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  • Open Access

    ARTICLE

    Chrysophanol inhibits the progression of gastric cancer by activating nod-like receptor protein-3

    BINFEN HOU1, LI ZHAO1, T IANHAO ZHAO1, MINGMING YANG1, WANWAN ZHU1, XIAODONG CHEN2, XIQUAN KE1, ZHENZENG MA1, LIN GU1, MENG WANG1, MIN DENG1,*

    BIOCELL, Vol.47, No.1, pp. 175-186, 2023, DOI:10.32604/biocell.2022.021359

    Abstract Aim: Gastric cancer (GC) is one of the most common malignant tumors. Chrysophanol has been reported to possess antitumor effects on a variety of cancers; however, its role in GC remains unclear. This study aimed to investigate the effects of chrysophanol on the proliferation, pyroptosis, migration, and invasion of GC cells. Methods: Human GC cell lines MKN 28 and AGS cells were treated with different concentrations of chrysophanol, then cell proliferation, migration, invasion and pyroptosis were determined by CCK-8, colony-forming assay, wound healing assay, Transwell assay, and flow cytometry. Cell migration and invasion were reassessed in… More >

  • Open Access

    ARTICLE

    Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1

    FANBIAO KONG1,2,#, KUN WU3,4,#, LIMING PANG2,#, YULIANG HUANG2,#, LEI LI3, JING XU2, FEITONG LI2, YAN QING2, ZHONGYU WANG2, XIURONG HUANG3, SHENG XU2, XIAOGANG ZHONG2, ZHOU ZHU2, XIAOTONG WANG3,*, JIANRONG YANG5,*

    Oncology Research, Vol.30, No.6, pp. 277-288, 2022, DOI:10.32604/or.2022.027301

    Abstract Introduction: Siva-1, as a pro-apoptotic protein, has been shown to induce extensive apoptosis in a number of different cell lines. In our previous study, we showed that overexpressed Siva-1 decreased the apoptosis of gastric cancer cells. So, we believe that it can also work as an anti-apoptotic protein. The present study aimed to determine the specific role of Siva-1 in anticancer drug resistance in gastric cancer in vivo and in vitro and preliminarily reveal the mechanism. Materials and Methods: A vincristine-resistant MKN-28/VCR gastric cancer cell line with stably downregulated Siva-1 was established. The effect of Siva-1 downregulation… More >

  • Open Access

    REVIEW

    The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study

    Abolfazl Jafari-Sales1, Afsoon Shariat1,*, Hossein Bannazadeh Baghi2, Behzad Baradaran3, Behboud Jafari4

    Oncologie, Vol.24, No.3, pp. 413-426, 2022, DOI:10.32604/oncologie.2022.024161

    Abstract Background and Aim: Gastric cancer (GC) is one of the most common infection-related malignancies worldwide. Human Papillomavirus (HPV) and Epstein-Barr virus (EBV) are among the most important viruses affecting many people worldwide. The potential role of these viruses in gastric tissue may explain the possibility of GC, as seen in Helicobacter pylori (H. pylori). This study aimed to systematically investigate the presence of HPV and EBV in GC. Methods: According to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, this study is a systematic review based on reported cases. The keywords HPV, EBV and GC, were… More >

  • Open Access

    CASE REPORT

    Gastric Cancer with Bone Marrow Invasion and Disseminated Intravascular Coagulation: A Case Report

    Lilan Chen, Lu Lu, Xinlei Gong, Yichen Xu, Xiaoyuan Chu*, Guichun Huang*

    Oncologie, Vol.24, No.3, pp. 599-604, 2022, DOI:10.32604/oncologie.2022.023310

    Abstract Gastric cancer is the fifth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide in 2020. Gastric cancer usually undergoes lymph node metastasis and implantation metastasis, but bone metastasis and bone marrow invasion are rare. However, gastric cancer patients with bone marrow invasion usually have cancer emergency, so special attention should be paid in clinical practice. Herein, we analyzed the clinical characteristics of an asian gastric cancer patient with bone marrow invasion and disseminated intravascular coagulation (DIC) in our hospital and summarized the diagnosis and treatment experience to provide a reference More >

  • Open Access

    ARTICLE

    The expression and function of miR-376a-3p/DLX axis in gastric cancer cells

    YAN ZHANG, CHAOJUN ZHANG*, ZHEN CAO, ZHANWEI ZHAO, LIN CHEN*

    BIOCELL, Vol.46, No.9, pp. 2073-2080, 2022, DOI:10.32604/biocell.2022.020635

    Abstract Gastric cancer (GC) was referred to a malignant tumor of the digestive tract originating from the epithelium of gastric mucosa. Transcription factor DLX5 was verified as an oncogene in various types of tumors, while miR-376a-3p was speculated as a tumor suppressor. Based on the bioinformatics database, we hypothesized that miR-376a participated in the regulation of GC development by targeting DLX5. Compared with adjacent tissue, a significant increase of DLX5 expression was determined in GC tissues, but the expression level is significantly reduced in miR-376a. Similar expression signature of DLX5 and miR-376a was also determined between… More >

  • Open Access

    ARTICLE

    Arsenic trioxide inhibits the activity of SphK1 by decreasing the level of phosphatidylserine and phosphatidic acid in the human gastric cancer cell line MGC-803

    PEI LIU, ZHE CHEN, XIAOQIONG MA*

    BIOCELL, Vol.46, No.3, pp. 737-743, 2022, DOI:10.32604/biocell.2021.015786

    Abstract Sphingosine kinase 1 (SphK1) is an important synthetase during the synthesis of sphingosine-1-phosphate (S1P) from sphingosine (Sph). Previous studies demonstrated that arsenic trioxide (As2O3) could reduce the level of S1P in human gastric cancer cell line MGC-803, indicating that As2O3 may inhibit the activity of SphK1. In this study, the effect of As2O3 on the SphK1 activation pathway was investigated. Western blot and quantitative real-time PCR analysis were used to evaluate the changes in protein and mRNA levels. The multi-dimensional mass spectrometry-based shotgun lipidomics method (MDMS-SL) was used for the quantitative detection of phosphatidylserine (PS) and phosphatidic… More >

  • Open Access

    ARTICLE

    HAND2-AS1, PRKAA2 and VLDLR predict the risk of peritoneal metastasis in gastric cancer of different Lauren types based on STEPP analysis

    HUI QU1,2,3,4,#, RUICHUAN SHI1,2,3,4,#, BOWEN YANG1,2,3,4, XI CHEN1,2,3,4, YUJIA SONG1,2,3,4, LINGZI HE1,2,3,4, YITING SUN1,2,3,4, YUJING YANG1,2,3,4, ZHI LI1,2,3,4,*, XIUJUAN QU1,2,3,4,*

    BIOCELL, Vol.46, No.3, pp. 721-735, 2022, DOI:10.32604/biocell.2021.015867

    Abstract The peritoneum is the most common site of recurrence of gastric cancer (GC). Early occult peritoneal metastasis is difficult to detect by imaging examination. Stratifying the risk of peritoneal metastasis in patients with different Lauren subtypes is of great clinical value. We performed a univariate Cox regression to identify those genes with prognostic value of overall survival (OS) and peritoneal-specified disease-free survival (psDFS) from the Gene Expression Omnibus database. The candidate genes were screened by the Subpopulation Treatment Effect Pattern Plot (STEPP) method. Propensity score matching (PSM) analysis was used to reduce the interference of… More >

  • Open Access

    ARTICLE

    Construction and validation of prognostic model based on autophagy-related lncRNAs in gastric cancer

    MENGQIU CHENG1,2, WEI CAO2, GUODONG CAO1, XIN XU1,2,*, BO CHEN1,*

    BIOCELL, Vol.46, No.1, pp. 97-109, 2022, DOI:10.32604/biocell.2021.015608

    Abstract Gastric cancer (GC) is one of the most common cancer worldwide. Although emerging evidence indicates that autophagy-related long non-coding RNA (lncRNA) plays an important role in the progression of GC, the prognosis of GC based on autophagy is still deficient. The Cancer Genome of Atlas stomach adenocarcinoma (TCGA-STAD) dataset was downloaded and separated into a training set and a testing set randomly. Then, 24 autophagy-related lncRNAs were found strongly associated with the survival of the TCGA-STAD dataset. 11 lncRNAs were selected to build the risk score model through the least absolute shrinkage and selection operator… More >

  • Open Access

    ARTICLE

    Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to aggravate the malignancy of gastric cancer by upregulating SMAD5

    XUFU QIN1,#, ZIYE JIANG1,#, YONGCUI ZHU1,*, HONGPENG XUE1, CHENGQUN WEI2

    Oncology Research, Vol.29, No.4, pp. 263-273, 2021, DOI:10.32604/or.2022.03568

    Abstract The abnormal expression of long noncoding RNAs (lncRNAs) is frequently observed in gastric cancer (GC) and considered an important driving force in GC progression. However, little is known regarding the involvement of TMEM147-AS1 in GC. Therefore, we examined TMEM147-AS1 expression in GC and determined its prognostic value. In addition, TMEM147-AS1 expression was depleted to identify the functional changes in response to TMEM147-AS1 deficiency. Using the cancer genome atlas dataset and our own cohort, we identified a strong expression of TMEM147-AS1 in GC. Increased TMEM147-AS1 levels in GC showed a significant association with poor prognosis. TMEM147-AS1… More >

  • Open Access

    ARTICLE

    cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells

    BIN LIU1,2,#, HAIPENG LIU3,#, FEIFEI REN1,2, HANGFAN LIU1, IHTISHAM BUKHARI1, YUMING FU4, WANQING WU4, MINGHAI ZHAO5, SHAOGONG ZHU6, HUI MO1, FAZHAN LI1,2, MICHAEL B. ZHENG7, YOUCAI TANG1,2, PENGYUAN ZHENG1,2,*, YANG MI1,2,*

    Oncology Research, Vol.29, No.2, pp. 87-103, 2021, DOI:10.32604/or.2022.03529

    Abstract The activation of some oncogenes promote cancer cell proliferation and growth, facilitate cancer progression and metastasis by induce DNA replication stress, even genome instability. Activation of the cyclic GMP-AMP synthase (cGAS) mediates classical DNA sensing, is involved in genome instability, and is linked to various tumor development or therapy. However, the function of cGAS in gastric cancer remains elusive. In this study, the TCGA database and retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and cell lines. By employing cGAS high-expression gastric cancer cell lines, including AGS and MKN45, ectopic silencing… More >

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