Henry P. Foote¹, Huali Wu², Stephen J. Balevic^1,2, Elizabeth J. Thompson^1,2, Kevin D. Hill^1,2, Eric M. Graham³, Christoph P. Hornik^1,2, Karan R. Kumar^1,2,*

Congenital Heart Disease, Vol.18, No.3, pp. 295-313, 2023, DOI:10.32604/chd.2023.026262

Abstract Background: Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intra-operative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. Methods: We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our institution. We combined real-world dosing data from the electronic health record (EHR) and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration (Cmax) and area under the concentration-time curve for 24 h (AUC24) for MP and the inflammatory cytokines interleukin-6 (IL-6) and interleukin-10 (IL-10). We evaluated the relationships… More > Graphic Abstract

DER-JEU CHEN, CHENG-HUNG LAI^*

BIOCELL, Vol.47, No.6, pp. 1317-1327, 2023, DOI:10.32604/biocell.2023.028883

Abstract Background: Magnolol, a bioactive extract of the Chinese herb Magnolia officinalis has a protective effect against periodontitis. This study is aimed to explore the mechanisms involved in the functioning of magnolol against periodontitis and provide a basis for further research. Methods: Network pharmacology analysis was performed based on the identification of related targets from public databases. The Protein-protein interaction (PPI) network was constructed to visualize the significance between the targets of magnolol and periodontitis. Subsequently, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to predict the functions and the signal regulatory pathways involved in… More >

CHENHAO SHI¹, MAOHONG HUA², GUANHUA XU^3,*

BIOCELL, Vol.47, No.6, pp. 1329-1344, 2023, DOI:10.32604/biocell.2023.028381

Abstract Background: Ulcerative colitis (UC) is a chronic disease that often presents with abdominal pain, diarrhea, hematochezia, and significant morbidity. Gancao Xiexin decoction (GXD), a traditional Chinese medicine, has been applied for the clinical treatment of UC, while its action mechanisms are unclear. Methods: The active ingredients and their targets of GXD, and UC-related targets, were derived from public databases. Protein-protein interaction, Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the important active compounds, key targets, and signaling pathways. Then, molecular docking and animal experiments were performed to verify the findings. A total… More >

Ravikan Nonkhuntod, Suchuan Yu^*

International Journal of Mental Health Promotion, Vol.25, No.5, pp. 613-626, 2023, DOI:10.32604/ijmhp.2023.025648

Abstract Due to peer pressure playing a crucial role in the decision to drink, people who have a more fragile temperament might be expected to be at higher risk. Moreover, many studies have investigated the influence of peer pressure on alcohol consumption, but few have examined the relationship between heavy drinking and peer pressure via a spatial autoregressive model (SAR) in low/middle-income countries, such as Thailand. This paper investigated the connection between heavy drinkers over the age of 15 years who drink more than or equal to 60 grams of unmixed alcohol at least once per month based on the Thai… More >

MAN REN^1,2,3,#, YUAN YANG^1,2,#, DAN LI⁴, NANNAN ZHAO⁵, YUPING WANG^2,6,*, YONGNING ZHOU^2,6,*

BIOCELL, Vol.47, No.5, pp. 977-989, 2023, DOI:10.32604/biocell.2023.028402

Abstract Background: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer activity. Methods: In this study, the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular docking. First, the targets of PGG were searched in the Herbal Ingredients’ Targets (HIT), Similarity Ensemble Approach (SEA), and Super-PRED databases. The potential targets related to gastric cancer were predicted from the Human Gene Database (GeneCards) and DisGeNET databases. The intersecting targets of PGG and gastric cancer were obtained by Venn diagram and then subjected to protein-protein interaction analysis to screen hub targets. Functional and… More >

VIJAY KUMAR^1,#, PRAVEEN C. RAMAMURTHY^2,#, SIMRANJEET SINGH^2,#, DALJEET SINGH DHANJAL³, PARUL PARIHAR⁴, DEEPIKA BHATIA⁵, RAM PRASAD^6,*, JOGINDER SINGH^7,*

BIOCELL, Vol.47, No.5, pp. 1159-1176, 2023, DOI:10.32604/biocell.2023.022065

Abstract Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese Medicines. For several decades, the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, anemia, anorexia, and dyspepsia. In the traditional system, Indian gooseberry has various ethnomedicinal applications. In the Ayurvedic system, different methods of administration (anupan) have shown different ethnomedicinal properties of Indian gooseberry. Seventy well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation, among which the flavonoids and phenols are most prominent. From the toxicity perspective, it is considered a… More >

M. Hari Prabhu^*, K. Sundararaju

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 2947-2958, 2023, DOI:10.32604/iasc.2023.032328

Abstract The power system is facing numerous issues when the distributed generation is added to the existing system. The existing power system has not been planned with flawless power quality control. These restrictions in the power transmission generation system are compensated by the use of devices such as the Static Synchronous Compensator (STATCOM), the Unified Power Quality Conditioner (UPQC) series/shunt compensators, etc. In this work, UPQC’s plan with the joint activity of photovoltaic (PV) exhibits is proposed. The proposed system is made out of series and shunt regulators and PV. A boost converter connects the DC link to the PV source,… More >

K. Naresh Kumar^1,*, S. Srinath²

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 2623-2638, 2023, DOI:10.32604/iasc.2023.031713

Abstract This paper concentrates on compensating the power quality issues which have been increased in day-to-day life due to the enormous usage of loads with power electronic control. One such solution is compensating devices like Pension Protection Fund (PPF), Active power filter (APF), hybrid power filter (HPF), etc., which are used to overcome Power Quality (PQ) issues. The proposed method used here is an active compensator called unified power quality conditioner (UPQC) which is a combination of shunt and series type active filter connected via a common DC link. The primary objective is to investigate the behavior of the compensators in… More >

Yuqian Qi^*, Mingshui Li, Yu Lu, Baitong Li

Energy Engineering, Vol.120, No.5, pp. 1185-1201, 2023, DOI:10.32604/ee.2023.025574

Abstract In view of the problem of power quality degradation of port distribution network after the large-scale application of shore power load, a method of power quality management of port distribution network is proposed. Based on the objective function of the best power quality management effect and the smallest investment cost of the management device, the optimization model of power quality management in the distribution network after the large-scale application of large-capacity shore power is constructed. Based on the balance between the economic demand of distribution network resources optimization and power quality management capability, the power quality of distribution network is… More >

Hui Fang¹, Jingsen Zhou¹, Haozheng Wang^2,*, Yanxu Wang², Hongji Xiang¹, Yechun Xin²

Energy Engineering, Vol.120, No.4, pp. 831-850, 2023, DOI:10.32604/ee.2023.025171

Abstract Recently, high-frequency oscillation of the modular multilevel converter (MMC) based high-voltage direct current (HVDC) projects has attracted great attentions. In order to analyze the small-signal stability, this paper uses the harmonic state-space (HSS) method to establish a detailed frequency domain impedance model of the AC-side of the HVDC transmission system, which considers the internal dynamic characteristics. In addition, the suggested model is also used to assess the system's high-frequency oscillation mechanism, and the effects of the MMC current inner loop control, feedforward voltage links, and control delay on the high-frequency impedance characteristics and the effect of higher harmonic components. Finally,… More >