Di Qiu^1,3,4, Rongpei Shi^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 1017-1028, 2024, DOI:10.32604/cmes.2024.048797

Abstract For media with inclusions (e.g., precipitates, voids, reinforcements, and others), the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the interfaces. These stress fields depend on the inclusions’ size, shape, and distribution and will respond instantly to the evolving microstructure. This study develops a phase-field model concerning modulus heterogeneity. The effect of modulus heterogeneity on the growth process and equilibrium state of the α plate in Ti-6Al-4V during precipitation is evaluated. The α precipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial… More >

Tianyi Li^1,2, Xin Gu², Qing Zhang^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 339-361, 2024, DOI:10.32604/cmes.2024.047566

Abstract This study proposes a comprehensive, coupled thermomechanical model that replaces local spatial derivatives in classical differential thermomechanical equations with nonlocal integral forms derived from the peridynamic differential operator (PDDO), eliminating the need for calibration procedures. The model employs a multi-rate explicit time integration scheme to handle varying time scales in multi-physics systems. Through simulations conducted on granite and ceramic materials, this model demonstrates its effectiveness. It successfully simulates thermal damage behavior in granite arising from incompatible mineral expansion and accurately calculates thermal crack propagation in ceramic slabs during quenching. To account for material heterogeneity, the model utilizes the Shuffle algorithm… More >

Dengke Xu¹, Linlin Shen¹, Fangzhong Xu^2,*

International Journal of Mental Health Promotion, Vol.26, No.3, pp. 229-238, 2024, DOI:10.32604/ijmhp.2024.046023

Abstract Based on China Family Panel Studies (CFPS) 2018 data, the multiple linear regression model is used to analyze the effects of Internet use on women’s depression, and to test the robustness of the regression results. At the same time, the effects of Internet use on mental health of women with different residence, age, marital status and physical health status are analyzed. Then, we can obtain that Internet use has a significant promoting effect on women’s mental health, while the degree of Internet use has a significant inhibitory effect on women’s mental health. In addition, the study found that women’s age,… More >

REZA YADOLLAHVANDMIANDOAB^1,#, MEHRSA JALALIZADEH^1,#, FRANCIELE APARECIDA VECHIA DIONATO¹, KEINI BUOSI¹, PATRÍCIA A. F. LEME¹, LUCIANA S. B. DAL COL¹, CRISTIANE F. GIACOMELLI¹, ALEX DIAS ASSIS¹, NASIM BASHIRICHELKASARI¹, LEONARDO OLIVEIRA REIS^1,2,*

Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442

Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed that this technology can identify… More > Graphic Abstract

HAO LV¹, BO ZHU^1,2, DEGAO CHEN^1,2,*

BIOCELL, Vol.48, No.3, pp. 363-378, 2024, DOI:10.32604/biocell.2023.046367

Abstract Tumor-associated macrophages (TAMs) are emerging as targets for tumor therapy because of their primary role in promoting tumor progression. Several studies have been conducted to target TAMs by reducing their infiltration, depleting their numbers, and reversing their phenotypes to suppress tumor progression, leading to the development of drugs in preclinical and clinical trials. However, the heterogeneous characteristics of TAMs, including their ontogenetic and functional heterogeneity, limit their targeting. Therefore, in-depth exploration of the heterogeneity of TAMs, combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor treatment. This review focuses on the heterogeneous ontogeny and… More >

Frantisek Kavicka^a,*, Jana Dobrovska^b, Karel Stransky^a, Bohumil Sekanina^a, Josef Stetina^a

Frontiers in Heat and Mass Transfer, Vol.3, No.2, pp. 1-9, 2012, DOI:10.5098/hmt.v3.2.3002

Abstract Corundo-baddeleyit material (CBM) – EUCOR – is a heat- and wear-resistant material even at extreme temperatures. This article introduces an original numerical model of solidification and cooling of this material in a non-metallic mold. The second, cooperating model of chemical heterogeneity and its application on EUCOR samples prove that the applied method of measuring the chemical heterogeneity provides the detailed quantitative information on the material structure and makes it possible to analyze the solidification process. The verification of both numerical models was conducted on a real cast 350 x 200 x 400 mm block. More >

Shuyu Wang¹, Linjuan Wang^1,*, Yunteng Wang²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09217

Abstract Material heterogeneity plays an important role in the blasting induced rock fracture. However, the investigation of the effects of material heterogeneity is limited by the numerical methods for dynamic fracture. In the work, we propose a peridynamic model for brittle rock with heterogeneous micro-modulus and critical stretch to investigate the effects of material heterogeneity on the blast-induced rock crack initiation and propagation. The discretization in polar coordinates is introduced into the proposed model to avoid the fallacious directional guidance to the crack initiation around the hole. The proposed model satisfies the More >

JINHUI LIU^1,*, JIAHENG XIE^2,*, PEIXIN DONG³

Oncology Research, Vol.32, No.1, pp. 99-100, 2024, DOI:10.32604/or.2023.045719

Abstract This article has no abstract. More >

Jiangxia Han^1,2, Liang Xue^1,2,*, Ying Jia³, Mpoki Sam Mwasamwasa^1,2, Felix Nanguka⁴, Charles Sangweni⁵, Hailong Liu³, Qian Li³

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1323-1340, 2024, DOI:10.32604/cmes.2023.031093

Abstract Recent advances in deep neural networks have shed new light on physics, engineering, and scientific computing. Reconciling the data-centered viewpoint with physical simulation is one of the research hotspots. The physics-informed neural network (PINN) is currently the most general framework, which is more popular due to the convenience of constructing NNs and excellent generalization ability. The automatic differentiation (AD)-based PINN model is suitable for the homogeneous scientific problem; however, it is unclear how AD can enforce flux continuity across boundaries between cells of different properties where spatial heterogeneity is represented by grid cells with different physical properties. In this work,… More >

DONGYE YANG^1,#,*, DONGDONG GUO^2,3,#, YUNMEI PENG², DONGMENG LIU¹, YANQIU FU¹, FEN SUN², LISHI ZHOU¹, JIAQI GUO¹, LAIQING HUANG^2,3,*

BIOCELL, Vol.47, No.9, pp. 2037-2049, 2023, DOI:10.32604/biocell.2023.028863

Abstract Introduction: Sulfatase 2 (SULF2), an endogenous extracellular sulfatase, can remove 6-O-sulfate groups of glucosamine residues from heparan sulfate (HS) chains to modulate the Wnt/β-catenin signaling pathway, which plays an important role in both liver carcinogenesis and embryogenesis. Side population (SP) cells are widely identified as stem-like cancer cells and are closely related to carcinoma metastasis, recurrence, and poor patient prognosis. However, the roles of SULF2 in SP cells of hepatomas are unclear, and the underlying mechanism is undefined. Objectives: This study aimed to compare the heterogeneity between SP cells and non-side population (NSP) cells derived from three different liver cancer… More > Graphic Abstract