Zhen Li*1,
Xin Li*1,
Xiao Du†, Henghui Zhang†, Zhengyang Wu*, Kewei Ren*, Xinwei Han*
Oncology Research, Vol.27, No.6, pp. 663-672, 2019, DOI:10.3727/096504018X15420741307616
Abstract Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary carcinoma. The long noncoding
RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported to contribute to the progression
of multiple cancers. Nonetheless, the functions and hidden mechanism of SNHG1 remain unclear in CCA. In
this study, the SNHG1 levels were boosted in CCA cell lines, and knockdown of SNHG1 repressed CCA cell
proliferation and invasion in vitro. The data also demonstrated that miR-140 could act as a target of SNHG1 in
CCA and inhibited CCA cell proliferation and invasion, whereas the inhibition effects were relieved by overexpression of… More >
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