Bo Wu1,#, Huacai Xiong2,#, Yong Wang1, Shankun Zhao1, Hongsheng Lu1, Wei Hu3,*
Oncologie, Vol.24, No.3, pp. 553-563, 2022, DOI:10.32604/oncologie.2022.023025
Abstract Epidermal growth factor receptor (EGFR) is frequently overexpressed in multiple malignancies. Icotinib (IH), a
new EGFR tyrosine kinase inhibitor, enhances radiosensitivity in various types of cancer, but its effect on nasopharyngeal carcinoma (NPC) remains unclear. Total 115 NPC tissue sections and 30 nasopharyngitis tissue sections were enrolled. The correlation of EGFR expression and clinicopathologic features of NPC was analyzed.
Survival analysis was calculated by using univariate and multivariate regression analysis. A radioresistant NPC
cell line, CNE-2R, was established with a gradient irradiation schedule. Cell viability, colony formation and EGFR
expression of CNE-2/2R cells were examined. Significant higher expression of EGFR… More >
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