Bo Li, Jie Jia^*, Peiwen Tan, Xinyan Chen, Dongjin Li

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.071186 - 12 January 2026

Abstract Medical image segmentation is of critical importance in the domain of contemporary medical imaging. However, U-Net and its variants exhibit limitations in capturing complex nonlinear patterns and global contextual information. Although the subsequent U-KAN model enhances nonlinear representation capabilities, it still faces challenges such as gradient vanishing during deep network training and spatial detail loss during feature downsampling, resulting in insufficient segmentation accuracy for edge structures and minute lesions. To address these challenges, this paper proposes the RE-UKAN model, which innovatively improves upon U-KAN. Firstly, a residual network is introduced into the encoder to effectively… More >

Chee Chin Lim^1,2,*, Hui Wen Tiu¹, Qi Wei Oung^1,3, Chiew Chea Lau⁴, Xiao Jian Tan^2,5

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.070468 - 12 January 2026

Abstract Breast cancer remains one of the leading causes of cancer mortality world-wide, with accurate molecular subtyping is critical for guiding treatment and improving patient outcomes. Traditional molecular subtyping via immuno-histochemistry (IHC) test is invasive, time-consuming, and may not fully represent tumor heterogeneity. This study proposes a non-invasive approach using digital mammography images and deep learning algorithm for classifying breast cancer molecular subtypes. Four pretrained models, including two Convolutional Neural Networks (MobileNet_V3_Large and VGG-16) and two Vision Transformers (ViT_B_16 and ViT_Base_Patch16_Clip_224) were fine-tuned to classify images into HER2-enriched, Luminal, Normal-like, and Triple Negative subtypes. Hyperparameter tuning,… More >

Ahsan Habib Siam¹, Md. Ehsanul Haque¹, Fahmid Al Farid², Anindita Sutradhar³, Jia Uddin^4,*, Sarina Mansor^2,*

CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.069718 - 12 January 2026

Abstract As healthcare systems increasingly embrace digitalization, effective management of electronic health records (EHRs) has emerged as a critical priority, particularly in inpatient settings where data sensitivity and real-time access are paramount. Traditional EHR systems face significant challenges, including unauthorized access, data breaches, and inefficiencies in tracking follow-up appointments, which heighten the risk of misdiagnosis and medication errors. To address these issues, this research proposes a hybrid blockchain-based solution for securely managing EHRs, specifically designed as a framework for tracking inpatient follow-ups. By integrating QR code-enabled data access with a blockchain architecture, this innovative approach enhances… More >

Qun Song¹, Chao Gao¹, Han Wu¹, Zhiheng Rao¹, Huafeng Qin^1,*, Simon Fong^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-49, 2026, DOI:10.32604/cmc.2025.070918 - 09 December 2025

Abstract Metaheuristic algorithms, renowned for strong global search capabilities, are effective tools for solving complex optimization problems and show substantial potential in e-Health applications. This review provides a systematic overview of recent advancements in metaheuristic algorithms and highlights their applications in e-Health. We selected representative algorithms published between 2019 and 2024, and quantified their influence using an entropy-weighted method based on journal impact factors and citation counts. CThe Harris Hawks Optimizer (HHO) demonstrated the highest early citation impact. The study also examined applications in disease prediction models, clinical decision support, and intelligent health monitoring. Notably, the More >

Himadri Nath Saha¹, Dipanwita Chakraborty Bhattacharya^2,*, Sancharita Dutta³, Arnab Bera³, Srutorshi Basuray⁴, Satyasaran Changdar⁵, Saptarshi Banerjee⁶, Jon Turdiev⁷

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-56, 2026, DOI:10.32604/cmc.2025.070507 - 09 December 2025

Abstract The emergence of Medical Large Language Models has significantly transformed healthcare. Medical Large Language Models (Med-LLMs) serve as transformative tools that enhance clinical practice through applications in decision support, documentation, and diagnostics. This evaluation examines the performance of leading Med-LLMs, including GPT-4Med, Med-PaLM, MEDITRON, PubMedGPT, and MedAlpaca, across diverse medical datasets. It provides graphical comparisons of their effectiveness in distinct healthcare domains. The study introduces a domain-specific categorization system that aligns these models with optimal applications in clinical decision-making, documentation, drug discovery, research, patient interaction, and public health. The paper addresses deployment challenges of Medical-LLMs, More >

Seyong Jin¹, Muhammad Fayaz², L. Minh Dang³, Hyoung-Kyu Song³, Hyeonjoon Moon^2,*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-23, 2026, DOI:10.32604/cmc.2025.070667 - 10 November 2025

Abstract Brain tumors require precise segmentation for diagnosis and treatment plans due to their complex morphology and heterogeneous characteristics. While MRI-based automatic brain tumor segmentation technology reduces the burden on medical staff and provides quantitative information, existing methodologies and recent models still struggle to accurately capture and classify the fine boundaries and diverse morphologies of tumors. In order to address these challenges and maximize the performance of brain tumor segmentation, this research introduces a novel SwinUNETR-based model by integrating a new decoder block, the Hierarchical Channel-wise Attention Decoder (HCAD), into a powerful SwinUNETR encoder. The HCAD… More >

Kwok Tai Chui^1,*, Varsha Arya¹, Brij B. Gupta^2,3,4,*, Miguel Torres-Ruiz⁵, Razaz Waheeb Attar⁶

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-23, 2026, DOI:10.32604/cmc.2025.068842 - 10 November 2025

Abstract Parkinson’s disease (PD) is a debilitating neurological disorder affecting over 10 million people worldwide. PD classification models using voice signals as input are common in the literature. It is believed that using deep learning algorithms further enhances performance; nevertheless, it is challenging due to the nature of small-scale and imbalanced PD datasets. This paper proposed a convolutional neural network-based deep support vector machine (CNN-DSVM) to automate the feature extraction process using CNN and extend the conventional SVM to a DSVM for better classification performance in small-scale PD datasets. A customized kernel function reduces the impact… More >

Guangyu Xu^1,2, Siyuan Xu³, Siyu Lu^4,*, Yuxin Liu¹, Bo Yang¹, Junmin Lyu⁵, Wenfeng Zheng^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4037-4053, 2025, DOI:10.32604/cmes.2025.074901 - 23 December 2025

Abstract Robust stereo disparity estimation plays a critical role in minimally invasive surgery, where dynamic soft tissues, specular reflections, and data scarcity pose major challenges to traditional end-to-end deep learning and deformable model-based methods. In this paper, we propose a novel disparity estimation framework that leverages a pretrained StyleGAN generator to represent the disparity manifold of Minimally Invasive Surgery (MIS) scenes and reformulates the stereo matching task as a latent-space optimization problem. Specifically, given a stereo pair, we search for the optimal latent vector in the intermediate latent space of StyleGAN, such that the photometric reconstruction… More >

Damodharan Palaniappan¹, Tan Kuan Tak², K. Vijayan³, Balajee Maram⁴, Pravin R Kshirsagar⁵, Naim Ahmad^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4107-4127, 2025, DOI:10.32604/cmes.2025.073387 - 23 December 2025

Abstract A phase-aware cross-modal framework is presented that synthesizes UWF_FA from non-invasive UWF_RI for diabetic retinopathy (DR) stratification. A curated cohort of 1198 patients (2915 UWF_RI and 17,854 UWF_FA images) with strict registration quality supports training across three angiographic phases (initial, mid, final). The generator is based on a modified pix2pixHD with an added Gradient Variance Loss to better preserve microvasculature, and is evaluated using MAE, PSNR, SSIM, and MS-SSIM on held-out pairs. Quantitatively, the mid phase achieves the lowest MAE (98.76 ± 42.67), while SSIM remains high across phases. Expert review shows substantial agreement (Cohen’s More >

Asma Batool¹, Fahad Ahmed¹, Naila Sammar Naz¹, Ayman Altameem², Ateeq Ur Rehman^3,4, Khan Muhammad Adnan^5,*, Ahmad Almogren^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4129-4152, 2025, DOI:10.32604/cmes.2025.073149 - 23 December 2025

Abstract Early and accurate cancer diagnosis through medical imaging is crucial for guiding treatment and enhancing patient survival. However, many state-of-the-art deep learning (DL) methods remain opaque and lack clinical interpretability. This paper presents an explainable artificial intelligence (XAI) framework that combines a fine-tuned Visual Geometry Group 16-layer network (VGG16) convolutional neural network with layer-wise relevance propagation (LRP) to deliver high-performance classification and transparent decision support. This approach is evaluated on the publicly available Kaggle kidney cancer imaging dataset, which comprises labeled cancerous and non-cancerous kidney scans. The proposed model achieved 98.75% overall accuracy, with precision, More >