YUNAN MAO1,#, JINZE SHEN1,#, LI FANG2, FENG ZHU1,*, SHIWEI DUAN1,*
Oncology Research, Vol.31, No.1, pp. 1-12, 2023, DOI:10.32604/or.2022.027359
Abstract miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to
be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation,
migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR,
RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression
of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC,
PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and… More >
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