Jarosław Nuszkiewicz^1,*, Joanna Wróblewska¹, Marek Jóźwiak², Marta Pawłowska¹

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.077020 - 22 April 2026

Abstract Melatonin, an endogenous indoleamine primarily synthesized in the pineal gland, has emerged as a promising adjunctive agent within integrative oncology due to its pleiotropic biological actions. Beyond its well-known chronobiological functions, melatonin exerts potent redox-regulatory, anti-inflammatory, oncostatic, and immune-modulating effects that are relevant across multiple stages of carcinogenesis and cancer therapy. Oxidative stress (OS), defined as an imbalance between reactive oxygen and nitrogen species (ROS/RNS) generation and antioxidant defenses, plays a central role in DNA damage, protein adduct formation, and lipid peroxidation, ultimately contributing to mutation accumulation, treatment resistance, and tumor progression. Melatonin modulates these… More >

Marino B. Arnao^1,*, Manuela Giraldo-Acosta¹, Soundouss Kaabi¹, Giuseppe Mannino², Leyla Parra-Almuna³, Josefa Hernández-Ruiz¹, Antonio Cano¹

Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.077309 - 31 March 2026

Abstract Phytomelatonin is a versatile compound with important roles in plants, spanning from promoting germination and plant growth to defending against abiotic and biotic stresses. Its natural origin as biostimulator aligns with sustainable agricultural practices that aim to reduce reliance on synthetic agrochemicals while supporting crop productivity. As research progresses and reveals its full potential across various sectors of agriculture and food production systems, phytomelatonin emerges as a promising candidate for integrated crop management, with the goal of achieving more resilient and sustainable food systems worldwide. More agronomic data will be essential to decide whether the More >

Abdullah Alattar¹, Reem Alshaman¹, Fawaz E. Alanazi¹, Yusuf S. Althobaiti², Ghareb M. Soliman³, Waleed Salman Khubrni¹, Howaida S. Ali⁴, Fawad Ali Shah^5,6,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.074865 - 23 March 2026

Abstract Objectives: Permanent middle cerebral artery occlusion (pMCAO) can lead to hippocampal damage through multiple linked pathways such as reactive oxidative stress (ROS), neuroinflammation mediated by NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), tumour necrosis factor-alpha (TNF-α), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and glutamate excitotoxicity involving N-methyl-D-aspartate receptor subunits 2a and 2b (NR2a/NR2b) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR/GluR1). The hippocampus, which is essential for memory and cognition, is at a substantial risk of ischemic degeneration. The aim of this study was to investigate the neuroprotective potential of melatonin in regulating these… More > Graphic Abstract

Silvia Carloni^1,*, Maria Gemma Nasoni¹, Serafina Perrone², Erik Bargagni¹, Carla Gentile³, Walter Manucha⁴, Russel J. Reiter⁵, Francesca Luchetti^1,*, Walter Balduini^1,*

BIOCELL, Vol.50, No.2, pp. 1-22, 2026, DOI:10.32604/biocell.2025.073776 - 14 February 2026

Abstract Mitochondria are central regulators of cellular energy metabolism, redox balance, and survival, and their dysfunction contributes to neurodegenerative, cardiovascular, and metabolic diseases, as well as aging. Beyond its role as a circadian hormone, melatonin is now recognized as a key modulator of mitochondrial physiology. This review provides an overview of the mechanisms by which melatonin can preserve mitochondrial function through multifaceted mechanisms. Experimental evidence shows that melatonin enhances the activity of electron transport chain (ETC) complexes, stabilizes the mitochondrial membrane potential (Δψ), and prevents cardiolipin (CL) peroxidation, thereby limiting permeability transition pore (mPTP) opening and… More >

George Anderson^*

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.073221 - 14 February 2026

Abstract As natural killer (NK) cells eliminate cancer cells and virus-infected cells, as well as modulate various other medical conditions, including aging-associated conditions such as neurodegenerative disorders, understanding NK cell regulation is of considerable clinical importance. This article reviews the role of circadian processes (melatonin and the cortisol system), aryl hydrocarbon receptor, and vagal nerve in the modulation of NK cell function, highlighting the importance of the endogenous mitochondrial melatonergic pathway in NK cells. As circadian and exogenous melatonin increase NK cell cytotoxicity, the presence of the endogenous melatonergic pathway may be of some importance not… More >

Mayuri Shukla¹, Soraya Boonmag², Parichart Boontem¹, Piyarat Govitrapong^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072557 - 23 January 2026

Abstract Ischemic stroke is one of the major causes of long-term disability and mortality worldwide. It results from an interruption in the cerebral blood flow, triggering a cascade of detrimental events like oxidative stress, mitochondrial dysfunction, neuroinflammation, excitotoxicity, and apoptosis, causing neuronal injury and cellular death. Melatonin, a pleiotropic indoleamine produced by the pineal gland, has multifaceted neuroprotective effects on stroke pathophysiology. Interestingly, the serum melatonin levels are associated with peroxidation and antioxidant status, along with mortality score in patients with severe middle cerebral artery infarction. Melatonin exhibits strong antioxidant, anti-inflammatory, and anti-apoptotic properties and preserves More >

Luis Felipe HernáNdez-Ayala¹, Russel J. Reiter², Annia Galano^1,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.071635 - 23 January 2026

Abstract Objectives: Oxidative stress (OS) plays a pivotal role in chronic and neurodegenerative diseases, which has sparked interest in molecules that modulate redox-regulating enzymes. Melatonin and its metabolites exhibit antioxidant properties; however, their molecular mechanisms of enzymatic and transcriptional modulation remain unclear. This study aimed to investigate, through an exploratory in silico approach, the interactions of melatonin and related compounds with OS-related enzymes to generate hypotheses about their role in cellular redox control. Methods: A rational selection of antioxidant, pro-oxidant, and transcriptional targets was performed. Ligands were optimized at the DFT level (M05-2X/6-311+G(d,p)) and docked to OS… More >

JOSé A. BOGA^1,2, ANA COTO-MONTES^2,3,*, RUSSEL J. REITER⁴

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068245 - 23 January 2026

Abstract Aerobic glycolysis, also known as the Warburg effect, and the accumulation of lactate that it causes, are increasingly recognized outside the field of oncology as triggers of chronic non-neoplastic disorders. This review integrates preclinical and clinical evidence to evaluate the ability of melatonin to reverse Warburg-effect-like metabolic reprogramming. Literature on neurodegeneration, age-related sarcopenia, type 2 diabetes, chronic kidney disease, heart failure and pulmonary arterial hypertension (PAH) has been reviewed and synthesised. In all of these conditions, hypoxia-inducible factor 1α (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) inhibit the pyruvate dehydrogenase complex. This diverts pyruvate away… More >

Tai Liu^1,#, Huichun Xu^1,#, Sikandar Amanullah^2,*, Ye Che¹, Ling Zhang¹, Zeyu Jiang¹, Weiyi Bi¹, Lei Zhu¹, Di Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 4117-4137, 2025, DOI:10.32604/phyton.2025.074131 - 29 December 2025

Abstract Heavy metal accumulation in agricultural soil is primarily driven by pesticides, polluted water, and industrial gas emissions, which pose threats to sustainable crop production. Chromium (Cr) stress has an adverse impact on plant development and metabolism, but approaches to reduce its toxicity and enhance plant resistance remain limited. Melatonin is a potent antioxidant involved in regulating various morpho-physiological functions of plants under different abiotic stresses. In this study, we investigated the impact of exogenous melatonin to mitigate the negative effects of potassium dichromate (PD) stress in melon plants and analyzed genetic modulation of morphological, physiological,… More >

Totan Kumar Ghosh¹, Md. Roushonuzzaman Rakib¹, Munna¹, S. M. Zubair AL-Meraj¹, Md. Moshiul Islam², Anika Nazran¹, Mohammad Golam Mostofa^3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3925-3943, 2025, DOI:10.32604/phyton.2025.073382 - 29 December 2025

Abstract The productivity of common bean (Phaseolus vulgaris L.), an economically important legume, is severely hindered by drought stress. While melatonin (Mel) and methyl jasmonate (MeJA) are known to alleviate abiotic stresses, their combined effects in mitigating drought-induced oxidative stress are unknown. Here, we examined the synergistic effects of Mel and MeJA in alleviating drought-associated oxidative damage in common bean. Compared with well-watered controls, drought stress caused a significant decline in plant biomass, photosynthetic pigments, and photosystem II efficiency (F_v/F_m). Drought also significantly increased hydrogen peroxide (H₂O₂) accumulation, which likely contributed to membrane lipid peroxidation, as indicated by… More >