Qun Song¹, Chao Gao¹, Han Wu¹, Zhiheng Rao¹, Huafeng Qin^1,*, Simon Fong^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-49, 2026, DOI:10.32604/cmc.2025.070918 - 09 December 2025

Abstract Metaheuristic algorithms, renowned for strong global search capabilities, are effective tools for solving complex optimization problems and show substantial potential in e-Health applications. This review provides a systematic overview of recent advancements in metaheuristic algorithms and highlights their applications in e-Health. We selected representative algorithms published between 2019 and 2024, and quantified their influence using an entropy-weighted method based on journal impact factors and citation counts. CThe Harris Hawks Optimizer (HHO) demonstrated the highest early citation impact. The study also examined applications in disease prediction models, clinical decision support, and intelligent health monitoring. Notably, the More >

Himadri Nath Saha¹, Dipanwita Chakraborty Bhattacharya^2,*, Sancharita Dutta³, Arnab Bera³, Srutorshi Basuray⁴, Satyasaran Changdar⁵, Saptarshi Banerjee⁶, Jon Turdiev⁷

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-56, 2026, DOI:10.32604/cmc.2025.070507 - 09 December 2025

Abstract The emergence of Medical Large Language Models has significantly transformed healthcare. Medical Large Language Models (Med-LLMs) serve as transformative tools that enhance clinical practice through applications in decision support, documentation, and diagnostics. This evaluation examines the performance of leading Med-LLMs, including GPT-4Med, Med-PaLM, MEDITRON, PubMedGPT, and MedAlpaca, across diverse medical datasets. It provides graphical comparisons of their effectiveness in distinct healthcare domains. The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making, documentation, drug discovery, research, patient interaction, and public health. The paper addresses deployment challenges of Medical-LLMs, More >

Ning Wang, Haoran Lyu^*, Yuchen Fu

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-31, 2026, DOI:10.32604/cmc.2025.068784 - 10 November 2025

Abstract With the widespread use of social media, the propagation of health-related rumors has become a significant public health threat. Existing methods for detecting health rumors predominantly rely on external knowledge or propagation structures, with only a few recent approaches attempting causal inference; however, these have not yet effectively integrated causal discovery with domain-specific knowledge graphs for detecting health rumors. In this study, we found that the combined use of causal discovery and domain-specific knowledge graphs can effectively identify implicit pseudo-causal logic embedded within texts, holding significant potential for health rumor detection. To this end, we… More >

Ravita Chahar, Ashutosh Kumar Dubey^*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-65, 2026, DOI:10.32604/cmc.2025.066990 - 10 November 2025

Abstract Objective: The increasing global prevalence of mental health disorders highlights the urgent need for the development of innovative diagnostic methods. Conditions such as anxiety, depression, stress, bipolar disorder (BD), and autism spectrum disorder (ASD) frequently arise from the complex interplay of demographic, biological, and socioeconomic factors, resulting in aggravated symptoms. This review investigates machine intelligence approaches for the early detection and prediction of mental health conditions. Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) framework was employed to conduct a systematic review and analysis covering the period 2018 to 2025. The potential… More >

Dakshnamoorthy Manivannan^*

Computer Systems Science and Engineering, Vol.49, pp. 533-555, 2025, DOI:10.32604/csse.2025.072267 - 08 December 2025

Abstract Attribute-based Encryption (ABE) enhances the confidentiality of Electronic Health Records (EHR) (also known as Personal Health Records (PHR)) by binding access rights not to individual identities, but to user attribute sets such as roles, specialties, or certifications. This data-centric cryptographic paradigm enables highly fine-grained, policy-driven access control, minimizing the need for identity management and supporting scalable multi-user scenarios. This paper presents a comprehensive and critical survey of ABE schemes developed specifically for EHR/PHR systems over the past decade. It explores the evolution of these schemes, analyzing their design principles, strengths, limitations, and the level of More >

Lucija Galić, Zdenko Lončarić, Miroslav Lisjak^*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3297-3318, 2025, DOI:10.32604/phyton.2025.072504 - 01 December 2025

Abstract Phenolic compounds represent a broad and structurally diverse class of plant secondary metabolites with importance for both plant biology and human health. This review provides a comprehensive overview of their biosynthesis, chemical diversity, multifaceted functions in plants, roles in the wider ecosystem, and significance in human nutrition and biotechnology. Primarily synthesized via the phenylpropanoid pathway, these compounds encompass major classes such as lignin, flavonoids, and tannins. Within the plant, they perform critical functions including providing structural support (lignin), defending against biotic stresses (e.g., pathogens, herbivores), mediating ecological interactions (pollination, symbiosis, allelopathy), and protecting against abiotic… More >

Yousra Hammouti^1,2,*, François Mesnard², Oussama Khibech³, Mohamed Taibi¹, Yousra Belbachir³, El Hassania Loukili⁴, Reda Bellaouchi⁵, Abdeslam Asehraou⁵, Mohamed Addi^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3563-3583, 2025, DOI:10.32604/phyton.2025.071139 - 01 December 2025

Abstract Centaurium erythraea Rafn (“Gosset El Haya”) has long been prized in North African folk medicine, yet Moroccan chemobiological data remain scarce. Ethanol extracts of northern Moroccan aerial parts were profiled by high-performance liquid chromatography (HPLC) and found rich in phenolics, dominated by 4-hydroxybenzoic acid (57.8%) and naringin (10.3%). The extract exhibited strong antioxidant power in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay, with a half-maximal inhibitory concentration (IC₅₀) of ≈74 µg mL⁻¹, and a total antioxidant capacity (TAC) of ≈201 µg mL⁻¹ and selective antimicrobial activity, sharply inhibiting Aspergillus niger, Penicillium digitatum, and Rhodotorula glutinis while sparing Staphylococcus aureus. In-silico absorption, distribution, metabolism,… More >

Su Li¹, Nooreen Noordin², Dan Wang^3,*

International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1797-1812, 2025, DOI:10.32604/ijmhp.2025.072301 - 28 November 2025

Abstract Background: Communication barriers are a critical yet underexplored determinant of psychological well-being in oncology care, particularly among rural Chinese patients treated in urban hospitals. This study examined how Mandarin proficiency influences emotional distress and identified implications for mental health promotion. Methods: A sequential mixed-methods design was adopted. Quantitative data were collected from 180 rural cancer patients using the Putonghua Proficiency Test (PSC), the Hospital Anxiety and Depression Scale (HADS), and the Distress Thermometer (DT). Multiple linear regressions estimated covariate-adjusted associations between Mandarin proficiency and distress outcomes, controlling for demographic and clinical factors. Semi-structured interviews with 20… More >

Istvan Berkes^1,*, Bettina Piko^2,*

International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1627-1643, 2025, DOI:10.32604/ijmhp.2025.071931 - 28 November 2025

Abstract Objectives: Parentification, a role reversal where children assume age-inappropriate duties in the family, is a significant childhood adversity often linked to disrupted developmental trajectories and poor mental health outcomes. Yet the complexity of parentification, influenced by various contextual factors, obscures a comprehensive understanding of its psychological consequences and its mental health aspects. The paper aims to map up-to-date research, synthesize key findings, and identify critical knowledge gaps. Methods: To that end, a systematic search was performed in Scopus, PsycINFO, PubMed, and EBSCO databases, and data was extracted and reviewed by two reviewers. The search yielded 29… More >

Hyein Jeong¹, Soobin Jang², Bo-Hyoung Jang¹, Chunhoo Cheon¹, Taek Gyu Kim³, Chan Ho Ju³, Hwimun Kim⁴, Su Yong Shin⁵, Kyeong Han Kim^6,*, Seong-Gyu Ko^1,*

International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1695-1708, 2025, DOI:10.32604/ijmhp.2025.071014 - 28 November 2025

Abstract Objectives: This study aimed to evaluate the clinical effectiveness, durability, and acceptability of a Korean medicine-based online mental health self-care program for mothers. Methods: This non-randomized comparative study evaluated the clinical effectiveness, durability, and acceptability of a Korean medicine-based online mental health self-care program for mothers. Group 1 (regular version) included 120 participants who attended one live session per week for 5 weeks, while Group 2 (shortened version) included 30 participants who completed five recorded sessions within 1 week. A total of 112 participants (93.3%) in Group 1 and all 30 participants (100%) in Group 2… More >