning Jiang^1,2, Xiaotong Guo^1,2, Hongxia Zhang¹, Chunyan Yu^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 533-549, 2024, DOI:10.32604/phyton.2024.049417

Abstract Grapes, one of the oldest tree species globally, are rich in vitamins. However, environmental conditions such as low temperature and soil salinization significantly affect grape yield and quality. The glutamate receptor (GLR) family, comprising highly conserved ligand-gated ion channels, regulates plant growth and development in response to stress. In this study, 11 members of the VvGLR gene family in grapes were identified using whole-genome sequence analysis. Bioinformatic methods were employed to analyze the basic physical and chemical properties, phylogenetic trees, conserved domains, motifs, expression patterns, and evolutionary relationships. Phylogenetic and collinear analyses revealed that the VvGLRs were divided into three… More >

JIE DUAN, AIDONG GU^*, WEI CHEN, CHANGHAO CHEN, FANGNAN SONG, FAXI CHEN, FANGFANG JIANG, HUIWEN XING

BIOCELL, Vol.47, No.12, pp. 2609-2615, 2023, DOI:10.32604/biocell.2023.042472

Abstract Objective: This study aims to analyze the clinical significance and mechanism of nuclear factor erythroid 2-related factor 2 (NRF2) and glutathione peroxidase 4 (GPX4) in primary hepatic carcinoma (PHC). Methods: The expression of NRF2 and GPX4 in peripheral blood of patients with PHC was determined to analyze the diagnostic value of the two combined for PHC. The prognostic significance of NRF2 and GPX4 was evaluated by 3-year follow-up. Human liver epithelial cells THLE-2 and human hepatocellular carcinoma cells HepG2 were purchased, and the expression of NRF2 and GPX4 in the cells was determined. NRF2 and GPX4 aberrant expression vectors were… More > Graphic Abstract

Yan Yan, Junpeng Dong, Haibo Hu, Susu Yang, Lin Liu, Lei Qin^*

Journal of Renewable Materials, Vol.11, No.11, pp. 3907-3916, 2023, DOI:10.32604/jrm.2023.028099

Abstract One strain of Hypoxylon sp. CXM-3 and one strain of Sistotrema brinkmannii CXM-4 were inoculated onto sterilized cherry, poplar, birch, and basswood sheets in a certain shape and incubated at constant temperature and humidity for 4, 8, 12, and 16 weeks, respectively, to analyze whether the grain pattern formed by the zone lines was consistent with the predetermined pattern. The results showed that the zone lines of CXM-3 of Hypoxylon were free, delicate, and soft, with brown lines and black staining, mostly accompanied by black and brown dots, facets, and clusters, while the zone lines of CXM-4 of Sistotrema brinkmannii… More > Graphic Abstract

Ala Kana, Imtiaz Ahmad^*

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3443-3464, 2023, DOI:10.32604/cmc.2023.040775

Abstract A newly proposed competent population-based optimization algorithm called RUN, which uses the principle of slope variations calculated by applying the Runge Kutta method as the key search mechanism, has gained wider interest in solving optimization problems. However, in high-dimensional problems, the search capabilities, convergence speed, and runtime of RUN deteriorate. This work aims at filling this gap by proposing an improved variant of the RUN algorithm called the Adaptive-RUN. Population size plays a vital role in both runtime efficiency and optimization effectiveness of metaheuristic algorithms. Unlike the original RUN where population size is fixed throughout the search process, Adaptive-RUN automatically… More >

MOHAMAD ZULKEFLEE SABRI¹, JOANNA BOJARSKA², FAI-CHU WONG^3,4, TSUN-THAI CHAI^3,4,*

BIOCELL, Vol.47, No.8, pp. 1727-1742, 2023, DOI:10.32604/biocell.2023.029272

Abstract Molecular dynamics (MD) simulation is a computational technique that analyzes the movement of a system of particles over a given period. MD can provide detailed information about the fluctuations and conformational changes of biomolecules at the atomic level over time. In recent years, MD has been widely applied to the discovery of peptides and peptide-like molecules that may serve as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors. This review summarizes recent advances in such explorations, focusing on four protein targets: angiotensin-converting enzyme 2 (ACE2), spike protein (S protein), main protease (M^pro), and papain-like protease (PL^pro). These four proteins are… More > Graphic Abstract

Pavel Trojovský^*, Mohammad Dehghani

CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.2, pp. 1695-1730, 2023, DOI:10.32604/cmes.2023.028314

Abstract This paper introduces a new metaheuristic algorithm called Migration Algorithm (MA), which is helpful in solving optimization problems. The fundamental inspiration of MA is the process of human migration, which aims to improve job, educational, economic, and living conditions, and so on. The mathematical modeling of the proposed MA is presented in two phases to empower the proposed approach in exploration and exploitation during the search process. In the exploration phase, the algorithm population is updated based on the simulation of choosing the migration destination among the available options. In the exploitation phase, the algorithm population is updated based on… More >

QIAO ZHOU^2,3,4, JIAN LIU^1,2,*, LING XIN¹, YANYAN FANG^1,2, LEI WAN^1,2, DAN HUANG^1,2, JIANTING WEN^1,2

BIOCELL, Vol.47, No.7, pp. 1623-1643, 2023, DOI:10.32604/biocell.2023.028331

Abstract Objective: On the basis of data mining, systematic pharmacology, molecular docking, and experiment validation, the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis (OA) were explored. Methods: The association rule analysis was effectively applied to highlight the correlation between Coicis Semen and oxidative inflammation indices. The random walk model was subsequently used to evaluate the clinical efficacy of Coicis Semen. Network pharmacology was used to predict network targets. The binding affinity of the active ingredient in Coicis Semen to the key target of OA was also successfully predicted. Results: Coicis Semen showed a significant reduction in oxidative-inflammatory… More >

F.C.C. Almeida^a , P.M. da Silva^b,c, M.N.C. Coelho Pinheiro^a,d,*

Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-9, 2019, DOI:10.5098/hmt.12.16

Abstract In the last decades, polymeric systems were essayed and applied successfully as vehicles for transdermal delivery devices of active principles. Applications in contraception, pain control, and smoking cessation are already frequent. A crucial aspect in the development of new formulations is the maintenance of the therapeutic drug concentration range for long periods. Recognizing this topic as interesting and challenging, simple models to describe drug release from a transdermal device were developed with the purpose to perform a parametric sensitivity analysis. Assuming drug diffusion within the polymeric delivery system as the dominant mechanism the models were developed and implemented. Transdermal patches… More >

Musaed Alrashidi^*

Computer Systems Science and Engineering, Vol.47, No.1, pp. 491-513, 2023, DOI:10.32604/csse.2023.038628

Abstract Statistical distributions are used to model wind speed, and the two-parameters Weibull distribution has proven its effectiveness at characterizing wind speed. Accurate estimation of Weibull parameters, the scale (c) and shape (k), is crucial in describing the actual wind speed data and evaluating the wind energy potential. Therefore, this study compares the most common conventional numerical (CN) estimation methods and the recent intelligent optimization algorithms (IOA) to show how precise estimation of c and k affects the wind energy resource assessments. In addition, this study conducts technical and economic feasibility studies for five sites in the northern part of Saudi… More >

Anne Ruas, Ha Pham, Laura Pinson

Revue Internationale de Géomatique, Vol.29, No.2, pp. 185-205, 2019, DOI:10.3166/rig.2019.00081

Abstract De nombreuses études et recherches visent à mieux connaitre les phénomènes de type pollution ou météo. Les champs de valeur représentant ces phénomènes peuvent être visualisés sur des outils de visualisation scientifiques qui ne disposent pas de la richesse de symbolisation propre aux SIGs, notamment pour le géoréférencement et pour la représentation des objets vectoriels décrivant l’espace support. La représentation sous forme raster sur SIG est possible mais limitée. Pourtant au niveau scientifique il est important de pouvoir co-visualiser les champs dans leur contexte géographique pour mieux les analyser et faire des hypothèses sur les interactions entre un phénomène et… More >