Takeo Matsumoto^1,*, Chizuru Hirooka¹, Yong Fan¹, Junfeng Wang¹, Naoki Mori¹, Eijiro Maeda¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 81-81, 2019, DOI:10.32604/mcb.2019.07102

Abstract Aortic wall thickens in response to hypertension. Many studies reported that the wall thickening occurs to maintain the wall stress in the circumferential direction at a constant level. In case of the longitudinal direction, however, there are few studies suggesting the constancy of the stress. Such anisotropic response may be attributable to the circumferential alignment of the smooth muscle cells (SMCs) in the wall [1]. However, to the authors’ knowledge, there are no study discussing the underlying mechanism of the anisotropic response. It has been reported that mechanical deformation of the nuclei causes transcription upregulation [2]. This might suggest that… More >

Fuyou Liang^1,*, Tianqi Wang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 25-26, 2019, DOI:10.32604/mcb.2019.05710

Abstract Hepatic venous pressure gradient (HVPG) measurement has been increasingly accepted as a useful means for indirectly measuring portal venous pressure in patients with portal hypertension (PHT) caused by chronic liver diseases. Despite the existence of numerous studies addressing the clinical utility of HVPG measurement, it is as yet unclear how the accuracy of measured HVPG as a surrogate of portal pressure gradient (PPG) is influenced by the pathological status of the hepatic circulation that not only changes with the progression of liver disease but also differs considerably among patients. In addition, it remains unclear whether HVPGs measured in different hepatic… More >

M. Cruzado, C. Castro, N. Risler, R. Miatello

BIOCELL, Vol.26, No.1, pp. 61-67, 2002, DOI:10.32604/biocell.2002.26.061

Abstract Nitric oxide (NO) generation by inducible nitric oxide synthase (iNOS) in the vascular smooth muscle cells (VSMC), may play a role in blood vessel tone regulation. Lipopolysaccharide (LPS) induced iNOS activity and subsequent nitrite production by cultured aortic VSMC, from SHR with an established chronic blood pressure elevation (adult SHR) or during the period preceding the development of hypertension (young SHR) and from age-matched normotensive Wistar (W) rats were compared. Angiotensin II (Ang II) effect was also evaluated. Both basal LPS-induced iNOS activity and nitrite accumulation were significantly lower in young SHR VSMC compared to young W rat cells. In… More >

Longling Fan^1,*, Jing Yao ^{2, *}, Chun Yang³, Di Xu², Dalin Tang^{1, 4, §}

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 221-237, 2018, DOI:10.3970/cmes.2018.114.221

Abstract Understanding cardiac blood flow behaviors is of importance for cardiovascular research and clinical assessment of ventricle functions. Patient-specific Echo-based left ventricle (LV) fluid-structure interaction (FSI) models were introduced to perform ventricle mechanical analysis, investigate flow behaviors, and evaluate the impact of myocardial infarction (MI) and hypertension on blood flow in the LV. Echo image data were acquired from 3 patients with consent obtained: one healthy volunteer (P1), one hypertension patient (P2), and one patient who had an inferior and posterior myocardial infarction (P3). The nonlinear Mooney-Rivlin model was used for ventricle tissue with material parameter values chosen to match echo-measure… More >

Wei Huang^∗,†, Yi Wah Mak^*, Peter C. Y. Chen^‡§

Molecular & Cellular Biomechanics, Vol.8, No.2, pp. 91-104, 2011, DOI:10.3970/mcb.2011.008.091

Abstract A molecular configuration tensor Pij was introduced to analyze the distribution of fibrous proteins in vascular cells for studying cells and tissues biomechanics. We have used this technique to study the biomechanics of vascular remodeling in response to the changes of blood pressure and flow. In this paper, the remodeling of the geometrical arrangement of F-actin fibers in the smooth muscle cells in rat's pulmonary arteries in hypoxic hypertension was studied. The rats were exposed to a hypoxia condition of 10% for 0, 2, 12, and 24 hr at sea level. Remodeling of blood vessels were studied at the in… More >