J. H. Azzawi^a, Yaseen A. Al-Zahraa^b, M. A. Abdulmajeed^c, K. A. Jasim^c, A. Muravitskaya^e, A. A. Al-Hamadani^d,e, A. H. Al-Dulaimi^d,e

Chalcogenide Letters, Vol.22, No.7, pp. 593-601, 2025, DOI:10.15251/CL.2025.227.593

Abstract Four Se₇₀Ge₂₀Sb₁₀ alloy samples were prepared using the melt quenching technique. To improve the energy states of the mobility gap, the samples were exposed to gamma radiation from 60Co source at various doses of 600, 1200, 1500, and 2000 Gy. The electrical characteristics were examined both before and after irradiation. The conductivity analysis revealed that all of our samples were impacted by gamma radiation. The reorganization of the amorphous lattice and the degree of radiation-induced disorder have been involved in the changes that occurred in the electrical characteristics of the irradiated samples. All irradiated and non-irradiated… More >

Faraj M. Zaid^1,2, Thaar M. Aljuwaya^3,4,*, Muthanna H. Al-Dahhan^1,3,5,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.10, pp. 2443-2471, 2025, DOI:10.32604/fdmp.2025.067557 - 30 October 2025

Abstract This study presents a detailed experimental evaluation of a newly developed mechanistic scale-up methodology for gas-solid fluidized beds. Traditional scale-up approaches typically rely on matching global dimensionless groups, which often fail to ensure local hydrodynamic similarity. In contrast, the new mechanistic method aims to achieve scale-up by matching the radial profiles of gas holdup between geometrically similar beds at corresponding dimensionless axial positions (z/D_c). This approach is based on the premise that when gas holdup profiles align, other key hydrodynamic parameters—such as solids holdup and particle velocity—also become similar. To validate this methodology, experiments were conducted More >

Xiaobing Zhou^1,#, Ying Li^2,#, Zizi Jing¹, Wei Yu¹, Jianbin Chen^1,*

Oncology Research, Vol.33, No.9, pp. 2399-2420, 2025, DOI:10.32604/or.2025.063700 - 28 August 2025

Abstract Background: Multiple myeloma (MM) remains a formidable clinical challenge due to its high relapse rate and resistance to existing therapies. Estrogen-related receptor gamma (ERRγ), a nuclear receptor critical for cellular energy metabolism, has been implicated in various cancers. but its role in MM remains unclear. Methods: ERRγ expression was assessed using bioinformatics and RT-qPCR. Functional studies were conducted through siRNA-mediated ERRγ knockdown and treatment with the inverse agonist GSK5182 to examine their effects on MM cell proliferation and apoptosis. Results: ERRγ was significantly upregulated in the bone marrow of MM patients, correlating with advanced clinical stages… More > Graphic Abstract

Ehab M. Almetwally^1,*, O. M. Khaled², H. M. Barakat³

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 2957-2990, 2025, DOI:10.32604/cmes.2025.065446 - 30 June 2025

Abstract Accelerated life tests play a vital role in reliability analysis, especially as advanced technologies lead to the production of highly reliable products to meet market demands and competition. Among these tests, progressive-stress accelerated life tests (PSALT) allow for continuous changes in applied stress. Additionally, the generalized progressive hybrid censoring (GPHC) scheme has attracted significant attention in reliability and survival analysis, particularly for handling censored data in accelerated testing. It has been applied to various failure models, including competing risks and step-stress models. However, despite its growing relevance, a notable gap remains in the literature regarding… More >

MING YANG^1,#, LIANGZHAO CHU^1,#, SHUKAI LIN², HAN PENG¹, NIYA LONG¹, KAYA XU¹, HUA YANG¹, FENG HAN^1,*, JIAN LIU^1,*

Oncology Research, Vol.33, No.5, pp. 1189-1198, 2025, DOI:10.32604/or.2024.055102 - 18 April 2025

Abstract Background: Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors. Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. However, the mechanisms of hypoxia-promoted tumor progression remain elusive. Methods: Alternative splicing of diacylglycerol kinase gamma (DGKG)-Δ exon13 was amplified and verified by PCR-Sanger sequencing. The functions of DGKG and DGKG-Δ exon13 were analyzed by Cell counting kit-8 (CCK-8), Transwell, Matrigel-transwell experiments, and in vivo orthotropic GBM animal models. Transcriptome analyses were done to find out the regulated genes. Results: In this study, we found… More > Graphic Abstract

Pei Hu¹, Yibo Han¹, Jeng-Shyang Pan^2,3,*

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4485-4501, 2025, DOI:10.32604/cmc.2024.059773 - 06 March 2025

Abstract Image enhancement utilizes intensity transformation functions to maximize the information content of enhanced images. This paper approaches the topic as an optimization problem and uses the bald eagle search (BES) algorithm to achieve optimal results. In our proposed model, gamma correction and Retinex address color cast issues and enhance image edges and details. The final enhanced image is obtained through color balancing. The BES algorithm seeks the optimal solution through the selection, search, and swooping stages. However, it is prone to getting stuck in local optima and converges slowly. To overcome these limitations, we propose… More >

JING WANG^1,#, JUNFENG XU^2,#, YINGRAN YANG¹, YOUZHENG QIU¹, SHANSHAN ZHANG³, NING WANG^1,3,*

BIOCELL, Vol.48, No.9, pp. 1343-1353, 2024, DOI:10.32604/biocell.2024.051673 - 04 September 2024

Abstract Objective: This study aimed to elucidate the influence of IFN-gamma (IFN-γ) in neuroblastoma (NB) cells and reveal its potential underlying molecular mechanism. Methods: The Cell Counting Kit-8, Transwell apparatus, and flow cytometry were employed to assess cellular viability, migratory capacity, invasive potential, and apoptotic rates, respectively. RNA-seq combined with bioinformatics analysis revealed differentially expressed genes (DEGs) and their possible biological functions. Protein levels were determined by western blot analysis. Results: IFN-γ treatment resulted in diminished cell viability, mitigated migratory and invasive capabilities, and augmented apoptotic activity in the SK-N-BE (2) cell line, whereas it exhibited the… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.9, pp. 1527-1527, 2024, DOI:10.32604/or.2024.056120 - 23 August 2024

Abstract This article has no abstract. More >

Refah Alotaibi¹, Sanku Dey², Ahmed Elshahhat^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.1, pp. 459-489, 2024, DOI:10.32604/cmes.2024.053255 - 20 August 2024

Abstract A novel inverted generalized gamma (IGG) distribution, proposed for data modelling with an upside-down bathtub hazard rate, is considered. In many real-world practical situations, when a researcher wants to conduct a comparative study of the life testing of items based on cost and duration of testing, censoring strategies are frequently used. From this point of view, in the presence of censored data compiled from the most well-known progressively Type-II censoring technique, this study examines different parameters of the IGG distribution. From a classical point of view, the likelihood and product of spacing estimation methods are… More >

YANAN MA¹, SHANSHAN WANG^2,*, HUIGUO DING^1,*

BIOCELL, Vol.48, No.3, pp. 463-471, 2024, DOI:10.32604/biocell.2024.048244 - 15 March 2024

Abstract Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality worldwide. Although cystathionine-gamma-lyase (CSE) plays an important role in the development of multiple tumors, the clinical implication and potential mechanisms of CSE in HCC development remain elusive. Methods: In our study, the CSE expression in HCC was analyzed in Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets and further confirmed by RT-qPCR and immunohistochemistry assays in HCC samples. Furthermore, the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated… More >