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  • Open Access


    Influence of non-Newtonian Properties of Blood on the Wall Shear Stress in Human Atherosclerotic Right Coronary Arteries

    Biyue Liu, Dalin Tang

    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 73-90, 2011, DOI:10.3970/mcb.2011.008.073

    Abstract The objective of this work is to investigate the effect of non-Newtonian properties of blood on the wall shear stress (WSS) in atherosclerotic coronary arteries using both Newtonian and non-Newtonian models. Numerical simulations were performed to examine how the spatial and temporal WSS distributions are influenced by the stenosis size, blood viscosity, and flow rate. The computational results demonstrated that blood viscosity properties had considerable effect on the magnitude of the WSS, especially where disturbed flow was observed. The WSS distribution is highly non-uniform both temporally and spatially, especially in the stenotic region. The maximum WSS occurred at the proximal… More >

  • Open Access


    Influence of Arterial Wall Compliance on the Pressure Drop across Coronary Artery Stenoses under Hyperemic Flow Condition

    Bhaskar Chandra Konala, Ashish Das, Rupak K Banerjee∗,†

    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 1-20, 2011, DOI:10.3970/mcb.2011.008.001

    Abstract Hemodynamic endpoints such as flow and pressure drop are often measured during angioplasty procedures to determine the functional severity of a coronary artery stenosis. There is a lack of knowledge regarding the influence of compliance of the arterial wall-stenosis on the pressure drop under hyperemic flows across coronary lesions. This study evaluates the influence in flow and pressure drop caused by variation in arterial-stenosis compliance for a wide range of stenosis severities. The flow and pressure drop were evaluated for three different severities of stenosis and tested for limiting scenarios of compliant models. The Mooney-Rivlin model defined the non-linear material… More >

  • Open Access


    Geometric Confinement Influences Cellular Mechanical Properties II -- Intracellular Variances in Polarized Cells

    Judith Su, Ricardo R. Brau, Xingyu Jiang, George M. Whitesides§, Matthew J. Lang, Peter T. C. So||

    Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 105-118, 2007, DOI:10.3970/mcb.2007.004.105

    Abstract During migration, asymmetrically polarized cells achieve motion by coordinating the protrusion and retraction of their leading and trailing edges, respectively. Although it is well known that local changes in the dynamics of actin cytoskeleton remodeling drive these processes, neither the cytoskeletal rheological properties of these migrating cells are well quantified nor is it understand how these rheological properties are regulated by underlying molecular processes. In this report, we have used soft lithography to create morphologically polarized cells in order to examine rheological differences between the front and rear zone of an NIH 3T3 cell posed for migration. In addition, we… More >

  • Open Access


    Geometric Confinement Influences Cellular Mechanical Properties I -- Adhesion Area Dependence

    Judith Su, Xingyu Jiang, Roy Welsch, George M. Whitesides§, Peter T. C. So

    Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 87-104, 2007, DOI:10.3970/mcb.2007.004.087

    Abstract Interactions between the cell and the extracellular matrix regulate a variety of cellular properties and functions, including cellular rheology. In the present study of cellular adhesion, area was controlled by confining NIH 3T3 fibroblast cells to circular micropatterned islands of defined size. The shear moduli of cells adhering to islands of well defined geometry, as measured by magnetic microrheometry, was found to have a significantly lower variance than those of cells allowed to spread on unpatterned surfaces. We observe that the area of cellular adhesion influences shear modulus. Rheological measurements further indicate that cellular shear modulus is a biphasic function… More >

  • Open Access


    Knowledge Composition and Its Influence on New Product Development Performance in the Big Data Environment

    Chuanrong Wu1,*, Veronika Lee1, Mark E. McMurtrey2

    CMC-Computers, Materials & Continua, Vol.60, No.1, pp. 365-378, 2019, DOI:10.32604/cmc.2019.06949

    Abstract Product innovation is regarded as a primary means for enterprises to maintain their competitive advantage. Knowledge transfer is a major way that enterprises access knowledge from the external environment for new product innovation. Knowledge transfer may face the risk of infringement of the intellectual property rights of other enterprises and the termination of licensing agreements by the knowledge source. Enterprises must develop independent innovation knowledge at the same time they profit from knowledge transfers. Therefore, new product development by an enterprise usually consists of three types of new knowledge: big data knowledge transferred from big data knowledge providers, private knowledge… More >

  • Open Access


    An Influence Maximization Algorithm Based on the Mixed Importance of Nodes

    Yong Hua1, Bolun Chen1,2,*, Yan Yuan1, Guochang Zhu1, Jialin Ma1

    CMC-Computers, Materials & Continua, Vol.59, No.2, pp. 517-531, 2019, DOI:10.32604/cmc.2019.05278

    Abstract The influence maximization is the problem of finding k seed nodes that maximize the scope of influence in a social network. Therefore, the comprehensive influence of node needs to be considered, when we choose the most influential node set consisted of k seed nodes. On account of the traditional methods used to measure the influence of nodes, such as degree centrality, betweenness centrality and closeness centrality, consider only a single aspect of the influence of node, so the influence measured by traditional methods mentioned above of node is not accurate. In this paper, we obtain the following result through experimental… More >

  • Open Access


    A Loose Coupling Multiscale Approach for the Detailed Analysis of the Influence of Critical Areas on the Global Behaviour of Composite Structures

    D. Chrupalla1, J. Kreikemeier1, S. Berg2, L. Kärger3, M. Doreille4, T. Ludwig4, E. Jansen2, R. Rolfes2, A.Kling1

    CMC-Computers, Materials & Continua, Vol.32, No.3, pp. 159-176, 2012, DOI:10.3970/cmc.2012.032.159

    Abstract In this paper, a loose coupling multiscale modeling technique for the detailed numerical analysis of critical areas in composite structures is presented. It is used to describe the global (macroscopic) behaviour of composite structures taking into account the effects of local phenomena. This is done by indirectly connecting the global and local FE-models. Prescribed displacements are assigned to the local boundaries in the transition from the global to local modeling level. The local-to-global transition is realized by assigning averaged local stresses to the respective global Gauss points and by updating the global tangent stiffness operator. To illustrate the feasibility of… More >

  • Open Access


    The Influence of Third Order Elastic Constants on Axisymmetric Wave Propagation Velocity in the Two-Layered Pre-Stressed Hollow Cylinder

    S.D. Akbarov1,2

    CMC-Computers, Materials & Continua, Vol.32, No.1, pp. 29-60, 2012, DOI:10.3970/cmc.2012.032.029

    Abstract By the use of the Murnaghan potential the influence of third order elastic constants on axisymmetric longitudinal wave propagation velocity in a pre-stressed two-layered circular hollow cylinder is investigated. This investigation is carried out within the scope of the piecewise homogeneous body model by utilizing the first version of the small initial deformation theory of the Three-dimensional Linearized Theory of Elastic Waves in Initially Stressed Bodies. Numerical results are obtained and analyzed for the cases where the material of the outer hollow cylinder material is aluminum, but the material of the inner cylinder is steel (Case 1) and tungsten (Case… More >

  • Open Access


    Influence of Geometric Design Variable and Bone Quality on Stress Distribution for Zirconia Dental Implants-A 3D Finite Element Analysis

    Duraisamy Velmurugan1, Masilamany Santha Alphin1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.2, pp. 125-141, 2018, DOI:10.31614/cmes.2018.01817

    Abstract This study aims to investigate the effects of variable thread pitch on stress distribution in bones of different bone qualities under two different loading conditions (Vertical, and Horizontal) for a Zirconia dental implant. For this purpose, a three dimensional finite element model of the mandibular premolar section and three single threaded implants of 0.8 mm, 1.6 mm, 2.4 mm pitch was designed. Finite element analysis software was used to develop the model and three different bone qualities (Type II, Type III, and Type IV) were prepared. A vertical load of 200 N, and a horizontal load of 100 N was… More >

  • Open Access


    Deformation and failure analysis of river levee induced by coal mining and its influence factor

    Meng Li1,2, Jixiong Zhang1,3, Nan Zhou1, Qiang Zhang1

    CMES-Computer Modeling in Engineering & Sciences, Vol.113, No.2, pp. 183-194, 2017, DOI:10.3970/cmes.2017.113.189

    Abstract To study the influence of coal mining on the stability of river levees, a mechanical model of mining-induced river levee deformation was established. This was based on the mining-induced deformation characteristics of river levees and the application of a typical surface subsidence function. Meanwhile, a failure criterion was proposed for river levees. Using some examples, the deformation of, and stress distribution through, river levees under the influence of mining were obtained: the maximum tensile stress on the bottom of the river levee was less than the tensile strength, under which circumstance the river levee remained undamaged. Meanwhile, this research analyzed… More >

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