JINGWEI JIANG1,2, BO JIA3, CHUAN WANG3, CHEN FANG1, YUGUI LI1, GUOXING LING1, BAOSHI ZHENG1,*, CHENG LUO1,*
BIOCELL, Vol.49, No.1, pp. 61-78, 2025, DOI:10.32604/biocell.2024.056981
- 24 January 2025
Abstract The role and regulatory mechanisms of macrophage polarization in cardiac transplantation have gained significant attention. Macrophages can polarize into either the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype in response to environmental cues. M1 macrophages facilitate transplant rejection by releasing inflammatory mediators and activating T cells, whereas M2 macrophages support graft survival by secreting anti-inflammatory factors and promoting tissue repair. Mitochondrial quality control regulation plays a crucial role in macrophage polarization, which may influence graft survival and immune responses. This review provides an overview of the current understanding of mitochondrial quality control-regulated macrophage polarization in cardiac More >
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