Roland Mangold, Timea Teglas^*

BIOCELL, Vol.49, No.12, pp. 2239-2244, 2025, DOI:10.32604/biocell.2025.069925 - 24 December 2025

Abstract The quality of life in older adulthood is greatly influenced by cognitive aging, which in turn is affected by nutrition, especially as it relates to hippocampal function. Although the link between hippocampal function and nutrition is defined, the exact mechanics are still unknown. The commentary addresses how docosahexaenoic acid (DHA) contributes to age-related cognitive decline and may play a role in promoting neurogenesis and neuroplasticity on the molecular level. The current challenge to our understanding is to investigate how DHA influences hippocampal function and cognitive aging, which would be possible and even more detailed with More >

Myoung Cheol Shin¹, Tae-Kyeong Lee², Dae Won Kim³, Joon Ha Park⁴, Moo-Ho Won¹, Choong-Hyun Lee^5,*, Ji Hyeon Ahn^6,*

BIOCELL, Vol.49, No.6, pp. 1071-1083, 2025, DOI:10.32604/biocell.2025.065506 - 24 June 2025

Abstract Background: Astrocyte endfeet (AEF) serves as a key element of the blood-brain barrier and is important for the survival and maintenance of neuronal function. However, the immunohistochemical and ultrastructural changes of AEF in the CA1 and CA3 areas of the hippocampus over time following cerebral ischemia-reperfusion (IR) injury have not been well elucidated. Objectives: We investigated chronological changes in AEF in the gerbil hippocampal CA1 area from 3 h to 10 days following transient forebrain ischemia (TFI), and examined their association with neuronal death and tissue repair following IR injury. Changes in the CA3 area… More >

Xinyi Xiao, Dongbo Pan^*, Jianjun Yuan

Intelligent Automation & Soft Computing, Vol.37, No.3, pp. 3179-3191, 2023, DOI:10.32604/iasc.2023.041208 - 11 September 2023

Abstract Neurological disorders like Alzheimer’s disease have a significant impact on the lives and health of the elderly as the aging population continues to grow. Doctors can achieve effective prevention and treatment of Alzheimer’s disease according to the morphological volume of hippocampus. General segmentation techniques frequently fail to produce satisfactory results due to hippocampus’s small size, complex structure, and fuzzy edges. We develop a new SC-Net model using complete brain MRI images to achieve high-precision segmentation of hippocampal structures. The proposed network improves the accuracy of hippocampal structural segmentation by retaining the original location information of More >

Naigong Yu^*, Hejie Yu

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.2, pp. 1147-1169, 2022, DOI:10.32604/cmes.2022.019430 - 14 March 2022

Abstract The entorhinal-hippocampus structure in the mammalian brain is the core area for realizing spatial cognition. However, the visual perception and loop detection methods in the current biomimetic robot navigation model still rely on traditional visual SLAM schemes and lack the process of exploring and applying biological visual methods. Based on this, we propose a map construction method that mimics the entorhinal-hippocampal cognitive mechanism of the rat brain according to the response of entorhinal cortex neurons to eye saccades in recent related studies. That is, when mammals are free to watch the scene, the entorhinal cortex… More >