Manisha Choudhari¹, Shantanu Damle², Rajat Vashist¹, Ranendra Narayan Saha³, Sunil Kumar Dubey⁴, Gautam Singhvi^1,*

Journal of Polymer Materials, Vol.42, No.4, pp. 1199-1229, 2025, DOI:10.32604/jpm.2025.072987 - 26 December 2025

Abstract Abiraterone acetate (ABTA) was approved by the USFDA in 2011 for treating metastatic castration-resistant prostate cancer (mCRPC). ABTA exhibits poor aqueous solubility, inadequate dissolution, low oral bioavailability (<10%), and significant positive food effects. To overcome these limitations, in the present work, ABTA solid dispersions (SDs) were developed by using hot melt extrusion technology (HME) with various grades of hydroxypropyl methylcellulose HME (HPMC HME 15LV and 100LV) at different extrusion temperatures. HPMC HME demonstrated the ability to prevent drug precipitation for up to 120 min compared to the free drug (10 min), sustaining the supersaturation state… More > Graphic Abstract

Hui Zheng^1,2, Xiaohan Chen², Li Li², Dawei Qi¹, Jiale Wang¹, Jiaying Lou^1,*, Wenjun Wang^1,*

Journal of Renewable Materials, Vol.11, No.10, pp. 3693-3709, 2023, DOI:10.32604/jrm.2023.027748 - 10 August 2023

Abstract The issue of plastic pollution has attracted widespread social attention. Gelatin is valued as a degradable bio-based material, especially as an edible active packaging material. However, the commonly used solution-casting filmforming technology limits the mass production of gelatin films. In order to improve the production efficiency and enhance the commercial value of gelatin films, in this study, fish gelatin (FG) particles were successfully blended with essential oils (EOs) to prepare active films by melt extrusion technique, a common method for commercial plastics, and applied to bread preservation. FG and EOs showed good compatibility with each… More > Graphic Abstract

Norma M. P. Machado¹, Gustavo C. Melo¹, Matheus F. Camargo¹, Giulianna G. Feijó¹, Bruna M. S. Putton², Clarice Steffens², Rogerio L. Cansian², Luiz A. Pessan¹, Francys K. V. Moreira^1,*

Journal of Renewable Materials, Vol.9, No.2, pp. 337-349, 2021, DOI:10.32604/jrm.2021.011081 - 15 December 2020

Abstract Food packaging materials compounded with antimicrobial additives can substantially diminish the incidence of foodborne diseases. Here, poly(L-lactic acid) (PLA) films containing sodium metabisulfite (NaM) were produced by melt extrusion as an attempt to develop a new biodegradable material with antimicrobial properties for packaging. Life cycle assessment (LCA) simulations revealed that the environmental footprints of the PLA film did not change upon NaM addition, and that NaM is more eco-friendly than silver nanoparticles. The PLA/NaM films with NaM content varying from 0.5 to 5.0 wt.% were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and… More >