Pei-Yu Kao¹, Jie-Hong Chen², Kuo-Hu Chen^1,3,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078219 - 21 May 2026

Abstract Cervical cancer remains a major global health challenge despite advances in human papillomavirus (HPV) vaccination, screening, and treatment. Persistent infection with high-risk HPV types, particularly HPV16 and HPV18, is a necessary cause of cervical cancer; however, only a small fraction of infections progress to malignancy, indicating the importance of additional cofactors. Increasing evidence identifies estrogen signaling as a critical modifier of HPV-driven carcinogenesis. Estrogen acts synergistically with HPV oncogenes E6 and E7 to promote genomic instability, immune evasion, and tumor progression, largely through effects on the tumor microenvironment (TME). This review aims to clarify and… More >

Cuifang Chang, Hua Fang, Xinfang Chen, Zhongfeng Yao, Yali Zhu, Caicai Ma, Qi Wang, Weibiao Liao^*

Phyton-International Journal of Experimental Botany, Vol.95, No.4, 2026, DOI:10.32604/phyton.2026.077290 - 28 April 2026

Abstract The cinnamoyl-CoA reductase (CCR) gene family plays a pivotal role in lignin biosynthesis and plant stress adaptation by catalyzing the first committed step in the monolignol-specific branch of the phenylpropanoid pathway. However, a comprehensive and systematic analysis of CCRs in the economically important Rosa genus remains lacking. Here, we conducted a systematic genome-wide investigation of CCR genes in a diploid species, Rosa chinensis, and a tetraploid cultivar, Rosa × hybrida. We identified 15 and 36 non-redundant CCR genes in R. chinensis and R. × hybrida, respectively. From these, we selected 14 high-confidence orthologs of RcCCR in the R. × hybrida genome as a core… More >

Luigi Coltelli^1,2,#, Paola Orlandi^3,#, Chiara Finale^1,4,#, Gianna Musettini^1,4,#, Luna Chiara Masini^1,4, Marco Scalese⁵, Giulia Soria^1,4, Elena Sartori^1,4, Ylenia Nodari^1,4, Giada Arrighi^1,2, Arianna Bandini³, Marta Banchi³, Costanza Tacchi³, Donghao Tang³, Barbara Salvadori⁶, Lucia Tanganelli^1,7, Simona Giovannelli^1,8, Mirco Pistelli⁹, Samanta Cupini^1,4, Maurizio Lucchesi^1,10, Alessandro Cosimi¹¹, Giulia Lorenzini^1,7, Elisa Biasco^1,4, Chiara Caparello^1,4, Giulia Acconci^1,4,6, Eloise Fontana^1,4, Eleonora Bona^1,4, Azzurra Farnesi^1,4, Antonio Pellino^1,4, Andrea Marini^1,4, Ermelinda De Maio^1,4, Irene Stasi^1,4, Cecilia Barbara^1,4, Enrico Sammarco^1,4, Javier Rosada^12,13, Giacomo Allegrini^1,4,*, Guido Bocci^3,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.073799 - 22 April 2026

Abstract Background: The treatment of advanced hormone receptor-positive (HR+) breast cancer has seen relevant changes in last years. However, bevacizumab remains an option when combined with paclitaxel, but no certified pharmacogenetic profiles are now usable for the prediction of its response in breast cancer patients. This study aimed to explore the pharmacogenetic interactions among single nucleotide polymorphisms (SNPs) of genes involved in the angiogenic process and their impact on progression-free survival (PFS) and overall survival (OS) in hormone receptor-positive (HR+) metastatic breast cancer subjects administered with bevacizumab plus paclitaxel, or with paclitaxel alone (clinicaltrial.gov… More >

Peng Xian^1,2,#, Zhenwei Feng^1,3,#, Haitao Yu³, Hubin Yin^1,3, Haonan Chen¹, Tenglin Shi¹, Xilai Li^1,3, Chunlin Zhang^1,3, Xuesong Bai^1,3, Xin Gou^1,*, Xinyuan Li^1,3,*, Jie Li^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073156 - 23 March 2026

Abstract Objective: Androgen receptor (AR) signaling is a central driver of prostate cancer progression, yet the metabolic and transcriptional mechanisms regulating AR expression remain incompletely characterized. This study investigated whether the immunoproteasome inhibitor ONX-0914 suppresses hormone-sensitive prostate cancer (HSPC) through metabolic modulation of AR and aimed to identify the transcriptional mediator involved. Methods: HSPC and castration-resistant prostate cancer models were used to evaluate the effects of ONX-0914 on cell proliferation, invasion, migration, and epithelial–mesenchymal transition. Xenograft assays, bioinformatic screening, and analyses of O-GlcNAcylation and protein stability were performed, together with quantitative polymerase chain reaction (qPCR) and… More >

Keiko Yanagihara^1,*, Masato Yoshida², Kensaku Awaji², Tamami Yamakawa¹, Sena Kato¹, Miki Tamura¹, Koji Nagata³

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.073891 - 30 December 2025

Abstract Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have transformed the management of hormone receptor–positive/HER2–negative (HR+/HER2–) advanced breast cancer, yet evidence for elderly or poor-performance patients remains limited. This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients, with additional subgroup analyses by age and performance status. Methods: We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2− breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), disease control rate (DCR), and safety.… More >

Totan Kumar Ghosh¹, Md. Roushonuzzaman Rakib¹, Munna¹, S. M. Zubair AL-Meraj¹, Md. Moshiul Islam², Anika Nazran¹, Mohammad Golam Mostofa^3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3925-3943, 2025, DOI:10.32604/phyton.2025.073382 - 29 December 2025

Abstract The productivity of common bean (Phaseolus vulgaris L.), an economically important legume, is severely hindered by drought stress. While melatonin (Mel) and methyl jasmonate (MeJA) are known to alleviate abiotic stresses, their combined effects in mitigating drought-induced oxidative stress are unknown. Here, we examined the synergistic effects of Mel and MeJA in alleviating drought-associated oxidative damage in common bean. Compared with well-watered controls, drought stress caused a significant decline in plant biomass, photosynthetic pigments, and photosystem II efficiency (F_v/F_m). Drought also significantly increased hydrogen peroxide (H₂O₂) accumulation, which likely contributed to membrane lipid peroxidation, as indicated by… More >

Xiaoqin Zheng¹, Yuqing Wan¹, Qian Zhang², Liqin He², Shihao Tang¹, Qiguo Zhuang², Lihua Wang^2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3879-3892, 2025, DOI:10.32604/phyton.2025.073229 - 29 December 2025

Abstract To investigate endogenous hormone changes in “Hongyang” kiwifruit from overwintering buds to floral morphogenesis (bell-shaped flowering stage), systematic observations were conducted during the undifferentiated stage, axillary bud differentiation stage, and floral morphogenesis stage from late November 2023 to early April 2024. Paraffin sectioning was employed to examine floral bud morphology, while LC-MS targeted metabolomics quantified changes in 15 endogenous hormones across 8 classes. Results indicated floral bud differentiation commenced from late January to early February and concluded by mid-April, spanning approximately 70 days. Approximately 33 days after axillary bud initiation marked the axillary bud primordium… More >

Anushka Ghosh, Maria J. D’Amico, Yash B. Shah, Whitney R. Smith, Mihir S. Shah, Costas D. Lallas, Alana M. Murphy^*

Canadian Journal of Urology, Vol.32, No.6, pp. 627-632, 2025, DOI:10.32604/cju.2025.067575 - 30 December 2025

Abstract Background: Genitourinary syndrome of menopause (GSM) is a highly prevalent, underdiagnosed condition that can significantly impair quality of life (QoL). This study evaluates real-world treatment trends for GSM to better understand current management practices and highlight ongoing gaps in care. The background is in a different font than the rest of the abstract. Methods: We queried the TriNetX database for patients with a diagnosis of postmenopausal atrophic vaginitis (ICD N95.2) and treatment information from 2004–2024. A combination of RxNorm and International Classification of Diseases-10 (ICD) codes was used to classify disease and treatment type, including… More >

Taras Shatylko^1,*, Ruslan Safiullin¹, Safar Gamidov^1,2, Tatiana Ivanets¹, Ramazan Mammaev², Kanan Guluzade², Ilia Rodin³, Gennadiy Sukhikh¹

Canadian Journal of Urology, Vol.32, No.6, pp. 561-568, 2025, DOI:10.32604/cju.2025.064572 - 30 December 2025

Abstract Background: Some patients with prostate cancer have elevated gonadotropin levels. It is unknown, however, whether this condition directly influences carcinogenesis in the prostate. It is also unknown whether any specific hormone levels are useful to predict aggressive disease. The potential role of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in prostate physiology is widely discussed. The study aimed to evaluate whether patients with this endocrine pattern have different outcomes following radical prostatectomy. Methods: This was a prospective cohort study of consecutive patients undergoing robot-assisted radical prostatectomy at the Andrology and Urology Department, National Medical Research… More >

Hongjuan Xu¹, Lan Yang¹, Lejuan Shi¹, Weize Wang¹, Yiwen Guan¹, Ye Liu¹, Panpan Yang^2,3,*, Zhilin Chen^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3157-3173, 2025, DOI:10.32604/phyton.2025.071147 - 29 October 2025

Abstract Vivipary in plants evolved under long-term adaptation to harsh environments and is an important reproduction pathway. However, the mechanisms driving vegetative vivipary are still unclear. In this study, we investigated the anatomy of viviparous inflorescences of Festuca glauca ‘Elijah Blue’ using stereomicroscopy and paraffin section anatomical observation. We also determined the contents of endogenous hormones in normal and viviparous inflorescences using an enzyme-linked immunosorbent assay. In viviparous inflorescences, typical upper and lower epidermal tissues, spongy tissue, and palisade tissue of leaves appeared in developmental stages 2 and 3 (20 and 45 days after emergence), indicating vegetative… More >